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Paper65452

Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years.

Gonsette RE and 2 others. J Neurol, 1977. Cited by 100 papers, by iCite.

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ConductScience Library. Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years. Papers, record 65452. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/65452

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years.
PubMed
Journal
J Neurol
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
100
iCite
Relative citation ratio, by iCite
3.19
iCite
Revised in PubMed
2019-08-27
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gonsette RER E
2Demonty LL
3Delmotte PP

Source PubMed

Topics5

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CyclophosphamideMajor topic
Multiple SclerosisMajor topic
Adult
Follow-Up Studies
Humans

Source PubMed

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
172,790Failure of basic protein therapy for multiple sclerosis.J Neurol1977https://conductscience.org/library/papers/72790PubMed
24,119,511Multiple sclerosis unaffected by azathioprine in pilot study.Arch Neurol1973https://conductscience.org/library/papers/4119511PubMed
35,035,906Effect of 'maximum immune suppression' with thoracic duct drainage, ALG, azathioprine and cortisone in some neurological disorders.Proc R Soc Med1972https://conductscience.org/library/papers/5035906PubMed
41,237,376Intensive immunosuppression in patients with disseminated sclerosis. I. Clinical response.Clin Exp Immunol1975https://conductscience.org/library/papers/1237376PubMed
55,783,817A preliminary evaluation of azathioprine (Imuran) in the treatment of multiple sclerosis.Henry Ford Hosp Med J1969https://conductscience.org/library/papers/5783817PubMed
64,563,026Immune status of patients with multiple sclerosis. Analysis of primary and established immune responses in 24 patients.Neurology1972https://conductscience.org/library/papers/4563026PubMed
76,025,851[Immunodepressive therapy in neurology].Presse Med (1893)1967https://conductscience.org/library/papers/6025851PubMed
84,358,999Evaluation of antithymocyte globulin in acute relapses of multiple sclerosis.Neurology1974https://conductscience.org/library/papers/4358999PubMed
95,710,171[Immunosuppressive agents in multiple sclerosis. Preliminary trials with Proresid].Wien Med Wochenschr1968https://conductscience.org/library/papers/5710171PubMed
104,367,744[Critic study of multiple sclerosis treatment by chlorambucil and intraspinal corticotherapy. Apropos of 100 cases followed up from 2 to 9 years].Rev Neurol (Paris)1973https://conductscience.org/library/papers/4367744PubMed
114,180,869Cyclophosphamide in multiple sclerosis.Lancet1969https://conductscience.org/library/papers/4180869PubMed
124,541,183Failure of antilymphocytic globulin therapy in chronic progressive multiple sclerosis.Neurology1973https://conductscience.org/library/papers/4541183PubMed
134,139,403Intensive immunosuppression in the treatment of multiple sclerosis.Lancet1974https://conductscience.org/library/papers/4139403PubMed
141,097,604Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies.J Neurol Neurosurg Psychiatry1975https://conductscience.org/library/papers/1097604PubMed
155,906,182[Multiple sclerosis and the autoimmunization process. Treatment by antimitotics].Lyon Med1966https://conductscience.org/library/papers/5906182PubMed
16171,349An immunopathologic component in experimental togavirus encephalitis.J Neuropathol Exp Neurol1975https://conductscience.org/library/papers/171349PubMed
17765,862[Treatment of multiple sclerosis using immunosuppression. Critical discussion of results].Ned Tijdschr Geneeskd1976https://conductscience.org/library/papers/765862PubMed
185,516,334[Treatment of multiple sclerosis with intraspinal antilymphocyte serum: theoretical bases; opportunities for utilization].Rev Neurol (Paris)1970https://conductscience.org/library/papers/5516334PubMed
194,631,348Therapeutic trial of immunosuppressive agents in multiple sclerosis.Neurology1972https://conductscience.org/library/papers/4631348PubMed
204,314,087Multiple sclerosis: pilot therapeutic trial of immunosuppressants.Schweiz Arch Neurol Neurochir Psychiatr1969https://conductscience.org/library/papers/4314087PubMed

See all 33 references

Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 100 citations.

PMIDTitleJournalYearIn PapersSource
34,940,954Multiple Sclerosis in Children: Differential Diagnosis, Prognosis, and Disease-Modifying Treatment.CNS Drugs2022https://conductscience.org/library/papers/34940954PubMed
34,079,516Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities.Front Neurol2021https://conductscience.org/library/papers/34079516PubMed
27,928,949From Leflunomide to Teriflunomide: Drug Development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis.Curr Neuropharmacol2017https://conductscience.org/library/papers/27928949PubMed
23,271,506Role of immunosuppressive therapy for the treatment of multiple sclerosis.Neurotherapeutics2013https://conductscience.org/library/papers/23271506PubMed
21,865,410Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance.Mult Scler2012https://conductscience.org/library/papers/21865410PubMed
21,547,093Lights and shadows of cyclophosphamide in the treatment of multiple sclerosis.Autoimmune Dis2011https://conductscience.org/library/papers/21547093PubMed
19,774,497Immunomodulatory therapies in neurologic critical care.Neurocrit Care2010https://conductscience.org/library/papers/19774497PubMed
19,439,723Cyclophosphamide therapy in pediatric multiple sclerosis.Neurology2009https://conductscience.org/library/papers/19439723PubMed
17,253,481Cyclophosphamide for multiple sclerosis.Cochrane Database Syst Rev2007https://conductscience.org/library/papers/17253481PubMed
15,940,386The combination of cyclophosphamide plus interferon beta as rescue therapy could be used to treat relapsing-remitting multiple sclerosis patients-- twenty-four months follow-up.J Neurol2005https://conductscience.org/library/papers/15940386PubMed
15,645,351Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon beta.J Neurol2004https://conductscience.org/library/papers/15645351PubMed
6,896,866Intrathecal methylprednisolone acetate in multiple sclerosis treatment: effect on the blood-CSF barrier and on the intrathecal IgG production.Ital J Neurol Sci1982https://conductscience.org/library/papers/6896866PubMed
6,196,462Immunological treatment of multiple sclerosis.J Neurol1983https://conductscience.org/library/papers/6196462PubMed
6,164,763Short-term intensive cyclophosphamide treatment in multiple sclerosis. A retrospective controlled study.J Neurol1981https://conductscience.org/library/papers/6164763PubMed
6,157,007Azathioprine in multiple sclerosis--a 3 year controlled study of its effectiveness.J Neurol1980https://conductscience.org/library/papers/6157007PubMed
3,571,433Increased spontaneous immunoglobulin secretion associated with cyclophosphamide-induced immune suppression.J Clin Immunol1987https://conductscience.org/library/papers/3571433PubMed
3,429,217Short-term intensive cyclophosphamide treatment in progressive multiple sclerosis.Ital J Neurol Sci1987https://conductscience.org/library/papers/3429217PubMed
3,171,613The need for a new strategy for the treatment of multiple sclerosis.J Neurol1988https://conductscience.org/library/papers/3171613PubMed
2,982,564Multiple sclerosis. Current concepts in management.Drugs1985https://conductscience.org/library/papers/2982564PubMed
2,850,189T-lymphocyte subpopulations in multiple sclerosis--do they help to judge immunosuppressive therapy?Eur Arch Psychiatry Neurol Sci1988https://conductscience.org/library/papers/2850189PubMed

See all 25 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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