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Paper · 6934545

A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.

Peltonen L and 2 others. Proc Natl Acad Sci U S A, 1980. Cited by 68 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide. Papers, record 6934545. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6934545

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1980
PubMed
Publication types
Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
68
iCite
Relative citation ratio, by iCite
2.2
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Peltonen LL
2Palotie AA
3Prockop DJD J

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GlycoproteinsMajor topic
Osteogenesis ImperfectaMajor topic
ProcollagenMajor topic
Cells, Cultured
Culture Media
Humans
Male
Mannose
Mutation

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
AM-16,516NIADDK NIH HHSUnited StatesPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,054,840Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/1054840PubMed
21,084,290Amino acid substitution Glu leads to Lys alpha1-antitrypsin PiZ.FEBS Lett1976https://conductscience.org/library/papers/1084290PubMed
316,068,188High cell density alters the ratio of type III to I collagen synthesis by fibroblasts.Nature1979https://conductscience.org/library/papers/16068188PubMed
41,069,290Simultaneous synthesis of types I and III collagen by fibroblasts in culture.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1069290PubMed
5446,751Synthesis and degradation of collagen by skin fibroblasts from controls and from patients with osteogenesis imperfecta.FEBS Lett1979https://conductscience.org/library/papers/446751PubMed
636,559The biosynthesis of collagen and its disorders (second of two parts).N Engl J Med1979https://conductscience.org/library/papers/36559PubMed
7227,854The distribution and initial characterization of oligosaccharide units on the COOH-terminal propeptide extensions of the pro-alpha 1 and pro-alpha 2 chains of type I procollagen.J Biol Chem1979https://conductscience.org/library/papers/227854PubMed
81,083,527Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1083527PubMed
9168,490Characterization of alpha1-antitrypsin in the inclusion bodies from the liver in alpha 1-antitrypsin deficiency.N Engl J Med1975https://conductscience.org/library/papers/168490PubMed
104,126,636Letter: Defect in alpha1-antitrypsin deficiency.Lancet1973https://conductscience.org/library/papers/4126636PubMed

1 to 10 of 24

See all 24 references

Cited by19

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 68 citations.

PMIDTitleJournalYearIn PapersSource
29,632,050The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.J Cell Sci2018https://conductscience.org/library/papers/29632050PubMed
19,651,044Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils.Biophys J2009https://conductscience.org/library/papers/19651044PubMed
18,248,096ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.PLoS Genet2008https://conductscience.org/library/papers/18248096PubMed
6,946,461Reduced secretion of structurally abnormal type I procollagen in a form of osteogenesis imperfecta.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6946461PubMed
6,876,111Heterogeneity of osteogenesis imperfecta type I.J Med Genet1983https://conductscience.org/library/papers/6876111PubMed
6,745,923Osteogenesis imperfecta: a heterogeneous morphologic phenotype in cultured dermal fibroblasts.Hum Genet1984https://conductscience.org/library/papers/6745923PubMed
6,615,420Altered glycosaminoglycan production in cultured osteogenesis-imperfecta skin fibroblasts.Biochem J1983https://conductscience.org/library/papers/6615420PubMed
6,421,277Abnormal type I collagen metabolism by cultured fibroblasts in lethal perinatal osteogenesis imperfecta.Biochem J1984https://conductscience.org/library/papers/6421277PubMed
6,411,063Analysis of cyanogen bromide peptides of type I collagen from a patient with lethal osteogenesis imperfecta.Biochem J1983https://conductscience.org/library/papers/6411063PubMed
6,375,355Osteogenesis imperfecta: phenotypic heterogeneity, protein suicide, short and long collagen.Am J Hum Genet1984https://conductscience.org/library/papers/6375355PubMed

1 to 10 of 19

See all 19 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
COL1A21,278PubTator's text mininghttps://conductscience.org/library/genes/1278NCBI Gene
COL3A11,281PubTator's text mininghttps://conductscience.org/library/genes/1281NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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