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Paper · 8943005

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

Alcorta DA and 5 others. Proc Natl Acad Sci U S A, 1996. Cited by 825 papers, by iCite.

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ConductScience Library. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Papers, record 8943005. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8943005

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1996
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
825
iCite
Relative citation ratio, by iCite
16.2
iCite
Revised in PubMed
2022-03-09
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Alcorta DAD A
2Xiong YY
3Phelps DD
4Hannon GG
5Beach DD
6Barrett JCJ C

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carrier ProteinsMajor topic
Cell Cycle ProteinsMajor topic
Cellular SenescenceMajor topic
Proto-Oncogene ProteinsMajor topic
SkinMajor topic
Tumor Suppressor ProteinsMajor topic
Cell Division
Cell Line
Cells, Cultured
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinase Inhibitor p57
Cyclin-Dependent Kinases
Enzyme Inhibitors
Fibroblasts
Humans
Infant, Newborn
Male
Microtubule-Associated Proteins
Nuclear Proteins
Protein Binding
Protein Serine-Threonine Kinases
Recombinant Fusion Proteins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,646,779Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.Cell1996https://conductscience.org/library/papers/8646779PubMed
28,332,640Replicative senescence of human fibroblast-like cells in culture.Physiol Rev1993https://conductscience.org/library/papers/8332640PubMed
37,954,407Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.Cancer Res1994https://conductscience.org/library/papers/7954407PubMed
48,521,522Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.Cell1995https://conductscience.org/library/papers/8521522PubMed
57,777,060Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.Nature1995https://conductscience.org/library/papers/7777060PubMed
68,360,268Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts.J Cell Sci1993https://conductscience.org/library/papers/8360268PubMed
71,652,450A role for both RB and p53 in the regulation of human cellular senescence.Exp Cell Res1991https://conductscience.org/library/papers/1652450PubMed
88,620,534Role of the INK4a locus in tumor suppression and cell mortality.Cell1996https://conductscience.org/library/papers/8620534PubMed
97,538,902Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.Cancer Res1995https://conductscience.org/library/papers/7538902PubMed
108,706,801Differential CDK-inhibitor gene expression in aging human diploid fibroblasts.Exp Gerontol1996https://conductscience.org/library/papers/8706801PubMed

1 to 10 of 36

See all 36 references

Cited by377

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 825 citations.

PMIDTitleJournalYearIn PapersSource
42,827,203Cellular senescence: six decades of discovery and reinvention.EMBO J2026https://conductscience.org/library/papers/42827203PubMed
42,527,539Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nat Rev Genet2026https://conductscience.org/library/papers/42527539PubMed
42,469,200LARS regulates cellular senescence and autophagy in liver cancer cells.Cell Death Dis2026https://conductscience.org/library/papers/42469200PubMed
42,272,639Stem cell dysfunction and rejuvenation strategies in ageing: emerging advances in regenerative medicine.Front Cell Dev Biol2026https://conductscience.org/library/papers/42272639PubMed
42,020,722Identification of gradual aging and late-onset aging markers using male African turquoise killifish.Sci Rep2026https://conductscience.org/library/papers/42020722PubMed
41,758,785Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.PLoS One2026https://conductscience.org/library/papers/41758785PubMed
41,675,059Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities.iScience2026https://conductscience.org/library/papers/41675059PubMed
41,613,943Atrial myocyte senescence as a driver of atrial fibrillation: mechanisms and therapeutic implications.Front Cell Dev Biol2025https://conductscience.org/library/papers/41613943PubMed
41,543,765G1/S arrest: a key mechanism of cellular aging and replicative senescence.Biogerontology2026https://conductscience.org/library/papers/41543765PubMed
41,225,537Decoding cancer dormancy: integrative genomic, phenotypic and live-cell imaging analysis to reveal the hidden cancer cell reservoir.Mol Cancer2025https://conductscience.org/library/papers/41225537PubMed

1 to 10 of 377

See all 377 cited by

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CDK41,019PubTator's text mininghttps://conductscience.org/library/genes/1019NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
CDKN1C1,028PubTator's text mininghttps://conductscience.org/library/genes/1028NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
H3P16644,914PubTator's text mininghttps://conductscience.org/library/genes/644914NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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