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Paper · 8945558

Identification of ligand recognition sites in heat-stable enterotoxin receptor, membrane-associated guanylyl cyclase C by site-directed mutational analysis.

Wada A and 6 others. Infect Immun, 1996. Cited by 32 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Identification of ligand recognition sites in heat-stable enterotoxin receptor, membrane-associated guanylyl cyclase C by site-directed mutational analysis. Papers, record 8945558. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8945558

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Identification of ligand recognition sites in heat-stable enterotoxin receptor, membrane-associated guanylyl cyclase C by site-directed mutational analysis.
PubMed
Journal
Infect Immun
PubMed
Year
1996
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
32
iCite
Relative citation ratio, by iCite
0.78
iCite
Revised in PubMed
2021-05-26
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wada AA
2Hirayama TT
3Kitaura HH
4Fujisawa JJ
5Hasegawa MM
6Hidaka YY
7Shimonishi YY

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
EnterotoxinsMajor topic
Escherichia coliMajor topic
Guanylate CyclaseMajor topic
IntestinesMajor topic
Receptors, PeptideMajor topic
Animals
Binding Sites
Hot Temperature
Intestinal Mucosa
Mutagenesis, Site-Directed
Mutation
Receptors, Enterotoxin
Receptors, Guanylate Cyclase-Coupled

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,432,063Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature1970https://conductscience.org/library/papers/5432063PubMed
21,382,057Ligand-independent oligomerization of natriuretic peptide receptors. Identification of heteromeric receptors and a dominant negative mutant.J Biol Chem1992https://conductscience.org/library/papers/1382057PubMed
3364,941Prediction of the secondary structure of proteins from their amino acid sequence.Adv Enzymol Relat Areas Mol Biol1978https://conductscience.org/library/papers/364941PubMed
4378,842Effect of purified Escherichia coli heat-stable enterotoxin on intestinal cyclic nucleotide metabolism and fluid secretion.Infect Immun1979https://conductscience.org/library/papers/378842PubMed
56,114,927Comparison of the biological actions of three purified heat-stable enterotoxins: effects on ion transport and guanylate cyclase activity in rabbit ileum in vitro.Infect Immun1981https://conductscience.org/library/papers/6114927PubMed
63,881,765Rapid and efficient site-specific mutagenesis without phenotypic selection.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3881765PubMed
74,041,144Biological and immunological characteristics of 125I-4Tyr and -18Tyr Escherichia coli heat-stable enterotoxin species purified by high-performance liquid chromatography.Anal Biochem1985https://conductscience.org/library/papers/4041144PubMed
82,455,217Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.Mol Cell Biol1988https://conductscience.org/library/papers/2455217PubMed
91,356,629Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands.Cell1992https://conductscience.org/library/papers/1356629PubMed
108,093,618Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine.J Biol Chem1993https://conductscience.org/library/papers/8093618PubMed

1 to 10 of 29

See all 29 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 32 citations.

PMIDTitleJournalYearIn PapersSource
36,770,798The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection.Molecules2023https://conductscience.org/library/papers/36770798PubMed
34,358,433Diarrheal pathogens trigger rapid evolution of the guanylate cyclase-C signaling axis in bats.Cell Host Microbe2021https://conductscience.org/library/papers/34358433PubMed
34,299,422
In Silico Prediction, Molecular Docking and Dynamics Studies of Steroidal Alkaloids of Holarrhena pubescens Wall. ex G. Don to Guanylyl Cyclase C: Implications in Designing of Novel Antidiarrheal Therapeutic Strategies.
Molecules2021https://conductscience.org/library/papers/34299422PubMed
33,470,843Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies.Biomark Med2021https://conductscience.org/library/papers/33470843PubMed
32,293,781Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations.IUBMB Life2020https://conductscience.org/library/papers/32293781PubMed
22,069,677Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection.Toxins (Basel)2010https://conductscience.org/library/papers/22069677PubMed
14,748,740Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.Biochem J2004https://conductscience.org/library/papers/14748740PubMed
12,813,912E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions.Trans Am Clin Climatol Assoc2003https://conductscience.org/library/papers/12813912PubMed
11,952,098Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C.Mol Cell Biochem2002https://conductscience.org/library/papers/11952098PubMed
11,083,812Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi.Infect Immun2000https://conductscience.org/library/papers/11083812PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
GUCY2C2,984PubTator's text mininghttps://conductscience.org/library/genes/2984

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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