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Paper75232

A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.

Engleman EG and 3 others. J Exp Med, 1978. Cited by 112 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression. Papers, record 75232. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75232

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
112
iCite
Relative citation ratio, by iCite
3.33
iCite
Revised in PubMed
2021-12-03
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Engleman EGE G
2McMichael AJA J
3Batey MEM E
4McDevitt HOH O

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
HLA AntigensMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
Dose-Response Relationship, Radiation
Epitopes
Female
Humans
Lymphocyte Culture Test, Mixed
Male
Phenotype
Pregnancy

Source PubMed

References5

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
2129,500Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.J Exp Med1976https://conductscience.org/library/papers/129500PubMed
34,399,834Three closely linked genetic systems relevant to transplantation.Proc Natl Acad Sci U S A1971https://conductscience.org/library/papers/4399834PubMed
453,264Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.J Exp Med1975https://conductscience.org/library/papers/53264PubMed
555,436Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).J Immunol1976https://conductscience.org/library/papers/55436PubMed

Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 112 citations.

PMIDTitleJournalYearIn PapersSource
25,191,324Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.Front Immunol2014https://conductscience.org/library/papers/25191324PubMed
16,068,184Structural polymorphism of human DR antigens.Nature1979https://conductscience.org/library/papers/16068184PubMed
7,025,308HLA restriction of human cytotoxic T cells.Springer Semin Immunopathol1980https://conductscience.org/library/papers/7025308PubMed
6,979,605Anti-Ia antibody in the sera of normal subjects after in vivo antigenic stimulation.J Exp Med1982https://conductscience.org/library/papers/6979605PubMed
6,459,995Regulation of the human allogeneic proliferative response in vitro.Immunogenetics1981https://conductscience.org/library/papers/6459995PubMed
6,459,991
Genetic control of allogeneic interactions in the guinea-pig. IV. The specific elimination of MLC suppressor cells by the in vivo administration of antisera against a GPLA-B region-controlled determinant.
Immunology1982https://conductscience.org/library/papers/6459991PubMed
6,455,224Amplification and suppression of human T cell proliferative responses by alloactivated T cells.Clin Exp Immunol1981https://conductscience.org/library/papers/6455224PubMed
6,454,646Regulation of human cytotoxic lymphocyte responses. I. Non-cytolytic suppression mediated by alloantigen-activated cells.Immunology1981https://conductscience.org/library/papers/6454646PubMed
6,237,121Spinal fluid lymphocytes responsive to autologous and allogeneic cells in multiple sclerosis and control individuals.J Clin Invest1984https://conductscience.org/library/papers/6237121PubMed
6,230,305Reactivity pattern of 15 HLA-Dw1 homozygous typing cells in primary mixed lymphocyte culture.Hum Genet1984https://conductscience.org/library/papers/6230305PubMed
6,229,476Suppression of the mixed lymphocyte reaction by alloantigen-primed and -stimulated human spleen lymphocytes.Immunology1984https://conductscience.org/library/papers/6229476PubMed
6,223,112Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus.J Exp Med1983https://conductscience.org/library/papers/6223112PubMed
6,212,626
Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation.
J Exp Med1982https://conductscience.org/library/papers/6212626PubMed
6,187,690HLA-restricted T lymphocyte-mediated cytotoxicity against herpes simplex virus-infected cells in humans.Infect Immun1983https://conductscience.org/library/papers/6187690PubMed
3,859,460HLA-DR antigens in primary biliary cirrhosis: lack of association.Gut1985https://conductscience.org/library/papers/3859460PubMed
2,788,125Phenotypic characterization of macrophages in human term placenta.Immunology1989https://conductscience.org/library/papers/2788125PubMed
2,420,496AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens.Clin Exp Immunol1986https://conductscience.org/library/papers/2420496PubMed
2,419,245Gestational immunosuppression is mediated by specific Lyt 2+ T cells.Immunology1986https://conductscience.org/library/papers/2419245PubMed
453,325Immunologic and genetic factors influencing reproduction. A review.Am J Pathol1979https://conductscience.org/library/papers/453325PubMed
374,261
Development of antigen-induced proliferative responsiveness by murine lymph node cells. I. Identification of differences in the in vitro proliferative responses during a first and a second period of responsiveness.
Immunology1979https://conductscience.org/library/papers/374261PubMed

See all 25 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
HLA-A3,105PubTator's text mininghttps://conductscience.org/library/genes/3105NCBI Gene
HLA-B3,106PubTator's text mininghttps://conductscience.org/library/genes/3106NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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