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Paper · 8979259

Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C.

Crane JK and 1 other. Mol Cell Biochem, 1996. Cited by 38 papers, by iCite.

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ConductScience Library. Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C. Papers, record 8979259. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8979259

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C.
PubMed
Journal
Mol Cell Biochem
PubMed
Year
1996
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
38
iCite
Relative citation ratio, by iCite
0.99
iCite
Revised in PubMed
2019-08-18
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Crane JKJ K
2Shanks KLK L

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ColonMajor topic
Escherichia coliMajor topic
Guanylate CyclaseMajor topic
Protein Kinase CMajor topic
Receptors, PeptideMajor topic
Bacterial Toxins
Binding Sites
Cell Line
Enterotoxins
Enzyme Activation
Escherichia coli Proteins
Humans
Peptides
Phorbol 12,13-Dibutyrate
Phosphorylation
Precipitin Tests
Receptors, Enterotoxin
Receptors, Guanylate Cyclase-Coupled

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R29 DK 49410NIDDK NIH HHSUnited StatesR29DK049410PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,416,985Activation and inhibition of protein kinase C isozymes alpha and beta by Gd3+.Arch Biochem Biophys1992https://conductscience.org/library/papers/1416985PubMed
28,100,232Receptors for Escherichia coli heat stable enterotoxin in human intestine and in a human intestinal cell line (Caco-2).J Cell Physiol1993https://conductscience.org/library/papers/8100232PubMed
31,656,772Characterization of the synergistic interaction of Escherichia coli heat-stable toxin and carbachol.Am J Physiol1991https://conductscience.org/library/papers/1656772PubMed
41,969,850Phorbol esters enhance the cyclic GMP response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa).Infect Immun1990https://conductscience.org/library/papers/1969850PubMed
51,360,449Regulation of intestinal guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) and protein kinase C.Infect Immun1992https://conductscience.org/library/papers/1360449PubMed
61,353,076Dephosphorylation of the guanylyl cyclase-A receptor causes desensitization.J Biol Chem1992https://conductscience.org/library/papers/1353076PubMed
72,873,144Phosphorylation of membrane-bound guanylate cyclase of sea urchin spermatozoa.J Cell Biol1986https://conductscience.org/library/papers/2873144PubMed
81,377,674Phosphorylation of the cystic fibrosis transmembrane conductance regulator.J Biol Chem1992https://conductscience.org/library/papers/1377674PubMed
92,521,487Protein kinase C substrates from bovine brain. Purification and characterization of neuromodulin, a neuron-specific calmodulin-binding protein.J Biol Chem1989https://conductscience.org/library/papers/2521487PubMed
102,153,665Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function.J Biol Chem1990https://conductscience.org/library/papers/2153665PubMed

1 to 10 of 40

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 38 citations.

PMIDTitleJournalYearIn PapersSource
35,525,553The pseudokinase domain in receptor guanylyl cyclases.Methods Enzymol2022https://conductscience.org/library/papers/35525553PubMed
33,470,843Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.Biomark Med2021https://conductscience.org/library/papers/33470843PubMed
24,967,239Current understanding of guanylin peptides actions.ISRN Nephrol2013https://conductscience.org/library/papers/24967239PubMed
24,006,470Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiol Mol Biol Rev2013https://conductscience.org/library/papers/24006470PubMed
23,269,669Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.J Biol Chem2013https://conductscience.org/library/papers/23269669PubMed
21,914,472Guanylyl cyclase structure, function and regulation.Cell Signal2011https://conductscience.org/library/papers/21914472PubMed
21,185,863Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.Pharmacol Ther2011https://conductscience.org/library/papers/21185863PubMed
19,960,363Receptor guanylyl cyclase C (GC-C): regulation and signal transduction.Mol Cell Biochem2010https://conductscience.org/library/papers/19960363PubMed
16,495,521Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coli.Infect Immun2006https://conductscience.org/library/papers/16495521PubMed
14,748,740Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.Biochem J2004https://conductscience.org/library/papers/14748740PubMed

1 to 10 of 13

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Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCY2,656PubTator's text mininghttps://conductscience.org/library/genes/2656NCBI Gene
GUCY2C2,984PubTator's text mininghttps://conductscience.org/library/genes/2984NCBI Gene
PRRT2112,476PubTator's text mininghttps://conductscience.org/library/genes/112476NCBI Gene
STAR6,770PubTator's text mininghttps://conductscience.org/library/genes/6770NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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