Paper · 8971024
Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.
Lieber A and 3 others. J Virol, 1996. Cited by 194 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. Papers, record 8971024. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8971024
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.
- PubMed
- Publication types
- Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
- PubMed
Topics20
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adenoviruses, Human | Major topic |
| Bacteriophage P1 | Major topic |
| Genetic Vectors | Major topic |
| Integrases | Major topic |
| Viral Proteins | Major topic |
| Adenovirus E1 Proteins | |
| Animals | |
| Cell Line, Transformed | |
| DNA, Viral | |
| Female | |
| Gene Deletion | |
| HeLa Cells | |
| Humans | |
| Liver | |
| Mice | |
| Mice, Inbred C57BL | |
| Mice, SCID | |
| Recombination, Genetic | |
| Transfection | |
| Virus Replication |
Source PubMed
Grants1
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| DK49022 | NIDDK NIH HHS | United States | R01DK049022 | PubMed and NIH |
Source NIH RePORTER
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References62
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 8,825,158 | Method for multiple portal vein infusions in mice: quantitation of adenovirus-mediated hepatic gene transfer. | Biotechniques | 1996 | https://conductscience.org/library/papers/8825158 | PubMed |
| 2 | 8,794,347 | Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted. | J Virol | 1996 | https://conductscience.org/library/papers/8794347 | PubMed |
| 3 | 8,929,914 | Novel complementation cell lines derived from human lung carcinoma A549 cells support the growth of E1-deleted adenovirus vectors. | Gene Ther | 1996 | https://conductscience.org/library/papers/8929914 | PubMed |
| 4 | 4,713,914 | Studies on the mechanism of replication of adenovirus DNA. I. The effect of hydroxyurea. | Virology | 1973 | https://conductscience.org/library/papers/4713914 | PubMed |
| 5 | 211,182 | Infection of mouse liver by human adenovirus type 5. | J Gen Virol | 1978 | https://conductscience.org/library/papers/211182 | PubMed |
| 6 | 291,030 | An adenovirus type 5 early gene function regulates expression of other early viral genes. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/291030 | PubMed |
| 7 | 6,276,557 | Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. | J Mol Biol | 1981 | https://conductscience.org/library/papers/6276557 | PubMed |
| 8 | 6,286,831 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | J Mol Appl Genet | 1982 | https://conductscience.org/library/papers/6286831 | PubMed |
| 9 | 7,346,714 | Adenovirus chromatin structure at different stages of infection. | Mol Cell Biol | 1981 | https://conductscience.org/library/papers/7346714 | PubMed |
| 10 | 6,547,205 | Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. | Mol Cell Biol | 1984 | https://conductscience.org/library/papers/6547205 | PubMed |
1 to 10 of 62
See all 62 referencesCited by83
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 194 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,282,469 | Tackling cancer heterogeneity with systemically delivered oncolytic adenoviruses transcriptionally targeted with hybrid promoters. | Mol Ther Oncol | 2025 | https://conductscience.org/library/papers/41282469 | PubMed |
| 40,590,260 | Developing the next-generation of adenoviral vector vaccines. | Hum Vaccin Immunother | 2025 | https://conductscience.org/library/papers/40590260 | PubMed |
| 40,231,246 | In vivo HSC transduction in humanized mice mediated by novel capsid-modified HDAd vectors. | Mol Ther Methods Clin Dev | 2025 | https://conductscience.org/library/papers/40231246 | PubMed |
| 37,332,609 | Mouse models in colon cancer, inferences, and implications. | iScience | 2023 | https://conductscience.org/library/papers/37332609 | PubMed |
| 37,219,458 | Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication. | J Virol | 2023 | https://conductscience.org/library/papers/37219458 | PubMed |
| 36,099,304 | Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice. | PLoS One | 2022 | https://conductscience.org/library/papers/36099304 | PubMed |
| 31,705,806 | Adenovirus vectors in hematopoietic stem cell genome editing. | FEBS Lett | 2019 | https://conductscience.org/library/papers/31705806 | PubMed |
| 28,955,747 | Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis. | Biochem Biophys Rep | 2017 | https://conductscience.org/library/papers/28955747 | PubMed |
| 28,700,677 | Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells. | PLoS One | 2017 | https://conductscience.org/library/papers/28700677 | PubMed |
| 26,986,751 | Adenovirus-Mediated Expression of the p14 Fusion-Associated Small Transmembrane Protein Promotes Cancer Cell Fusion and Apoptosis In Vitro but Does Not Provide Therapeutic Efficacy in a Xenograft Mouse Model of Cancer. | PLoS One | 2016 | https://conductscience.org/library/papers/26986751 | PubMed |
1 to 10 of 83
See all 83 cited byGenes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| BCKDHA | 593 | PubTator's text mining | https://conductscience.org/library/genes/593 |
Source NCBI Gene
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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