Trial · NCT04026555
Realtime Streaming Clinical Use Engine for Medical Escalation
NCT04026555, Not applicable, Completed, Icahn School of Medicine at Mount Sinai; results first posted 2025-01-14
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Realtime Streaming Clinical Use Engine for Medical Escalation. Trials, record NCT04026555. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04026555
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Realtime Streaming Clinical Use Engine for Medical Escalation
- NCT number
- NCT04026555
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 2,780 participants, actual
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Conditions
- Clinical Deterioration, Hospital Medicine, Monitoring, Physiologic
- Interventions
- MEWS++ Monitoring, Predictor Score
- First posted
- 2019-07-19
- Last updated
- 2025-01-14
- Results first posted
- 2025-01-14
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Overall Rate of Escalation | 10 months | Rate of escalation of care from floor to Stepdown, Telemetry, ICU, per 1,000 patient bed days. |
| Secondary | Number of Participants Requiring Blood Pressure Support | 10 months | Number of participants requiring blood pressure support agents such as initiation of vasopressor medication or administration of fluid bolus. |
| Secondary | Number of Participants Requiring Respiratory Support | 10 months | Number of participants requiring respiratory support intervention such as initiation of nasal cannula to high flow or frequency of intubation. |
| Secondary | Number of Participants Who Experienced a Cardiac Arrest Episode | 10 months | The number of patients who had a cardiac arrest. |
| Secondary | Mortality Rate | Duration of hospital stay, until discharge, regardless of stay length for patients who died in hospital, or 30 days after admission, starting from date of admission, up to 6 weeks. | Number of Mortalities - Combined In-hospital and 30-day mortality. Mortalities only counted once. 30-day mortality includes those patients who died in-hospital within 30 days. |
| Secondary | Notification Frequency - Number of Alerts Sent Per Day to Providers | 10 months | The number is calculated as average number of alerts sent per day over all the days in the study period. |
| Secondary | Number of Calls | 10 months | The average number of calls to RRT made per patient, regardless of alert. Not evaluated. |
| Secondary | Sensitivity and Specificity of the RRT Alert | 10 months | The performance of the alert will be evaluated by calculating the sensitivity, specificity, positive predictive value, negative predictive value, precision, recall, and F1-score. This will be done both for the overall escalation rate and if possible for individual escalations (ICU, step-down, telemetry) and death. |
Source ClinicalTrials.gov
Outcomes10
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Overall Rate of Escalation | 10 months | escalations per 1,000 patient bed days | NUMBER | |
| SECONDARY | Number of Participants Requiring Blood Pressure Support | 10 months | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Requiring Respiratory Support | 10 months | No statistical comparison performed due to low rate of events. | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Number of Participants Who Experienced a Cardiac Arrest Episode | 10 months | No statistical comparison performed due to no events. | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Mortality Rate | Duration of hospital stay, until discharge, regardless of stay length for patients who died in hospital, or 30 days after admission, starting from date of admission, up to 6 weeks. | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Notification Frequency - Number of Alerts Sent Per Day to Providers | 10 months | No statistical analysis performed | alerts per day | MEAN |
| SECONDARY | Number of Calls | 10 months | Data were not collected for this outcome measure. | ||
| SECONDARY | Sensitivity and Specificity of the RRT Alert | 10 months | Patients in the intervention arm. | proportion | NUMBER |
| POST_HOC | Time to ICU Escalation | From time of alert until transfer to an ICU, assessed up to discharge from the hospital or death | hours | MEDIAN | |
| POST_HOC | Likelihood of Earlier Hospital Discharge | Duration of hospital stay, starting from admission, up to the day of discharge, regardless of the length of hospital stay, up to 1 year. | Patients who survived to hospital discharge | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group28
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Overall Rate of Escalation | Intervention - Alert Sent | 12.3 | escalations per 1,000 patient bed days | ||
| Overall Rate of Escalation | Control - Standard of Care Monitoring | 11.3 | escalations per 1,000 patient bed days | ||
| Number of Participants Requiring Blood Pressure Support | Intervention - Alert Sent | 239 | Participants | ||
| Number of Participants Requiring Blood Pressure Support | Control - No Alert Sent | 142 | Participants | ||
| Number of Participants Requiring Respiratory Support | Intervention - Alert Sent | 15 | Participants | ||
| Number of Participants Requiring Respiratory Support | Control - No Alert Sent | 5 | Participants | ||
| Number of Participants Who Experienced a Cardiac Arrest Episode | Intervention - Alert Sent | 0 | Participants | ||
| Number of Participants Who Experienced a Cardiac Arrest Episode | Control - No Alert Sent | 0 | Participants | ||
| Mortality Rate | Intervention - Alert Sent | Combined in-hospital and 30-day | 104 | Participants | |
| Mortality Rate | Control - No Alert Sent | Combined in-hospital and 30-day | 117 | Participants |
1 to 10 of 28Source ClinicalTrials.gov
See all 28 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | MEWS++ Monitoring | 1,506 | |
| Overall Study | STARTED | Standard of Care Monitoring | 1,274 | |
| Overall Study | COMPLETED | MEWS++ Monitoring | 1,506 | |
| Overall Study | COMPLETED | Standard of Care Monitoring | 1,274 | |
| Overall Study | NOT COMPLETED | MEWS++ Monitoring | 0 | |
| Overall Study | NOT COMPLETED | Standard of Care Monitoring | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | MEWS++ Monitoring | 104 | 1,488 |
| Total, all-cause mortality | Standard of Care Monitoring | 117 | 1,252 |
| Total, other adverse events | MEWS++ Monitoring | 0 | 0 |
| Total, other adverse events | Standard of Care Monitoring | 0 | 0 |
| Total, serious adverse events | MEWS++ Monitoring | 0 | 0 |
| Total, serious adverse events | Standard of Care Monitoring | 0 | 0 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38380992 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons4
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Intervention - Alert Sent vs Control - No Alert Sent: Number of Participants Requiring Respiratory Support | Trial comparisons |
| Intervention - Alert Sent vs Control - No Alert Sent: Number of Participants Requiring Blood Pressure Support | Trial comparisons |
| MEWS++ Monitoring vs Standard of Care Monitoring: deaths from any cause | Trial comparisons |
| Intervention - Alert Sent vs Control - No Alert Sent: Number of Participants Who Experienced a Cardiac Arrest Episode | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04026555
GET https://conductscience.org/api/trials/v1/NCT04026555/results?page=2