Paper · 8062832

A transcriptional silencer controls the developmental expression of the CD4 gene.

Siu G and 4 others. EMBO J, 1994. Cited by 165 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A transcriptional silencer controls the developmental expression of the CD4 gene. Papers, record 8062832. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8062832

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A transcriptional silencer controls the developmental expression of the CD4 gene.; PubMed
Journal: EMBO J; PubMed
Year: 1994; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8062832/; PubMed
DOI: https://doi.org/10.1002/j.1460-2075.1994.tb06664.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC395261/; PubMed
The journal: https://conductscience.org/library/journal-index/8208664; PubMed
Citations, by iCite: 165; iCite
Relative citation ratio, by iCite: 2.49; iCite
Revised in PubMed: 2022-05-11; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Siu G	G
2	Wurster AL	A L
3	Duncan DD	D D
4	Soliman TM	T M
5	Hedrick SM	S M

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
CD4 Antigens	Major topic
Gene Expression Regulation	Major topic
Regulatory Sequences, Nucleic Acid	Major topic
T-Lymphocyte Subsets	Major topic
Animals
CD8 Antigens
Cells, Cultured
Enhancer Elements, Genetic
Genetic Markers
HLA-B7 Antigen
Humans
Mice
Mice, Transgenic
Models, Genetic
Promoter Regions, Genetic
Spleen
Thymus Gland
Transcription, Genetic

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
AI29990	NIAID NIH HHS	United States	R01AI029990	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References67

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	8,097,522	Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.	J Exp Med	1993	https://conductscience.org/library/papers/8097522	PubMed
2	8,355,705	A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.	Mol Cell Biol	1993	https://conductscience.org/library/papers/8355705	PubMed
3	8,356,078	Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins.	Proc Natl Acad Sci U S A	1993	https://conductscience.org/library/papers/8356078	PubMed
4	2,493,727	Molecular and cellular events of T cell development.	Adv Immunol	1989	https://conductscience.org/library/papers/2493727	PubMed
5	2,493,728	Molecular biology and function of CD4 and CD8.	Adv Immunol	1989	https://conductscience.org/library/papers/2493728	PubMed
6	2,924,354	The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner.	Cell	1989	https://conductscience.org/library/papers/2924354	PubMed
7	2,476,238	Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.	Cell	1989	https://conductscience.org/library/papers/2476238	PubMed
8	2,571,940	Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor.	Nature	1989	https://conductscience.org/library/papers/2571940	PubMed
9	2,582,491	Alpha beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers.	Cell	1989	https://conductscience.org/library/papers/2582491	PubMed
10	2,685,559	A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block.	Mol Cell Biol	1989	https://conductscience.org/library/papers/2685559	PubMed

1 to 10 of 67

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Cited by51

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 165 citations.

PMID	Title	Journal	Year	In Papers	Source
40,580,963	A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation.	Dev Cell	2025	https://conductscience.org/library/papers/40580963	PubMed
40,112,175	Genome-Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells.	Adv Sci (Weinh)	2025	https://conductscience.org/library/papers/40112175	PubMed
39,882,239	A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error.	Front Immunol	2024	https://conductscience.org/library/papers/39882239	PubMed
36,344,659	Identification of non-coding silencer elements and their regulation of gene expression.	Nat Rev Mol Cell Biol	2023	https://conductscience.org/library/papers/36344659	PubMed
35,563,864	Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers.	Cells	2022	https://conductscience.org/library/papers/35563864	PubMed
35,064,205	An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice.	Commun Biol	2022	https://conductscience.org/library/papers/35064205	PubMed
32,094,911	Systematic identification of silencers in human cells.	Nat Genet	2020	https://conductscience.org/library/papers/32094911	PubMed
32,094,910	Silencers in the spotlight.	Nat Genet	2020	https://conductscience.org/library/papers/32094910	PubMed
30,295,892	Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.	Mol Biol Evol	2019	https://conductscience.org/library/papers/30295892	PubMed
30,185,787	Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.	Nat Commun	2018	https://conductscience.org/library/papers/30185787	PubMed

1 to 10 of 51

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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