Paper · 62753

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

Kellems RE and 2 others. J Biol Chem, 1976. Cited by 87 papers, by iCite.

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ConductScience Library. Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. Papers, record 62753. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/62753

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.; PubMed
Journal: J Biol Chem; PubMed
Year: 1976; PubMed
Publication types: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/62753/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 87; iCite
Relative citation ratio, by iCite: 1.93; iCite
Revised in PubMed: 2021-02-10; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kellems RE	R E
2	Alt FW	F W
3	Schimke RT	R T

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Methotrexate	Major topic
Protein Biosynthesis	Major topic
RNA, Messenger	Major topic
Sarcoma 180	Major topic
Tetrahydrofolate Dehydrogenase	Major topic
Animals
Cell Line
Drug Resistance
Kinetics
Nucleic Acid Denaturation
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by21

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 87 citations.

PMID	Title	Journal	Year	In Papers	Source
7,217,199	Regulation of the synthesis of lactate dehydrogenase-X during spermatogenesis in the mouse.	J Cell Biol	1981	https://conductscience.org/library/papers/7217199	PubMed
7,110,138	Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.	Mol Cell Biol	1982	https://conductscience.org/library/papers/7110138	PubMed
7,061,595	Amplified dihydrofolate reductase genes are located in chromosome regions containing DNA that replicates during the first half of S-phase.	J Cell Biol	1982	https://conductscience.org/library/papers/7061595	PubMed
6,943,571	On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6943571	PubMed
6,933,549	Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6933549	PubMed
6,736,126	Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.	J Cell Biol	1984	https://conductscience.org/library/papers/6736126	PubMed
6,646,125	Delayed processing of dihydrofolate reductase heterogeneous nuclear RNA in amino acid-starved mouse fibroblasts.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6646125	PubMed
6,411,680	Identification of the type I trimethoprim-resistant dihydrofolate reductase specified by the Escherichia coli R-plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases.	J Bacteriol	1983	https://conductscience.org/library/papers/6411680	PubMed
6,287,233	Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.	Mol Cell Biol	1982	https://conductscience.org/library/papers/6287233	PubMed
6,180,296	Control of dihydrofolate reductase messenger ribonucleic acid production.	Mol Cell Biol	1981	https://conductscience.org/library/papers/6180296	PubMed

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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