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Paper · 804137

Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.

Gerich JE and 6 others. N Engl J Med, 1975. Cited by 371 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. Papers, record 804137. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/804137

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.
PubMed
Journal
N Engl J Med
PubMed
Year
1975
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
371
iCite
Relative citation ratio, by iCite
11
iCite
Revised in PubMed
2018-12-03
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gerich JEJ E
2Lorenzi MM
3Bier DMD M
4Schneider VV
5Tsalikian EE
6Karam JHJ H
7Forsham PHP H

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Diabetic KetoacidosisMajor topic
GlucagonMajor topic
PeptidesMajor topic
Adult
Alanine
Blood Glucose
Depression, Chemical
Diabetes Mellitus, Type 1
Fatty Acids, Nonesterified
Glycerol
Growth Hormone
Humans
Hydrocortisone
Hydroxybutyrates
Hyperglycemia
Insulin
Ketone Bodies
Lactates
Male
Substance Withdrawal Syndrome

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by88

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 371 citations.

PMIDTitleJournalYearIn PapersSource
41,555,777Unraveling A-β+ ketosis-prone diabetes: An evolving diagnosis with an elusive pathogenesis.J Diabetes Investig2026https://conductscience.org/library/papers/41555777PubMed
41,172,278Altered Glucagon Response to Oral Glucose in Individuals at Different Stages of Type 1 Diabetes Development.J Clin Endocrinol Metab2026https://conductscience.org/library/papers/41172278PubMed
41,006,196Children With Pancreatic Hypoplasia Experience Poor Weight Gain and Labile Diabetes but Low Incidence of DKA.J Clin Endocrinol Metab2026https://conductscience.org/library/papers/41006196PubMed
40,822,953Glucagon in metabolic disease: a mini-review of emerging multi-organ roles beyond glycemic control.Front Endocrinol (Lausanne)2025https://conductscience.org/library/papers/40822953PubMed
40,771,639REVISITING GLUCAGON ACTION IN DIABETES: IS IT ALL BAD?Trans Am Clin Climatol Assoc2025https://conductscience.org/library/papers/40771639PubMed
40,099,572Dehydration-induced AVP stimulates glucagon release and ketogenesis.Am J Physiol Endocrinol Metab2025https://conductscience.org/library/papers/40099572PubMed
39,803,760Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes.Acta Physiol (Oxf)2025https://conductscience.org/library/papers/39803760PubMed
39,172,148GLP-1 mimetics and diabetic ketoacidosis: possible interactions and clinical consequences.Naunyn Schmiedebergs Arch Pharmacol2025https://conductscience.org/library/papers/39172148PubMed
39,068,220Directed differentiation of pancreatic δ cells from human pluripotent stem cells.Nat Commun2024https://conductscience.org/library/papers/39068220PubMed
38,579,751Glucagon resistance and metabolic-associated steatotic liver disease: a review of the evidence.J Endocrinol2024https://conductscience.org/library/papers/38579751PubMed

1 to 10 of 88

See all 88 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
SST6,750PubTator's text mininghttps://conductscience.org/library/genes/6750NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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