Paper · 68474

Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.

Thomas DW and 1 other. Proc Natl Acad Sci U S A, 1977. Cited by 90 papers, by iCite.

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ConductScience Library. Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages. Papers, record 68474. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/68474

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/68474/; PubMed
DOI: https://doi.org/10.1073/pnas.74.5.2104; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC431083/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 90; iCite
Relative citation ratio, by iCite: 1.78; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Thomas DW	D W
2	Shevach EM	E M

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens	Major topic
Immunity, Cellular	Major topic
Isoantigens	Major topic
Macrophages	Major topic
T-Lymphocytes	Major topic
Animals
Binding Sites
Bromodeoxyuridine
Epitopes
Guinea Pigs
Haptens
Histocompatibility Antigens
Immunologic Memory
Light
Lymphocyte Culture Test, Mixed
Trinitrobenzenes

Source PubMed

Grants0

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Trials0

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Comments and corrections0

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References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,078,737	The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.	Transplant Rev	1975	https://conductscience.org/library/papers/1078737	PubMed
2	1,079,850	Suppression of in vitro antibody synthesis by immunoglobulin-binding factor.	J Exp Med	1975	https://conductscience.org/library/papers/1079850	PubMed
3	1,082,923	Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.	J Exp Med	1976	https://conductscience.org/library/papers/1082923	PubMed
4	1,083,875	The function of macrophages in antigen recognition by guinea pig T lymphocytes. III. Genetic analysis of the antigens mediating macrophage-T lymphocyte interaction.	J Immunol	1976	https://conductscience.org/library/papers/1083875	PubMed
5	1,084,997	Role of major histocompatibility complex gene products in delayed-type hypersensitivity.	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/1084997	PubMed
6	4,126,770	Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.	J Exp Med	1973	https://conductscience.org/library/papers/4126770	PubMed
7	4,139,235	Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.	J Exp Med	1974	https://conductscience.org/library/papers/4139235	PubMed
8	47,900	Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.	J Exp Med	1975	https://conductscience.org/library/papers/47900	PubMed
9	47,901	H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.	J Exp Med	1975	https://conductscience.org/library/papers/47901	PubMed
10	5,112,203	The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.	J Exp Med	1971	https://conductscience.org/library/papers/5112203	PubMed

1 to 10 of 16

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Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 90 citations.

PMID	Title	Journal	Year	In Papers	Source
14,504,410	Negative selection imparts peptide specificity to the mature T cell repertoire.	Proc Natl Acad Sci U S A	2003	https://conductscience.org/library/papers/14504410	PubMed
8,265,615	Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.	Proc Natl Acad Sci U S A	1993	https://conductscience.org/library/papers/8265615	PubMed
7,911,822	Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.	J Exp Med	1994	https://conductscience.org/library/papers/7911822	PubMed
7,035,869	Tuftsin, Thr-Lys-Pro-Arg. Anatomy of an immunologically active peptide.	Mol Cell Biochem	1981	https://conductscience.org/library/papers/7035869	PubMed
6,980,965	Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.	J Exp Med	1982	https://conductscience.org/library/papers/6980965	PubMed
6,980,258	Restriction molecules involved in the interaction of T cells with allogeneic antigen-presenting cells.	J Exp Med	1982	https://conductscience.org/library/papers/6980258	PubMed
6,973,002	H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.	J Exp Med	1981	https://conductscience.org/library/papers/6973002	PubMed
6,967,190	MHC restriction, self-tolerance and the thymus.	Nature	1980	https://conductscience.org/library/papers/6967190	PubMed
6,965,308	Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.	J Exp Med	1980	https://conductscience.org/library/papers/6965308	PubMed
6,792,318	Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.	J Exp Med	1981	https://conductscience.org/library/papers/6792318	PubMed

1 to 10 of 31

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Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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