Paper · 8097522
Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.
Blum MD and 4 others. J Exp Med, 1993. Cited by 43 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. Papers, record 8097522. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8097522
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics16
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| CD4 Antigens | Major topic |
| CD4-Positive T-Lymphocytes | Major topic |
| Enhancer Elements, Genetic | Major topic |
| Gene Expression Regulation | Major topic |
| Thymus Gland | Major topic |
| Animals | |
| B-Lymphocytes | |
| Base Sequence | |
| Cell Differentiation | |
| DNA | |
| Humans | |
| Mice | |
| Mice, Transgenic | |
| Molecular Sequence Data | |
| Sequence Homology, Nucleic Acid | |
| Spleen |
Source PubMed
Grants2
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| AI-30502 | NIAID NIH HHS | United States | R01AI030502 | PubMed and NIH | NIH RePORTER |
| NS-25129 | NINDS NIH HHS | United States | R01NS025129 | PubMed and NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References63
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,901,264 | Development of the CD4 and CD8 lineage of T cells: instruction versus selection. | EMBO J | 1991 | https://conductscience.org/library/papers/1901264 | PubMed |
| 2 | 2,990,730 | The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. | Cell | 1985 | https://conductscience.org/library/papers/2990730 | PubMed |
| 3 | 2,083,253 | Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. | New Biol | 1990 | https://conductscience.org/library/papers/2083253 | PubMed |
| 4 | 1,673,361 | CD8 is needed for development of cytotoxic T cells but not helper T cells. | Cell | 1991 | https://conductscience.org/library/papers/1673361 | PubMed |
| 5 | 1,906,921 | Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies. | J Exp Med | 1991 | https://conductscience.org/library/papers/1906921 | PubMed |
| 6 | 1,652,099 | Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules. | Nature | 1991 | https://conductscience.org/library/papers/1652099 | PubMed |
| 7 | 1,908,563 | Co-engagement of CD8 with the T cell receptor is required for negative selection. | Nature | 1991 | https://conductscience.org/library/papers/1908563 | PubMed |
| 8 | 1,889,086 | Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site. | Cell | 1991 | https://conductscience.org/library/papers/1889086 | PubMed |
| 9 | 1,909,605 | Mice lacking MHC class II molecules. | Cell | 1991 | https://conductscience.org/library/papers/1909605 | PubMed |
| 10 | 1,832,488 | Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. | Nature | 1991 | https://conductscience.org/library/papers/1832488 | PubMed |
1 to 10 of 63
See all 63 referencesCited by10
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 43 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 21,989,924 | The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. | Curr Top Microbiol Immunol | 2012 | https://conductscience.org/library/papers/21989924 | PubMed |
| 11,305,358 | Use of human CD4 transgenic mice for studying immunogenicity of HIV-1 envelope protein gp120. | Transgenic Res | 2001 | https://conductscience.org/library/papers/11305358 | PubMed |
| 9,765,424 | CD4 promoter transactivation by human herpesvirus 6. | J Virol | 1998 | https://conductscience.org/library/papers/9765424 | PubMed |
| 9,501,224 | Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. | Proc Natl Acad Sci U S A | 1998 | https://conductscience.org/library/papers/9501224 | PubMed |
| 8,289,789 | Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice. | Mol Cell Biol | 1994 | https://conductscience.org/library/papers/8289789 | PubMed |
| 8,062,832 | A transcriptional silencer controls the developmental expression of the CD4 gene. | EMBO J | 1994 | https://conductscience.org/library/papers/8062832 | PubMed |
| 8,016,129 | Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. | Proc Natl Acad Sci U S A | 1994 | https://conductscience.org/library/papers/8016129 | PubMed |
| 7,935,370 | Elf-1 binds to a critical element in a second CD4 enhancer. | Mol Cell Biol | 1994 | https://conductscience.org/library/papers/7935370 | PubMed |
| 7,760,814 | A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. | Mol Cell Biol | 1995 | https://conductscience.org/library/papers/7760814 | PubMed |
| 7,586,702 | Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor (TNF) and IL-1 beta. | Clin Exp Immunol | 1995 | https://conductscience.org/library/papers/7586702 | PubMed |
Genes4
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CD4 | 920 | PubTator's text mining | https://conductscience.org/library/genes/920 | NCBI Gene |
| CD8A | 925 | PubTator's text mining | https://conductscience.org/library/genes/925 | NCBI Gene |
| LAG3 | 3,902 | PubTator's text mining | https://conductscience.org/library/genes/3902 | NCBI Gene |
| TRBV20OR9-2 | 6,962 | PubTator's text mining | https://conductscience.org/library/genes/6962 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data1
The data bank entries PubMed's record names. Trial numbers are under Trials.
| Data bank | Accession |
|---|---|
| GENBANK | M75688 |
Source GENBANK
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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