Paper6972040

Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection.

Green WF and 1 other. Proc Natl Acad Sci U S A, 1981. Cited by 70 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection. Papers, record 6972040. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6972040

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6972040/; PubMed
DOI: https://doi.org/10.1073/pnas.78.2.1152; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC319965/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 70; iCite
Relative citation ratio, by iCite: 2.17; iCite
Revised in PubMed: 2021-12-03; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Green WF	W F
2	Colley DG	D G

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Granuloma	Major topic
Liver Diseases	Major topic
Ovum	Major topic
Schistosoma mansoni	Major topic
T-Lymphocytes	Major topic
Animals
Female
Hemagglutination Tests
Immunosuppression Therapy
Male
Mice
Mice, Inbred CBA
Spleen

Source PubMed

Show 7 more topicsShow fewer topics

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AI 05757-02	NIAID NIH HHS	United States		PubMed	PubMed
AI 11289	NIAID NIH HHS	United States	R01AI011289	PubMed and NIH	NIH RePORTER
			F32AI005757	NIH	NIH RePORTER
			R22AI011289	NIH	NIH RePORTER
			R37AI011289	NIH	NIH RePORTER

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	72,775	Specific enrichment of the suppressor T cell bearing I-J determinants: parallel functional and serological characterizations.	J Exp Med	1977	https://conductscience.org/library/papers/72775	PubMed
2	14,117,555	WARREN KS: MILD PROLONGED SCHISTOSOMIASIS IN MICE: ALTERATIONS IN HOST RESPONSE WITH TIME AND THE DEVELOPMENT OF PORTAL FIBROSIS.	Trans R Soc Trop Med Hyg	1964	https://conductscience.org/library/papers/14117555	PubMed
3	5,920,326	The pathogenesis of "clay-pipe stem cirrhosis" in mice with chronic schistosomiasis mansoni, with a note on the longevity of the schistosomes.	Am J Pathol	1966	https://conductscience.org/library/papers/5920326	PubMed
4	6,054,847	Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.	Am J Pathol	1967	https://conductscience.org/library/papers/6054847	PubMed
5	5,635,858	Endogenous desensitization: changing host granulomatou response to schistosome eggs at different stages of infection with schistosoma mansoni.	Am J Pathol	1968	https://conductscience.org/library/papers/5635858	PubMed
6	5,535,626	Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs.	J Exp Med	1970	https://conductscience.org/library/papers/5535626	PubMed
7	4,558,286	The immunopathogenesis of schistosomiasis: a multidisciplinary approach.	Trans R Soc Trop Med Hyg	1972	https://conductscience.org/library/papers/4558286	PubMed
8	804,513	Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni.	J Immunol	1975	https://conductscience.org/library/papers/804513	PubMed
9	1,171,139	Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni.	J Immunol	1975	https://conductscience.org/library/papers/1171139	PubMed
10	942,994	Adoptive suppression of granuloma formation.	J Exp Med	1976	https://conductscience.org/library/papers/942994	PubMed
11	1,085,338	A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.	J Exp Med	1976	https://conductscience.org/library/papers/1085338	PubMed
12	68,991	Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT) II. Presence of I-J determinants on the GT-suppressive factor.	J Exp Med	1977	https://conductscience.org/library/papers/68991	PubMed
13	68,992	The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride.	J Exp Med	1977	https://conductscience.org/library/papers/68992	PubMed
14	410,029	Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/410029	PubMed
15	339,757	Modulation of immunopathology and disease in schistosomiasis.	Am J Trop Med Hyg	1977	https://conductscience.org/library/papers/339757	PubMed
16	306,405	Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.	J Exp Med	1978	https://conductscience.org/library/papers/306405	PubMed
17	306,406	Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.	J Exp Med	1978	https://conductscience.org/library/papers/306406	PubMed
18	307,988	Cellular interaction between cytotoxic and suppressor T cells against syngeneic tumors in the mouse.	Cell Immunol	1978	https://conductscience.org/library/papers/307988	PubMed
19	79,609	Antigen-specific T cell-mediated suppression. II. In vitro induction by I-J-coded L-glutamic acid50-L-tyrosine50 (GT)-specific T cell suppressor factor (GT-T8F) of suppressor T cells (T82) bearing distinct I-J determinants.	J Immunol	1978	https://conductscience.org/library/papers/79609	PubMed
20	308,970	Regulation of delayed-type hypersensitivity reactions by cyclophosphamide-sensitive T cells.	J Immunol	1978	https://conductscience.org/library/papers/308970	PubMed

Show 14 more referencesShow fewer referencesSee all 31 references

Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 70 citations.

PMID	Title	Journal	Year	In Papers	Source
22,405,002	Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.	Structure	2012	https://conductscience.org/library/papers/22405002	PubMed
6,947,275	In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6947275	PubMed
6,795,305	In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.	J Exp Med	1981	https://conductscience.org/library/papers/6795305	PubMed
6,587,370	Schistosoma mansoni egg granuloma size reduction in challenged baboons after vaccination with irradiated cryopreserved schistosomula.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6587370	PubMed
6,578,293	Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.	J Exp Med	1983	https://conductscience.org/library/papers/6578293	PubMed
6,409,803	Immunogenetics of BCG-induced anergy in mice. Control by Igh- and H-2-linked genes.	Immunology	1983	https://conductscience.org/library/papers/6409803	PubMed
6,304,228	Enhancement of the intensity, persistence, and passive transfer of delayed-type hypersensitivity lesions by pertussigen in mice.	J Exp Med	1983	https://conductscience.org/library/papers/6304228	PubMed
6,293,112	Regulation of the immune response to antigens on the malignant cell surface.	Springer Semin Immunopathol	1982	https://conductscience.org/library/papers/6293112	PubMed
6,227,066	I-J subregion and suppressor signals.	Surv Immunol Res	1982	https://conductscience.org/library/papers/6227066	PubMed
6,217,278	Regulation of granulomatous inflammation in murine schistosomiasis. II. T suppressor cell-derived, I-C subregion-encoded soluble suppressor factor mediates regulation of lymphokine production.	J Exp Med	1983	https://conductscience.org/library/papers/6217278	PubMed
6,215,458	Mechanism responsible for the induction of I-J restriction on TS3 suppressor cells.	J Exp Med	1982	https://conductscience.org/library/papers/6215458	PubMed
6,215,456	I-J-restricted interactions in the generation of azobenzenearsonate-specific suppressor T cells.	J Exp Med	1982	https://conductscience.org/library/papers/6215456	PubMed
6,205,592	Distribution and kinetics of mononuclear phagocytes in granulomas elicited by eggs of Schistosoma mansoni.	Am J Pathol	1984	https://conductscience.org/library/papers/6205592	PubMed
6,182,106	Immunoregulation in disseminated histoplasmosis: characterization of the surface phenotype of splenic suppressor T lymphocytes.	Infect Immun	1982	https://conductscience.org/library/papers/6182106	PubMed
3,093,535	Immune responses during human Schistosomiasis mansoni. Evidence for antiidiotypic T lymphocyte responsiveness.	J Clin Invest	1986	https://conductscience.org/library/papers/3093535	PubMed
3,009,850	Regulation of herpes simplex virus-specific cell-mediated immunity by a specific suppressor factor.	J Virol	1986	https://conductscience.org/library/papers/3009850	PubMed
2,504,481	Immunopathology of Schistosoma mansoni infection.	Clin Microbiol Rev	1989	https://conductscience.org/library/papers/2504481	PubMed
1,900,066	Splenic and granuloma T-lymphocyte responses to fractionated soluble egg antigens of Schistosoma mansoni-infected mice.	Infect Immun	1991	https://conductscience.org/library/papers/1900066	PubMed

Show 12 more cited byShow fewer cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Trials
Comments and corrections
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/6972040

GET https://conductscience.org/api/papers/v1/6972040/references?page=2

API reference For AI assistants