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Paper · 6969778

In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity.

Delovitch TL and 5 others. J Exp Med, 1981. Cited by 42 papers, by iCite.

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ConductScience Library. In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity. Papers, record 6969778. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6969778

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity.
PubMed
Journal
J Exp Med
PubMed
Year
1981
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
42
iCite
Relative citation ratio, by iCite
0.94
iCite
Revised in PubMed
2019-05-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Delovitch TLT L
2Watson JJ
3Battistella RR
4Harris JFJ F
5Shaw JJ
6Paetkau VV

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
H-2 AntigensMajor topic
Lymphocyte CooperationMajor topic
LymphokinesMajor topic
T-LymphocytesMajor topic
Animals
Growth Substances
Histocompatibility Antigens Class II
Mice
Receptors, Immunologic

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
AI-13383NIAID NIH HHSUnited StatesR01AI013383PubMed and NIH

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1137,268Specific binding of K- and I-region products of the H-2 complex to activated thymus-derived (T) cells belonging to different Ly subclasses.J Exp Med1976https://conductscience.org/library/papers/137268PubMed
283,698Role of H-2 gene products in the function of T helper cells from normal and chimeric mice in vivo.Immunol Rev1978https://conductscience.org/library/papers/83698PubMed
3300,350Lymphocytes as models for the study of mammalian cellular differentiation.Immunol Rev1977https://conductscience.org/library/papers/300350PubMed
470,488Activation of T and B lymphocytes in vitro. VI. Biochemical and physicochemical characterization of the allogeneic effect factor.J Immunol1977https://conductscience.org/library/papers/70488PubMed
5302,311In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor-allogeneic effect factor.J Exp Med1977https://conductscience.org/library/papers/302311PubMed
66,965,968Cellular origins of co-stimulator (IL2) and its activity in cytotoxic T lymphocyte responses.J Immunol1980https://conductscience.org/library/papers/6965968PubMed
783,701Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.Immunol Rev1978https://conductscience.org/library/papers/83701PubMed
8216,692Genetic and sialylation sources of heterogeneity of the murine leukemia virus membrane envelope glycoproteins gp69/71.J Biol Chem1979https://conductscience.org/library/papers/216692PubMed
9310,835Immunochemical characterization of the Ly-8.2 murine lymphocyte alloantigen: possible relationship to actin.J Immunol1979https://conductscience.org/library/papers/310835PubMed
1033,223
The role of H-2 and Ia antigens in graft-versus-host reactions (GVHR). Presence of host alloantigens on donor cells after GVHR and suppression of GVHR with an anti-Ia antiserum against hose Ia antigens.
J Exp Med1979https://conductscience.org/library/papers/33223PubMed

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 42 citations.

PMIDTitleJournalYearIn PapersSource
7,038,025T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.J Exp Med1982https://conductscience.org/library/papers/7038025PubMed
7,033,438Role of Ia antigens in graft vs. host reactions. II. Molecular and functional analysis of T cell alloreactivity by the characterization of host Ia antigens on alloactivated donor T cells.J Exp Med1982https://conductscience.org/library/papers/7033438PubMed
6,801,177Requirement for three signals in "T-independent" (lipopolysaccharide-induced) as well as in T-dependent B cell responses.J Exp Med1982https://conductscience.org/library/papers/6801177PubMed
6,787,607T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6787607PubMed
6,705,266Injection of mouse thyroglobulin and/or adult thymectomy do not break tolerance to thyroglobulin during the lupus like graft versus host disease in mice.Clin Exp Immunol1984https://conductscience.org/library/papers/6705266PubMed
6,600,516Induction of a B-lymphocyte receptor for a T cell-replacing factor by the crosslinking of surface IgD.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6600516PubMed
6,600,488T cell-derived B cell growth and differentiation factors. Dichotomy between the responsiveness of B cells from adult and neonatal mice.J Exp Med1983https://conductscience.org/library/papers/6600488PubMed
6,461,714
Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease.
J Exp Med1982https://conductscience.org/library/papers/6461714PubMed
6,227,066I-J subregion and suppressor signals.Surv Immunol Res1982https://conductscience.org/library/papers/6227066PubMed
6,225,177T-cell hyperreactivity of NZB mice against H-2 identical cells. Equal cytotoxic T lymphocyte precursor frequency against H-2 allogeneic and H-2 syngeneic target cells in NZB.Rheumatol Int1983https://conductscience.org/library/papers/6225177PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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