Paper · 8093618

Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine.

Vaandrager AB and 3 others. J Biol Chem, 1993. Cited by 86 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine. Papers, record 8093618. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8093618

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine.; PubMed
Journal: J Biol Chem; PubMed
Year: 1993; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8093618/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 86; iCite
Relative citation ratio, by iCite: 2.23; iCite
Revised in PubMed: 2021-02-10; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Vaandrager AB	A B
2	Schulz S	S
3	De Jonge HR	H R
4	Garbers DL	D L

Source PubMed

Topics27

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Guanylate Cyclase	Major topic
Hot Temperature	Major topic
Intestinal Mucosa	Major topic
Receptors, Cell Surface	Major topic
Receptors, Peptide	Major topic
Adenosine Triphosphate
Amino Acid Sequence
Animals
Bacterial Toxins
Cell Line
Cyclic GMP
DNA
Drug Stability
Embryo, Mammalian
Enterotoxins
Escherichia coli Proteins
Gene Expression
Glycosylation
Humans
Kidney
Microvilli
Molecular Sequence Data
Rats
Receptors, Enterotoxin
Receptors, Guanylate Cyclase-Coupled
Recombinant Proteins
Transfection

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by21

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 86 citations.

PMID	Title	Journal	Year	In Papers	Source
40,801,095	Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).	Biochem J	2025	https://conductscience.org/library/papers/40801095	PubMed
28,090,568	Pathophysiology of Intestinal Na+/H+ exchange.	Cell Mol Gastroenterol Hepatol	2017	https://conductscience.org/library/papers/28090568	PubMed
22,069,681	Cure and curse: E. coli heat-stable enterotoxin and its receptor guanylyl cyclase C.	Toxins (Basel)	2010	https://conductscience.org/library/papers/22069681	PubMed
21,914,472	Guanylyl cyclase structure, function and regulation.	Cell Signal	2011	https://conductscience.org/library/papers/21914472	PubMed
21,185,863	Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.	Pharmacol Ther	2011	https://conductscience.org/library/papers/21185863	PubMed
20,962,002	Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.	J Physiol	2010	https://conductscience.org/library/papers/20962002	PubMed
19,960,363	Receptor guanylyl cyclase C (GC-C): regulation and signal transduction.	Mol Cell Biochem	2010	https://conductscience.org/library/papers/19960363	PubMed
19,800,103	Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas.	Hum Pathol	2010	https://conductscience.org/library/papers/19800103	PubMed
19,674,489	Abstracts of the 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications. Regensburg, Germany. June 19-21, 2009.	BMC Pharmacol	2009	https://conductscience.org/library/papers/19674489	PubMed
14,748,740	Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity.	Biochem J	2004	https://conductscience.org/library/papers/14748740	PubMed

1 to 10 of 21

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GUCY2C	2,984	PubTator's text mining	https://conductscience.org/library/genes/2984

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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