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Paper · 6943571

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

Varshavsky A. Proc Natl Acad Sci U S A, 1981. Cited by 109 papers, by iCite.

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ConductScience Library. On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages. Papers, record 6943571. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6943571

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1981
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
109
iCite
Relative citation ratio, by iCite
2.32
iCite
Revised in PubMed
2019-05-01
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Varshavsky AA

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene AmplificationMajor topic
NeoplasmsMajor topic
RepliconMajor topic
Animals
Cell Cycle
Cell Line
Cocarcinogenesis
Phenotype
Virus Replication

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References58

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,842,257Proceedings: Tumor angiogenesis factor.Cancer Res1974https://conductscience.org/library/papers/4842257PubMed
2493,994Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.Science1979https://conductscience.org/library/papers/493994PubMed
3308,698Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.Science1978https://conductscience.org/library/papers/308698PubMed
4947,547Elevated dihydrofolate reductase messenger RNA levels in methotrexate-resistant BHK cells.Cell1976https://conductscience.org/library/papers/947547PubMed
5620,412Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.Cancer Res1978https://conductscience.org/library/papers/620412PubMed
6381,311Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.J Biol Chem1979https://conductscience.org/library/papers/381311PubMed
7649,427Have double minutes functioning centromeres?Hereditas1978https://conductscience.org/library/papers/649427PubMed
81,094,915DNA replication.Annu Rev Biochem1975https://conductscience.org/library/papers/1094915PubMed
9269,404Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/269404PubMed
10286,311Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/286311PubMed

1 to 10 of 58

See all 58 references

Cited by37

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 109 citations.

PMIDTitleJournalYearIn PapersSource
34,112,178Extrachromosomal circular DNA: a new potential role in cancer progression.J Transl Med2021https://conductscience.org/library/papers/34112178PubMed
33,294,253The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution.Am J Cancer Res2020https://conductscience.org/library/papers/33294253PubMed
32,651,540Genome instability in multiple myeloma.Leukemia2020https://conductscience.org/library/papers/32651540PubMed
24,306,989Extrachromosomal DNA of pea-root (Pisum sativum) has repeated sequences and ribosomal genes.Plant Mol Biol1985https://conductscience.org/library/papers/24306989PubMed
23,119,227Unbalanced replication as a major source of genetic instability in cancer cells.Am J Blood Res2012https://conductscience.org/library/papers/23119227PubMed
21,455,918Identification of drug targets in vitro and in living cells by soluble-nanopolymer-based proteomics.Angew Chem Int Ed Engl2011https://conductscience.org/library/papers/21455918PubMed
20,736,315Specific replication origins promote DNA amplification in fission yeast.J Cell Sci2010https://conductscience.org/library/papers/20736315PubMed
8,559,653Preference of the recombination sites involved in the formation of extrachromosomal copies of the human alphoid Sau3A repeat family.Nucleic Acids Res1995https://conductscience.org/library/papers/8559653PubMed
8,392,627Amplification mediated by polyomavirus large T antigen defective in replication.J Virol1993https://conductscience.org/library/papers/8392627PubMed
8,055,713DNA amplification: new insights into its mechanism.Chromosoma1994https://conductscience.org/library/papers/8055713PubMed

1 to 10 of 37

See all 37 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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