ConductScience.org, home

85,013 comparisons from ClinicalTrials.gov. Counted 2026-11-10.

85,013 comparisons

Most participants first33,758 with no events in either group come last1,301 to 1,320 of 85,013

Show the results as
ComparisonWith the outcomeRisk difference, 95% intervalParticipantsTrial
Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Wound Infection321 of 3,483

311 of 3,509

0.4 points

-1.0 to 1.7

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Stroke26 of 3,483

19 of 3,509

0.2 points

-0.2 to 0.6

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Cardiac Arrest15 of 3,483

19 of 3,509

-0.1 points

-0.5 to 0.2

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Myocardial Infarction (MI)215 of 3,483

219 of 3,509

-0.1 points

-1.2 to 1.1

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O vs Nitrous Oxide Free: deaths from any cause42 of 3,483

57 of 3,509

-0.4 points

-1.0 to 0.1

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.283 of 3,483

296 of 3,509

-0.3 points

-1.6 to 1.0

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Nitrous Oxide: 70% N2O vs Nitrous Oxide Free: serious adverse events283 of 3,483

296 of 3,509

-0.3 points

-1.6 to 1.0

6,992NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

TYRX Envelope vs Control: deaths from any cause349 of 3,495

365 of 3,488

-0.5 points

-1.9 to 0.9

6,983NCT02277990

World-wide Randomized Antibiotic Envelope Infection Prevention Trial

TYRX Envelope vs Control: serious adverse events1,553 of 3,495

1,548 of 3,488

0.1 points

-2.3 to 2.4

6,983NCT02277990

World-wide Randomized Antibiotic Envelope Infection Prevention Trial

Intensive Glycemic Control vs Standard Glycemic Control: Number of Participants With > 2 cm of Height Loss678 of 3,482

686 of 3,497

-0.1 points

-2.0 to 1.7

6,979NCT00324350

Intensive Glycemic Control and Skeletal Health Study

Linagliptin vs Placebo: deaths from any cause250 of 3,494

253 of 3,485

-0.1 points

-1.3 to 1.1

6,979NCT01897532

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Linagliptin vs Placebo: serious adverse events1,293 of 3,494

1,343 of 3,485

-1.5 points

-3.8 to 0.7

6,979NCT01897532

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Nesiritide vs Placebo: Composite of Persistent or Worsening Heart Failure and All-Cause Mortality147 of 3,459

165 of 3,462

-0.5 points

-1.5 to 0.5

6,921NCT00475852

A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure

VAX-MOM COVID-19 Intervention vs Standard of Care: Rate of COVID-19 Vaccination (9 Month)404 of 4,256

180 of 2,655

2.7 points

1.4 to 4.0

6,911NCT05570630

VAX-MOM COVID-19: Increasing Maternal COVID-19 Vaccination

Pregnant Women vs Post-partum Women: Number of Participants With Symptoms of Anxiety and Depression1,200 of 5,712

438 of 1,182

-16.0 points

-19.0 to -13.1

6,894NCT04385238

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Pregnant Women vs Post-partum Women: Number of Participants With Symptoms of Post-traumatic Stress Disorder1,028 of 5,712

532 of 1,182

-27.0 points

-30.0 to -24.0

6,894NCT04385238

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Chronic HF Without SDB vs Chronic HF With SDB: NYHA Class ≥III2,566 of 3,686

2,341 of 3,190

-3.8 points

-5.9 to -1.6

6,876NCT01500759

Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

Patients With Chronic HF Without SDB and NYHA>III vs Patients With Chronic Heart Failure and SDB and NYHA >III: NYHA Class >= III as Predictor for SDB in Chronic HF2,566 of 3,686

2,341 of 3,190

-3.8 points

-5.9 to -1.6

6,876NCT01500759

Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

Chronic HF Without SDB vs Chronic HF With SDB: Ischemic Etiology1,961 of 3,686

1,742 of 3,190

-1.4 points

-3.8 to 1.0

6,876NCT01500759

Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

Chronic HF Without SDB vs Chronic HF With SDB: Digitalis717 of 3,686

599 of 3,190

0.7 points

-1.2 to 2.5

6,876NCT01500759

Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

Request

GET /api/comparisons/v1

Words from a trial's title, conditions or interventions, its outcome or its groups, or an NCT number.

An outcome counted in participants, the serious adverse events, or the deaths from any cause.

No key needed

Response

The first 2 of this page's 20 results. GET /api/comparisons/v1?page=66

{
  "data": {
    "total": 85013,
    "results": [
      {
        "id": "NCT00430989-4e5a6a64",
        "title": "Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Wound Infection",
        "summary": "321 of 3483 against 311 of 3509; risk difference 0.4 points, 95% interval -1.0 to 1.7; NCT00430989, The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial",
        "record": "/library/comparisons/NCT00430989-4e5a6a64",
        "nct_id": "NCT00430989",
        "kind": "outcome",
        "participants": 6992,
        "risk_difference": {
          "value": 0.0035326902717731645,
          "lower": -0.009926302647681582,
          "upper": 0.017004427888073555
        },
        "group_1": "321 of 3,483",
        "group_2": "311 of 3,509",
        "difference": "0.4 points",
        "interval": "-1.0 to 1.7",
        "trial_title": "The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial"
      },
      {
        "id": "NCT00430989-70eb35f8",
        "title": "Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Stroke",
        "summary": "26 of 3483 against 19 of 3509; risk difference 0.2 points, 95% interval -0.2 to 0.6; NCT00430989, The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial",
        "record": "/library/comparisons/NCT00430989-70eb35f8",
        "nct_id": "NCT00430989",
        "kind": "outcome",
        "participants": 6992,
        "risk_difference": {
          "value": 0.0020501811223786384,
          "lower": -0.0017915723160902338,
          "upper": 0.006011527551370957
        },
        "group_1": "26 of 3,483",
        "group_2": "19 of 3,509",
        "difference": "0.2 points",
        "interval": "-0.2 to 0.6",
        "trial_title": "The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial"
      }
    ],
    "no_events": 33758,
    "columns": [
      {
        "key": "title",
        "label": "Comparison"
      },
      {
        "key": "group_1",
        "label": "With the outcome",
        "under": "group_2"
      },
      {
        "key": "difference",
        "label": "Risk difference, 95% interval",
        "under": "interval"
      },
      {
        "key": "participants",
        "label": "Participants"
      },
      {
        "key": "nct_id",
        "label": "Trial",
        "under": "trial_title"
      }
    ],
    "order": "Most participants first",
    "kinds": {
      "all": 85013,
      "outcome": 33568,
      "serious-adverse-events": 31897,
      "deaths": 19548
    }
  },
  "release": "trial-comparisons-2026-03-23-0.1.0",
  "terms": [
    {
      "source": "ClinicalTrials.gov's posted results, through CTTI's AACT",
      "license": "ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "Freely available. Acknowledgement requested"
    },
    {
      "source": "ClinicalTrials.gov",
      "license": "none stated",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "None stated"
    }
  ],
  "next": "/api/comparisons/v1?page=67",
  "request_id": "LoDU7RO8OEnnhLuR"
}
trial-comparisons-2026-03-23-0.1.0Next page

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

Genes

NCBI Gene

One gene with its proteins, patents, drugs, trials, grants and papers.

Open193,990 genes2026-11-11

Trials

ClinicalTrials.gov

Search clinical trials by condition, drug, outcome or NCT number, with the results each one posted.

Open611,552 trials2026-11-12

Sequences

Patent publications

Paste a sequence and see the patents that disclose it.

For invited accounts.

Opens sequences.conductscience.org

By invitation39,249,078 sequences2026-11-05

For software

Read Trial comparisons from software.

Every answer on this page is also JSON, under /api/comparisons/v1. No key.

GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome

Ask an assistant

  • In FOURIER, how did serious adverse events compare between evolocumab and placebo?
  • Which metformin trials reported deaths, and what was the risk difference?
  • What was the number needed to treat for HELIOS-B's composite outcome?
  • Which placebo-controlled heart failure trials had the most participants?