Disease · MONDO_0003878

malignant choroid melanoma

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. malignant choroid melanoma. Diseases, record MONDO_0003878. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0003878

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: malignant choroid melanoma; Open Targets
Open Targets ID: MONDO_0003878; Open Targets
Other names: choroid malignant melanoma, choroid melanoma, choroidal melanoma, malignant melanoma of choroid, malignant melanoma of the choroid, melanoma (disease) of optic choroid, melanoma of choroid, melanoma of the choroid, optic choroid melanoma, optic choroid melanoma (disease); Open Targets
Disease Ontology: DOID:6438; Disease Ontology
NCI Thesaurus: C4561; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 2 of its 2 drugs, from ClinicalTrials.gov; Open Targets

Drugs2

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
RANIBIZUMAB	CHEMBL1201825	Antibody	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
BELZUPACAP SAROTALOCAN	CHEMBL4802193	Protein	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets

Targets1

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes
VEGFA	Vascular endothelial growth factor A, long form	1	Vascular endothelial growth factor A inhibitor	Phase 3	https://conductscience.org/library/genes/7422

Source Drugs and targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03052127	Study in Subjects With Small Primary Choroidal Melanoma	Phase 1/2	57	2024-02-01	Uveal Melanoma, Ocular Melanoma, Choroidal Melanoma	BELZUPACAP SAROTALOCAN	Its record names the disease	ClinicalTrials.gov
NCT00680225	Lucentis as an Adjuvant Therapy With TTT-ICG Based in Choroidal Melanoma	Phase 3	10	2017-04-12	Choroidal Melanoma	RANIBIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT01251978	Ranibizumab as Adjuvant Therapy for the Treatment of Choroidal Melanoma (Cohort 2)	Phase 2	10	2016-10-19	Choroidal Melanoma	RANIBIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT06007690	A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma	Phase 3	108		Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma	BELZUPACAP SAROTALOCAN	Its record names the disease	ClinicalTrials.gov
NCT00765921	Ranibizumab in Combination With Proton Beam Irradiation for Choroidal Melanoma	Phase 1	40		Choroidal Melanoma	RANIBIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT04417530	Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma	Phase 2	22		Uveal Melanoma, Ocular Melanoma, Choroidal Melanoma	BELZUPACAP SAROTALOCAN	Its record names the disease	ClinicalTrials.gov
NCT00750399	Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma	Phase 1	10		Radiation Retinopathy, Choroidal Melanoma	RANIBIZUMAB	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
20142553	RESULT	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0003878

GET https://conductscience.org/api/diseases/v1/MONDO_0003878/drugs

API reference For AI assistants