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Paper72790

Failure of basic protein therapy for multiple sclerosis.

Gonsette RE and 2 others. J Neurol, 1977. Cited by 47 papers, by iCite.

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ConductScience Library. Failure of basic protein therapy for multiple sclerosis. Papers, record 72790. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/72790

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Failure of basic protein therapy for multiple sclerosis.
PubMed
Journal
J Neurol
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
47
iCite
Relative citation ratio, by iCite
1.06
iCite
Revised in PubMed
2019-08-27
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gonsette RER E
2Delmotte PP
3Demonty LL

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Multiple SclerosisMajor topic
Nerve Tissue ProteinsMajor topic
Adult
Desensitization, Immunologic
Female
Follow-Up Studies
Humans
Male
Middle Aged

Source PubMed

References14

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,035,906Effect of 'maximum immune suppression' with thoracic duct drainage, ALG, azathioprine and cortisone in some neurological disorders.Proc R Soc Med1972https://conductscience.org/library/papers/5035906PubMed
21,237,376Intensive immunosuppression in patients with disseminated sclerosis. I. Clinical response.Clin Exp Immunol1975https://conductscience.org/library/papers/1237376PubMed
34,125,887Prevention of experimental allergic encephalomyelitis by nonencephalitogenic basic peptides.Arch Biochem Biophys1973https://conductscience.org/library/papers/4125887PubMed
44,623,901Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.Prep Biochem1972https://conductscience.org/library/papers/4623901PubMed
54,139,403Intensive immunosuppression in the treatment of multiple sclerosis.Lancet1974https://conductscience.org/library/papers/4139403PubMed
64,123,119Myelin basic protein administration in multiple sclerosis.Arch Neurol1973https://conductscience.org/library/papers/4123119PubMed
772,138Biochemical findings in multiple sclerosis. V. Transformation of lymphocytes from patients with multiple sclerosis by human basic protein.J Neurol1977https://conductscience.org/library/papers/72138PubMed
84,728,676Antigen-induced inhibition of experimental allergic encephalomyelitis. II. Studies in guinea pigs with the small rat myelin basic protein.J Immunol1973https://conductscience.org/library/papers/4728676PubMed
95,361,567Cyclophosphamide inhibition of experimental allergic encephalomyelitis and cellular transfer of the disease in Lewis rats.J Immunol1969https://conductscience.org/library/papers/5361567PubMed
1065,452Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years.J Neurol1977https://conductscience.org/library/papers/65452PubMed
111,157,430Treatment of the chronic progressive form of multiple sclerosis with a combination of cyclophosphamide and prednisone.Clin Neurol Neurosurg1975https://conductscience.org/library/papers/1157430PubMed
124,119,624Protection against experimental allergic encephalomyelitis.Nature1972https://conductscience.org/library/papers/4119624PubMed
134,130,537Immunopathological comparisons between experimental autoimmune encephalomyelitis and multiple sclerosis.Clin Exp Immunol1973https://conductscience.org/library/papers/4130537PubMed
144,608,406Critique of experimental trials of therapy in multiple sclerosis.Neurology1974https://conductscience.org/library/papers/4608406PubMed

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 47 citations.

PMIDTitleJournalYearIn PapersSource
37,283,612Recombinant MBP-pσ1 expressed in soybean seeds delays onset and reduces developing disease in an animal model of multiple sclerosis.Plant Biotechnol (Tokyo)2022https://conductscience.org/library/papers/37283612PubMed
35,919,740Advancement of antigen-specific immunotherapy: knowledge transfer between allergy and autoimmunity.Immunother Adv2021https://conductscience.org/library/papers/35919740PubMed
22,140,475'Multi-epitope-targeted' immune-specific therapy for a multiple sclerosis-like disease via engineered multi-epitope protein is superior to peptides.PLoS One2011https://conductscience.org/library/papers/22140475PubMed
20,850,958Antigen-specific immunotherapy of autoimmune and allergic diseases.Curr Opin Immunol2010https://conductscience.org/library/papers/20850958PubMed
18,000,062Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/18000062PubMed
17,213,317Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/17213317PubMed
6,194,137Myelin basic protein and multiple sclerosis.Ital J Neurol Sci1983https://conductscience.org/library/papers/6194137PubMed
6,083,467Treatment of experimental allergic encephalomyelitis with myelin basic protein: which route is best?Neurochem Res1984https://conductscience.org/library/papers/6083467PubMed
2,982,564Multiple sclerosis. Current concepts in management.Drugs1985https://conductscience.org/library/papers/2982564PubMed
2,469,764Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.J Exp Med1989https://conductscience.org/library/papers/2469764PubMed
676,686Chronic relapsing experimental allergic encephalomyelitis: CNS plaque development in unsuppressed and suppressed animals.Acta Neuropathol1978https://conductscience.org/library/papers/676686PubMed
88,679Suppression and reversal of allergic encephalomyelitis in rhesus monkeys with basic protein and peptides.Neurochem Res1979https://conductscience.org/library/papers/88679PubMed
65,452Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years.J Neurol1977https://conductscience.org/library/papers/65452PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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