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85,013 comparisons from ClinicalTrials.gov. Counted 2026-11-10.
Most participants first33,758 with no events in either group come last1,301 to 1,320 of 85,013
| Comparison | With the outcome | Risk difference, 95% interval | Participants | Trial |
|---|---|---|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Wound Infection | 321 of 3,483 311 of 3,509 | 0.4 points -1.0 to 1.7 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Stroke | 26 of 3,483 19 of 3,509 | 0.2 points -0.2 to 0.6 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Cardiac Arrest | 15 of 3,483 19 of 3,509 | -0.1 points -0.5 to 0.2 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Myocardial Infarction (MI) | 215 of 3,483 219 of 3,509 | -0.1 points -1.2 to 1.1 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O vs Nitrous Oxide Free: deaths from any cause | 42 of 3,483 57 of 3,509 | -0.4 points -1.0 to 0.1 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery. | 283 of 3,483 296 of 3,509 | -0.3 points -1.6 to 1.0 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| Nitrous Oxide: 70% N2O vs Nitrous Oxide Free: serious adverse events | 283 of 3,483 296 of 3,509 | -0.3 points -1.6 to 1.0 | 6,992 | NCT00430989 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial |
| TYRX Envelope vs Control: deaths from any cause | 349 of 3,495 365 of 3,488 | -0.5 points -1.9 to 0.9 | 6,983 | NCT02277990 World-wide Randomized Antibiotic Envelope Infection Prevention Trial |
| TYRX Envelope vs Control: serious adverse events | 1,553 of 3,495 1,548 of 3,488 | 0.1 points -2.3 to 2.4 | 6,983 | NCT02277990 World-wide Randomized Antibiotic Envelope Infection Prevention Trial |
| Intensive Glycemic Control vs Standard Glycemic Control: Number of Participants With > 2 cm of Height Loss | 678 of 3,482 686 of 3,497 | -0.1 points -2.0 to 1.7 | 6,979 | NCT00324350 Intensive Glycemic Control and Skeletal Health Study |
| Linagliptin vs Placebo: deaths from any cause | 250 of 3,494 253 of 3,485 | -0.1 points -1.3 to 1.1 | 6,979 | NCT01897532 Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) |
| Linagliptin vs Placebo: serious adverse events | 1,293 of 3,494 1,343 of 3,485 | -1.5 points -3.8 to 0.7 | 6,979 | NCT01897532 Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) |
| Nesiritide vs Placebo: Composite of Persistent or Worsening Heart Failure and All-Cause Mortality | 147 of 3,459 165 of 3,462 | -0.5 points -1.5 to 0.5 | 6,921 | NCT00475852 A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure |
| VAX-MOM COVID-19 Intervention vs Standard of Care: Rate of COVID-19 Vaccination (9 Month) | 404 of 4,256 180 of 2,655 | 2.7 points 1.4 to 4.0 | 6,911 | NCT05570630 VAX-MOM COVID-19: Increasing Maternal COVID-19 Vaccination |
| Pregnant Women vs Post-partum Women: Number of Participants With Symptoms of Anxiety and Depression | 1,200 of 5,712 438 of 1,182 | -16.0 points -19.0 to -13.1 | 6,894 | NCT04385238 Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic |
| Pregnant Women vs Post-partum Women: Number of Participants With Symptoms of Post-traumatic Stress Disorder | 1,028 of 5,712 532 of 1,182 | -27.0 points -30.0 to -24.0 | 6,894 | NCT04385238 Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic |
| Chronic HF Without SDB vs Chronic HF With SDB: NYHA Class ≥III | 2,566 of 3,686 2,341 of 3,190 | -3.8 points -5.9 to -1.6 | 6,876 | NCT01500759 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry |
| Patients With Chronic HF Without SDB and NYHA>III vs Patients With Chronic Heart Failure and SDB and NYHA >III: NYHA Class >= III as Predictor for SDB in Chronic HF | 2,566 of 3,686 2,341 of 3,190 | -3.8 points -5.9 to -1.6 | 6,876 | NCT01500759 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry |
| Chronic HF Without SDB vs Chronic HF With SDB: Ischemic Etiology | 1,961 of 3,686 1,742 of 3,190 | -1.4 points -3.8 to 1.0 | 6,876 | NCT01500759 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry |
| Chronic HF Without SDB vs Chronic HF With SDB: Digitalis | 717 of 3,686 599 of 3,190 | 0.7 points -1.2 to 2.5 | 6,876 | NCT01500759 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry |
Response
The first 2 of this page's 20 results. GET /api/comparisons/v1?page=66
{
"data": {
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{
"id": "NCT00430989-4e5a6a64",
"title": "Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Wound Infection",
"summary": "321 of 3483 against 311 of 3509; risk difference 0.4 points, 95% interval -1.0 to 1.7; NCT00430989, The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial",
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"trial_title": "The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial"
},
{
"id": "NCT00430989-70eb35f8",
"title": "Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Stroke",
"summary": "26 of 3483 against 19 of 3509; risk difference 0.2 points, 95% interval -0.2 to 0.6; NCT00430989, The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial",
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"release": "trial-comparisons-2026-03-23-0.1.0",
"terms": [
{
"source": "ClinicalTrials.gov's posted results, through CTTI's AACT",
"license": "ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299",
"notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
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}ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
NCBI Gene
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Every answer on this page is also JSON, under /api/comparisons/v1. No key.
GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome
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