Paper · 9435295

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.

Xu X and 7 others. Development, 1998. Cited by 462 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Papers, record 9435295. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9435295

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.; PubMed
Journal: Development; PubMed
Year: 1998; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/9435295/; PubMed
DOI: https://doi.org/10.1242/dev.125.4.753; PubMed
The journal: https://conductscience.org/library/journal-index/8701744; PubMed
Citations, by iCite: 462; iCite
Relative citation ratio, by iCite: 8.64; iCite
Revised in PubMed: 2022-03-18; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Xu X	X
2	Weinstein M	M
3	Li C	C
4	Naski M	M
5	Cohen RI	R I
6	Ornitz DM	D M
7	Leder P	P
8	Deng C	C

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Extremities	Major topic
Fibroblast Growth Factors	Major topic
Growth Substances	Major topic
Receptor Protein-Tyrosine Kinases	Major topic
Receptors, Fibroblast Growth Factor	Major topic
Animals
Base Sequence
DNA Primers
Ear, Inner
Embryonic Induction
Female
Fibroblast Growth Factor 10
Fibroblast Growth Factor 8
Gene Expression Regulation, Developmental
Male
Mice
Mice, Knockout
Mutation
Phenotype
Placentation
Polymerase Chain Reaction
Pregnancy
Receptor, Fibroblast Growth Factor, Type 2
Sequence Deletion
Signal Transduction

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
CA60673	NCI NIH HHS	United States	R01CA060673	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by188

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 462 citations.

PMID	Title	Journal	Year	In Papers	Source
42,647,227	Frameshift Mutations in Exon 1 of Fgf10 Frequently Yield Morphologically Normal Embryos.	J Dev Biol	2026	https://conductscience.org/library/papers/42647227	PubMed
42,633,326	Advances in FGF/FGFR Signaling: Implications for Disease and Therapy.	MedComm (2020)	2026	https://conductscience.org/library/papers/42633326	PubMed
42,429,045	FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review).	Int J Mol Med	2026	https://conductscience.org/library/papers/42429045	PubMed
42,281,473	Developmental and transcriptional programs that define the initiation of the forelimb.	Development	2026	https://conductscience.org/library/papers/42281473	PubMed
41,981,936	Ectopic Expression of T-Box Transcription Factors Alters Mouse Forelimb Formation.	Genesis	2026	https://conductscience.org/library/papers/41981936	PubMed
41,823,500	Genetic Regulation of Wnt/PCP Components Through Fgf10/Fgfr2/Sox9 Module in Tear Duct Development.	Invest Ophthalmol Vis Sci	2026	https://conductscience.org/library/papers/41823500	PubMed
41,394,637	Developmental and transcriptional programs that define the initiation of the forelimb.	bioRxiv	2025	https://conductscience.org/library/papers/41394637	PubMed
40,972,968	Genetic knockout suggests Isl1 enhancer redundancy in mouse hindlimb development.	Dev Biol	2025	https://conductscience.org/library/papers/40972968	PubMed
40,454,573	Feto-placental blood vessel development.	Development	2025	https://conductscience.org/library/papers/40454573	PubMed
40,257,501	Increased thermal stability of FGF10 leads to ectopic signaling during development.	Cell Mol Life Sci	2025	https://conductscience.org/library/papers/40257501	PubMed

1 to 10 of 188

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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