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Paper · 14748740

Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.

Ghanekar Y and 3 others. Biochem J, 2004. Cited by 26 papers, by iCite.

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ConductScience Library. Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity. Papers, record 14748740. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/14748740

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.
PubMed
Journal
Biochem J
PubMed
Year
2004
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
26
iCite
Relative citation ratio, by iCite
0.51
iCite
Revised in PubMed
2018-11-13
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ghanekar YYashoda
2Chandrashaker AAkhila
3Tatu UUtpal
4Visweswariah SSSandhya S

Source PubMed

Topics24

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Guanylate CyclaseMajor topic
Receptors, PeptideMajor topic
Amino Acid Sequence
Animals
Catalysis
Cell Line
Cell Membrane
Endoplasmic Reticulum
Galactose
Glycosylation
Half-Life
Humans
Ligands
Mannose
Molecular Sequence Data
Molecular Weight
N-Acetylglucosaminyltransferases
N-Acetylneuraminic Acid
Protein Conformation
Protein Processing, Post-Translational
Protein Transport
Receptors, Enterotoxin
Receptors, Guanylate Cyclase-Coupled
Trypsin

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References44

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,531,382Determination of the binding site on the extracellular domain of guanylyl cyclase C to heat-stable enterotoxin.J Biol Chem1999https://conductscience.org/library/papers/10531382PubMed
27,510,634Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.EMBO J1994https://conductscience.org/library/papers/7510634PubMed
38,797,807The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): relation of STa-mediated guanylyl cyclase activation and signaling by phorbol myristate acetate.FEBS Lett1996https://conductscience.org/library/papers/8797807PubMed
48,812,850Expression of the extracellular domain of the human heat-stable enterotoxin receptor in Escherichia coli and generation of neutralizing antibodies.Protein Expr Purif1996https://conductscience.org/library/papers/8812850PubMed
58,912,855Guanylyl cyclase C is up-regulated by nonparenchymal cells and hepatocytes in regenerating rat liver.Cancer Res1996https://conductscience.org/library/papers/8912855PubMed
68,945,558Identification of ligand recognition sites in heat-stable enterotoxin receptor, membrane-associated guanylyl cyclase C by site-directed mutational analysis.Infect Immun1996https://conductscience.org/library/papers/8945558PubMed
78,979,258Glycosylation is critical for natriuretic peptide receptor-B function.Mol Cell Biochem1996https://conductscience.org/library/papers/8979258PubMed
88,979,259Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C.Mol Cell Biochem1996https://conductscience.org/library/papers/8979259PubMed
98,997,239Structure, glycosylation, and localization of rat intestinal guanylyl cyclase C: modulation by fasting.Am J Physiol1996https://conductscience.org/library/papers/8997239PubMed
109,188,791Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.FEBS Lett1997https://conductscience.org/library/papers/9188791PubMed

1 to 10 of 44

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 26 citations.

PMIDTitleJournalYearIn PapersSource
40,801,095Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).Biochem J2025https://conductscience.org/library/papers/40801095PubMed
33,470,843Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.Biomark Med2021https://conductscience.org/library/papers/33470843PubMed
32,293,781Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations.IUBMB Life2020https://conductscience.org/library/papers/32293781PubMed
31,601,940Discovery of a receptor guanylate cyclase expressed in the sperm flagella of stony corals.Sci Rep2019https://conductscience.org/library/papers/31601940PubMed
27,481,254Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.Infect Immun2016https://conductscience.org/library/papers/27481254PubMed
23,269,669Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.J Biol Chem2013https://conductscience.org/library/papers/23269669PubMed
22,069,681Cure and curse: E. coli heat-stable enterotoxin and its receptor guanylyl cyclase C.Toxins (Basel)2010https://conductscience.org/library/papers/22069681PubMed
21,914,472Guanylyl cyclase structure, function and regulation.Cell Signal2011https://conductscience.org/library/papers/21914472PubMed
21,185,863Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.Pharmacol Ther2011https://conductscience.org/library/papers/21185863PubMed
19,960,363Receptor guanylyl cyclase C (GC-C): regulation and signal transduction.Mol Cell Biochem2010https://conductscience.org/library/papers/19960363PubMed

1 to 10 of 13

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GUCY2C2,984PubTator's text mininghttps://conductscience.org/library/genes/2984NCBI Gene
NPR34,883PubTator's text mininghttps://conductscience.org/library/genes/4883NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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