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Paper6180331

Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to substance P release.

Chahl LA. Naunyn Schmiedebergs Arch Pharmacol, 1982. Cited by 66 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to substance P release. Papers, record 6180331. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6180331

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to substance P release.
PubMed
Journal
Naunyn Schmiedebergs Arch Pharmacol
PubMed
Year
1982
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
66
iCite
Relative citation ratio, by iCite
3.17
iCite
Revised in PubMed
2019-07-25
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chahl LAL A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CapsaicinMajor topic
Fatty Acids, UnsaturatedMajor topic
IleumMajor topic
Muscle ContractionMajor topic
Substance PMajor topic
Acetylcholine
Animals
Atropine
Female
Guinea Pigs
In Vitro Techniques
Male
Physostigmine

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,189,941Influence of substance P on the response of guinea pig ileum to transmural nerve stimulation.Acta Physiol Scand1975https://conductscience.org/library/papers/1189941PubMed
2723,972New type of nerve-mediated cholinergic contractions of the guinea-pig small intestine and its selective blockade by capsaicin.Naunyn Schmiedebergs Arch Pharmacol1978https://conductscience.org/library/papers/723972PubMed
36,163,995Substance P immunoreactive neurons following neonatal administration of capsaicin.Naunyn Schmiedebergs Arch Pharmacol1981https://conductscience.org/library/papers/6163995PubMed
4502,756Substance P release from spinal cord slices by capsaicin.Life Sci1979https://conductscience.org/library/papers/502756PubMed
56,154,904Distribution of enteric neurons showing immunoreactivity for substance P in the guinea-pig ileum.Neuroscience1980https://conductscience.org/library/papers/6154904PubMed
66,157,098Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.Nature1980https://conductscience.org/library/papers/6157098PubMed
7912,944A pharmacological investigation of synthetic substance P on the isolated guinea-pig ileum.Clin Exp Pharmacol Physiol1977https://conductscience.org/library/papers/912944PubMed
86,164,015Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin.Neuroscience1981https://conductscience.org/library/papers/6164015PubMed
96,162,128Acetylcholinesterase hydrolyzes substance P.Neuroscience1980https://conductscience.org/library/papers/6162128PubMed
106,165,593In vitro release of substance P from spinal cord slices by capsaicin congeners.Eur J Pharmacol1981https://conductscience.org/library/papers/6165593PubMed
116,159,532Evidence that substance P is a neurotransmitter in the myenteric plexus.Nature1980https://conductscience.org/library/papers/6159532PubMed
126,189,007Neurally mediated contraction of ileal longitudinal muscle by substance P.Neurosci Lett1980https://conductscience.org/library/papers/6189007PubMed
136,164,014Projections of substance P-containing neurons within the guinea-pig small intestine.Neuroscience1981https://conductscience.org/library/papers/6164014PubMed
1431,571The site of action of capsaicin on the guinea-pig isolated ileum.Naunyn Schmiedebergs Arch Pharmacol1978https://conductscience.org/library/papers/31571PubMed
156,171,138Chemical design of antagonists of substance P.Acta Physiol Scand1981https://conductscience.org/library/papers/6171138PubMed
166,157,545Substance P-induced autodesensitization inhibits atropine-resistant, neurotensin-stimulated contractions in guinea-pig ileum.Eur J Pharmacol1980https://conductscience.org/library/papers/6157545PubMed
17466,404Capsaicin-evoked release of substance P from primary sensory neurons.Brain Res1979https://conductscience.org/library/papers/466404PubMed
186,153,986Distribution of substance P in the rat gastrointestinal tract--lack of effect of capsaicin pretreatment.Eur J Pharmacol1980https://conductscience.org/library/papers/6153986PubMed

Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMIDTitleJournalYearIn PapersSource
8,750,923The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide.Naunyn Schmiedebergs Arch Pharmacol1995https://conductscience.org/library/papers/8750923PubMed
6,482,984Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog.Naunyn Schmiedebergs Arch Pharmacol1984https://conductscience.org/library/papers/6482984PubMed
6,203,588Desensitization of the guinea-pig urinary bladder by the enantiomers of adenylyl 5'-(beta, gamma-methylene)-diphosphonate and by substance P.Br J Pharmacol1984https://conductscience.org/library/papers/6203588PubMed
6,085,949Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.Br J Pharmacol1983https://conductscience.org/library/papers/6085949PubMed
3,580,706Evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestine.Br J Pharmacol1987https://conductscience.org/library/papers/3580706PubMed
3,491,329
Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons.
Naunyn Schmiedebergs Arch Pharmacol1986https://conductscience.org/library/papers/3491329PubMed
2,582,276Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms.Naunyn Schmiedebergs Arch Pharmacol1985https://conductscience.org/library/papers/2582276PubMed
2,468,417Distribution of substance P in the enteric plexuses of the small intestine of the platypus, Ornithorhynchus anatinus.Cell Tissue Res1989https://conductscience.org/library/papers/2468417PubMed
2,445,407Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.Br J Pharmacol1987https://conductscience.org/library/papers/2445407PubMed
2,442,628Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum.Naunyn Schmiedebergs Arch Pharmacol1987https://conductscience.org/library/papers/2442628PubMed
2,431,327A pharmacological and immunohistochemical study of the splanchnic innervation of ileal longitudinal muscle in the toad Bufo marinus.Naunyn Schmiedebergs Arch Pharmacol1986https://conductscience.org/library/papers/2431327PubMed
2,431,326Antagonist discrimination between subtypes of tachykinin receptors in the guinea-pig ileum.Naunyn Schmiedebergs Arch Pharmacol1986https://conductscience.org/library/papers/2431326PubMed
2,430,191Withdrawal responses of guinea-pig isolated ileum following brief exposure to opiates and opioid peptides.Naunyn Schmiedebergs Arch Pharmacol1986https://conductscience.org/library/papers/2430191PubMed
2,426,605Effects of capsaicin on vascular smooth muscle.Naunyn Schmiedebergs Arch Pharmacol1986https://conductscience.org/library/papers/2426605PubMed
2,426,161Occurrence and distribution of a newly discovered peptide, galanin, in the mammalian enteric nervous system.Gut1986https://conductscience.org/library/papers/2426161PubMed
1,691,941Dual effects of capsaicin on responses of the rabbit ear artery to field stimulation.Br J Pharmacol1990https://conductscience.org/library/papers/1691941PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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