Paper9799232
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.
Häcker H and 8 others. EMBO J, 1998. Cited by 480 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Download JSON
Cite this record
ConductScience Library. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Papers, record 9799232. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9799232
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.
- PubMed
Topics24
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Antigen-Presenting Cells | Major topic |
| Calcium-Calmodulin-Dependent Protein Kinases | Major topic |
| DNA Methylation | Major topic |
| DNA, Bacterial | Major topic |
| Endocytosis | Major topic |
| Endosomes | Major topic |
| Macrophages | Major topic |
| Mitogen-Activated Protein Kinases | Major topic |
| Activating Transcription Factor 2 | |
| Animals | |
| Cell Line | |
| Chloroquine | |
| Cyclic AMP Response Element-Binding Protein | |
| Cytokines | |
| Enzyme Activation | |
| JNK Mitogen-Activated Protein Kinases | |
| Mice | |
| Oligoribonucleotides | |
| Phosphorylation | |
| Signal Transduction | |
| Transcription Factor AP-1 | |
| Transcription Factors | |
| Transcriptional Activation | |
| p38 Mitogen-Activated Protein Kinases |
Source PubMed
References69
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 7,583,362 | Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. | J Inflamm | 1995 | https://conductscience.org/library/papers/7583362 | PubMed |
| 2 | 8,610,116 | Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. | Proc Natl Acad Sci U S A | 1996 | https://conductscience.org/library/papers/8610116 | PubMed |
| 3 | 8,622,669 | MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. | Mol Cell Biol | 1996 | https://conductscience.org/library/papers/8622669 | PubMed |
| 4 | 8,617,238 | The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. | EMBO J | 1996 | https://conductscience.org/library/papers/8617238 | PubMed |
| 5 | 8,662,521 | Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. | Science | 1996 | https://conductscience.org/library/papers/8662521 | PubMed |
| 6 | 1,890,302 | Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. | J Immunol | 1991 | https://conductscience.org/library/papers/1890302 | PubMed |
| 7 | 1,832,676 | Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. | J Biol Chem | 1991 | https://conductscience.org/library/papers/1832676 | PubMed |
| 8 | 1,922,387 | Phosphorylation of c-jun mediated by MAP kinases. | Nature | 1991 | https://conductscience.org/library/papers/1922387 | PubMed |
| 9 | 9,582,275 | Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. | EMBO J | 1998 | https://conductscience.org/library/papers/9582275 | PubMed |
| 10 | 9,645,386 | Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. | Eur J Immunol | 1998 | https://conductscience.org/library/papers/9645386 | PubMed |
| 11 | 7,287,819 | Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances. | J Cell Biol | 1981 | https://conductscience.org/library/papers/7287819 | PubMed |
| 12 | 3,856,070 | Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors. | J Natl Cancer Inst | 1985 | https://conductscience.org/library/papers/3856070 | PubMed |
| 13 | 2,423,876 | CpG-rich islands and the function of DNA methylation. | Nature | 1986 | https://conductscience.org/library/papers/2423876 | PubMed |
| 14 | 1,749,429 | Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. | Nature | 1991 | https://conductscience.org/library/papers/1749429 | PubMed |
| 15 | 1,732,418 | An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion. | J Exp Med | 1992 | https://conductscience.org/library/papers/1732418 | PubMed |
| 16 | 1,376,349 | Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. | J Immunol | 1992 | https://conductscience.org/library/papers/1376349 | PubMed |
| 17 | 1,630,458 | Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. | Mol Cell Biol | 1992 | https://conductscience.org/library/papers/1630458 | PubMed |
| 18 | 1,460,426 | Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. | J Exp Med | 1992 | https://conductscience.org/library/papers/1460426 | PubMed |
| 19 | 8,512,586 | Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1. | Biochem Pharmacol | 1993 | https://conductscience.org/library/papers/8512586 | PubMed |
| 20 | 8,224,842 | Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. | Genes Dev | 1993 | https://conductscience.org/library/papers/8224842 | PubMed |
Cited by167
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 480 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,931,433 | Targeting Porcine Macrophages: The Role of Immune Modulators Against African Swine Fever Virus. | Vaccines (Basel) | 2026 | https://conductscience.org/library/papers/42931433 | PubMed |
| 41,868,146 | Key role of TLR3 in type I IFN expression and apoptosis induction in IBDV-infected chicken fibroblast cells. | Front Cell Infect Microbiol | 2026 | https://conductscience.org/library/papers/41868146 | PubMed |
| 39,479,800 | Loss of STIM1 and STIM2 in Salivary Glands Disrupts ANO1 Function but Does Not Induce Sjogren's Disease. | Function (Oxf) | 2025 | https://conductscience.org/library/papers/39479800 | PubMed |
| 38,764,493 | The Recombinant Profilin from Free-Living Amoebae Induced Allergic Immune Responses via TLR2. | J Inflamm Res | 2024 | https://conductscience.org/library/papers/38764493 | PubMed |
| 37,655,977 | Staphylococcus aureus planktonic but not biofilm environment induces an IFN-β macrophage immune response via the STING/IRF3 pathway. | Virulence | 2023 | https://conductscience.org/library/papers/37655977 | PubMed |
| 35,302,362 | Delivery Order of Nanoconstructs Affects Intracellular Trafficking by Endosomes. | J Am Chem Soc | 2022 | https://conductscience.org/library/papers/35302362 | PubMed |
| 34,816,630 | Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury. | Adv Sci (Weinh) | 2022 | https://conductscience.org/library/papers/34816630 | PubMed |
| 33,693,723 | What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology. | J Mol Cell Biol | 2021 | https://conductscience.org/library/papers/33693723 | PubMed |
| 33,597,952 | Cell Surface Expression of Endosomal Toll-Like Receptors-A Necessity or a Superfluous Duplication? | Front Immunol | 2020 | https://conductscience.org/library/papers/33597952 | PubMed |
| 33,526,007 | Insights of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) pandemic: a current review. | Biol Proced Online | 2021 | https://conductscience.org/library/papers/33526007 | PubMed |
| 33,447,984 | Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implications. | Environ Sci Pollut Res Int | 2021 | https://conductscience.org/library/papers/33447984 | PubMed |
| 33,428,995 | Nanocarrier vaccines for SARS-CoV-2. | Adv Drug Deliv Rev | 2021 | https://conductscience.org/library/papers/33428995 | PubMed |
| 33,137,649 | Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19. | Cell Immunol | 2020 | https://conductscience.org/library/papers/33137649 | PubMed |
| 33,123,014 | Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines. | Front Pharmacol | 2020 | https://conductscience.org/library/papers/33123014 | PubMed |
| 32,902,942 | Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation. | J Cardiovasc Pharmacol | 2020 | https://conductscience.org/library/papers/32902942 | PubMed |
| 32,787,186 | Endosomal Organization of CpG Constructs Correlates with Enhanced Immune Activation. | Nano Lett | 2020 | https://conductscience.org/library/papers/32787186 | PubMed |
| 32,715,647 | Hydroxychloroquine in rheumatic autoimmune disorders and beyond. | EMBO Mol Med | 2020 | https://conductscience.org/library/papers/32715647 | PubMed |
| 32,714,335 | Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine. | Front Immunol | 2020 | https://conductscience.org/library/papers/32714335 | PubMed |
| 32,708,112 | COVID-19: A Review on Diagnosis, Treatment, and Prophylaxis. | Int J Mol Sci | 2020 | https://conductscience.org/library/papers/32708112 | PubMed |
| 32,674,481 | Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy. | Int J Mol Sci | 2020 | https://conductscience.org/library/papers/32674481 | PubMed |
Genes5
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ATF2 | 1,386 | PubTator's text mining | https://conductscience.org/library/genes/1386 | NCBI Gene |
| IL6 | 3,569 | PubTator's text mining | https://conductscience.org/library/genes/3569 | NCBI Gene |
| JUN | 3,725 | PubTator's text mining | https://conductscience.org/library/genes/3725 | NCBI Gene |
| MAP2K4 | 6,416 | PubTator's text mining | https://conductscience.org/library/genes/6416 | NCBI Gene |
| TNF | 7,124 | PubTator's text mining | https://conductscience.org/library/genes/7124 | NCBI Gene |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this paper from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/papers/v1/9799232
GET https://conductscience.org/api/papers/v1/9799232/references?page=2