Paper · 28700677

Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells.

Saha B and 1 other. PLoS One, 2017. Cited by 36 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells. Papers, record 28700677. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28700677

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells.; PubMed
Journal: PLoS One; PubMed
Year: 2017; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/28700677/; PubMed
DOI: https://doi.org/10.1371/journal.pone.0181012; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5507307/; PubMed
The journal: https://conductscience.org/library/journal-index/101285081; PubMed
Citations, by iCite: 36; iCite
Relative citation ratio, by iCite: 1.28; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Saha B	Bratati
2	Parks RJ	Robin J		https://orcid.org/0000-0002-4959-2233

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adenoviruses, Human	Major topic
DNA Replication	Major topic
Genetic Vectors	Major topic
Cell Line
DNA-Binding Proteins
Gene Products, pol
Hep G2 Cells
Humans
Viral Proteins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References59

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	8,971,024	Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.	J Virol	1996	https://conductscience.org/library/papers/8971024	PubMed
2	15,113,884	Activation of adenoviral gene expression by protein IX is not required for efficient virus replication.	J Virol	2004	https://conductscience.org/library/papers/15113884	PubMed
3	19,738,604	Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL.	Mol Ther	2010	https://conductscience.org/library/papers/19738604	PubMed
4	3,943,131	A mechanism for the control of protein synthesis by adenovirus VA RNAI.	Cell	1986	https://conductscience.org/library/papers/3943131	PubMed
5	6,310,869	Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein.	Virology	1983	https://conductscience.org/library/papers/6310869	PubMed
6	16,378,998	Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts.	J Virol	2006	https://conductscience.org/library/papers/16378998	PubMed
7	3,362,670	High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus.	Nucleic Acids Res	1988	https://conductscience.org/library/papers/3362670	PubMed
8	7,265,205	Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein.	J Mol Biol	1981	https://conductscience.org/library/papers/7265205	PubMed
9	21,307,207	Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression.	J Virol	2011	https://conductscience.org/library/papers/21307207	PubMed
10	15,769,610	Functions of the adenovirus E4 proteins and their impact on viral vectors.	Front Biosci	2005	https://conductscience.org/library/papers/15769610	PubMed

1 to 10 of 59

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Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 36 citations.

PMID	Title	Journal	Year	In Papers	Source
42,796,671	Target-Based Antiviral Drug Development Against Human Respiratory Viruses.	Pathogens	2026	https://conductscience.org/library/papers/42796671	PubMed
42,725,063	Adenovirus vector-mediated delivery of the CRISPR-CasRx system enables gene knockdown with suppressed collateral activity.	Mol Ther Nucleic Acids	2026	https://conductscience.org/library/papers/42725063	PubMed
42,129,074	The Pathology of Viral Infections.	Adv Exp Med Biol	2026	https://conductscience.org/library/papers/42129074	PubMed
41,383,016	A replication-incompetent adenovirus type 55 vaccine induces broad and durable protective immunity against pathogenic adenoviruses.	Mol Ther	2026	https://conductscience.org/library/papers/41383016	PubMed
41,081,511	Protein-S-nitrosylation of adenovirus-5 E1A and human papillomavirus 16 E7 limits their ability to inhibit STING activity.	J Virol	2025	https://conductscience.org/library/papers/41081511	PubMed
41,078,871	Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced in situ payload expression.	Mol Ther Methods Clin Dev	2025	https://conductscience.org/library/papers/41078871	PubMed
39,037,484	Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses.	J Microbiol	2024	https://conductscience.org/library/papers/39037484	PubMed
38,689,047	In Silico Intensive Analysis for the E4 Gene Evolution of Human Adenovirus Species D.	J Microbiol	2024	https://conductscience.org/library/papers/38689047	PubMed
38,523,676	Twenty years of Gendicine® rAd-p53 cancer gene therapy: The first-in-class human cancer gene therapy in the era of personalized oncology.	Genes Dis	2024	https://conductscience.org/library/papers/38523676	PubMed
38,338,787	Scanning the Horizon for Environmental Applications of Genetically Modified Viruses Reveals Challenges for Their Environmental Risk Assessment.	Int J Mol Sci	2024	https://conductscience.org/library/papers/38338787	PubMed

1 to 10 of 25

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Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CSRP3	8,048	PubTator's text mining	https://conductscience.org/library/genes/8048	NCBI Gene
DBT	1,629	PubTator's text mining	https://conductscience.org/library/genes/1629	NCBI Gene
GH1	2,688	PubTator's text mining	https://conductscience.org/library/genes/2688	NCBI Gene
PTPRU	10,076	PubTator's text mining	https://conductscience.org/library/genes/10076	NCBI Gene
RAD51	5,888	PubTator's text mining	https://conductscience.org/library/genes/5888	NCBI Gene
SNORA73A	6,080	PubTator's text mining	https://conductscience.org/library/genes/6080	NCBI Gene
SP1	6,667	PubTator's text mining	https://conductscience.org/library/genes/6667	NCBI Gene
TCF3	6,929	PubTator's text mining	https://conductscience.org/library/genes/6929	NCBI Gene
TRIM27	5,987	PubTator's text mining	https://conductscience.org/library/genes/5987	NCBI Gene
UBE2V1	7,335	PubTator's text mining	https://conductscience.org/library/genes/7335	NCBI Gene

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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