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Paper · 6334697

Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1.

Wewers MD and 4 others. J Clin Invest, 1984. Cited by 189 papers, by iCite.

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ConductScience Library. Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1. Papers, record 6334697. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6334697

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1.
PubMed
Journal
J Clin Invest
PubMed
Year
1984
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
189
iCite
Relative citation ratio, by iCite
4.98
iCite
Revised in PubMed
2018-11-13
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wewers MDM D
2Rennard SIS I
3Hance AJA J
4Bitterman PBP B
5Crystal RGR G

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Interleukin-1Major topic
MacrophagesMajor topic
Chromatography, DEAE-Cellulose
Chromatography, Gel
Fibronectins
Humans
Isoelectric Focusing
Lipopolysaccharides
Lung
Methionine
Monocytes
Phagocytosis
Therapeutic Irrigation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,028,491Release of an endogenous pyrogen in vitro from rabbit mononuclear cells.J Exp Med1967https://conductscience.org/library/papers/6028491PubMed
26,614,646Human alveolar macrophage support of lymphocyte responses to mitogens and antigens. Analysis and comparison with autologous peripheral-blood-derived monocytes and macrophages.Am Rev Respir Dis1983https://conductscience.org/library/papers/6614646PubMed
35,033,417Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.J Exp Med1972https://conductscience.org/library/papers/5033417PubMed
44,357,270Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes.Blood1973https://conductscience.org/library/papers/4357270PubMed
54,850,204A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.Eur J Biochem1974https://conductscience.org/library/papers/4850204PubMed
6137,265Bidirectional amplification of macrophage-lymphocyte interactions: enhanced lymphocyte activation factor production by activated adherent mouse peritoneal cells.J Immunol1977https://conductscience.org/library/papers/137265PubMed
7321,778Studies of lymphocyte activating factor from alveolar macrophages.J Reticuloendothel Soc1977https://conductscience.org/library/papers/321778PubMed
8300,751Purification and properties of human lymphocyte activating factor (LAF).J Immunol1977https://conductscience.org/library/papers/300751PubMed
9659,595Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.J Clin Invest1978https://conductscience.org/library/papers/659595PubMed
10307,016Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS.J Immunol1978https://conductscience.org/library/papers/307016PubMed

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Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 189 citations.

PMIDTitleJournalYearIn PapersSource
38,619,302Flagellin-modulated inflammasome pathways characterize the human alveolar macrophage response to Burkholderia pseudomallei, a lung-tropic pathogen.Infect Immun2024https://conductscience.org/library/papers/38619302PubMed
32,726,944Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis.Viruses2020https://conductscience.org/library/papers/32726944PubMed
25,629,767
House Dust Mite Allergens and the Induction of Monocyte Interleukin 1β Production That Triggers an IκBζ-Dependent Granulocyte Macrophage Colony-Stimulating Factor Release from Human Lung Epithelial Cells.
Am J Respir Cell Mol Biol2015https://conductscience.org/library/papers/25629767PubMed
25,267,839Bordetella parapertussis survives inside human macrophages in lipid raft-enriched phagosomes.Infect Immun2014https://conductscience.org/library/papers/25267839PubMed
24,666,941Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell.Crit Care2014https://conductscience.org/library/papers/24666941PubMed
23,864,058Macrophages in tuberculosis: friend or foe.Semin Immunopathol2013https://conductscience.org/library/papers/23864058PubMed
22,915,818Seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory T cell phenotypes.J Virol2012https://conductscience.org/library/papers/22915818PubMed
20,084,270The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.PLoS One2010https://conductscience.org/library/papers/20084270PubMed
19,494,323Pyrin critical to macrophage IL-1beta response to Francisella challenge.J Immunol2009https://conductscience.org/library/papers/19494323PubMed
19,214,778P2X(7) receptor and macrophage function.Purinergic Signal2009https://conductscience.org/library/papers/19214778PubMed

1 to 10 of 46

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
IL1A3,552PubTator's text mininghttps://conductscience.org/library/genes/3552

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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