Disease · MONDO_0008608
Trials20
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
1 to 20 of 20
Download this page as JSON| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01576705 | Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children | Phase 3 | 175 | 2020-05-13 | Down Syndrome | FOLINIC ACID, LEVOTHYROXINE | Its record names the disease | ClinicalTrials.gov |
| NCT02304302 | Down Syndrome Memantine Follow-up Study | Phase 2 | 160 | 2022-04-05 | Down Syndrome, Intellectual Disability | MEMANTINE HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov |
| NCT01084135 | Rivastigmine Study in Adolescents With Down Syndrome | Phase 1/2 | 42 | 2015-03-12 | Down Syndrome | RIVASTIGMINE | Its record names the disease | ClinicalTrials.gov |
| NCT01791725 | A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia | Phase 2 | 23 | 2016-01-29 | Down Syndrome | SCYLLITOL | Its record names the disease | ClinicalTrials.gov |
| NCT02432716 | Investigation of the Safety of Intranasal Glulisine in Down Syndrome | Phase 1 | 12 | 2019-12-06 | Down Syndrome | INSULIN GLULISINE | Its record names the disease | ClinicalTrials.gov |
| NCT02024789 | A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) | Phase 2 | 173 | Down Syndrome | BASMISANIL | Its record names the disease | ClinicalTrials.gov | |
| NCT06206824 | Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease | Phase 1 | 152 | Healthy Volunteers, Down Syndrome, Alzheimer's Disease | 5-(6-BENZOTHIAZOLYLMETHYLENE)-3,5-DIHYDRO-2-(((1S)-1-(METHOXYMETHYL)-3-METHYLBUTYL)AMINO)-4H-IMIDAZOL-4-ONE, (5Z)- | Its record names the disease | ClinicalTrials.gov | |
| NCT00294593 | Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome | Phase 2/3 | 120 | Down Syndrome | LEUCOVORIN | Its record names the disease | ClinicalTrials.gov | |
| NCT07232134 | The Efficacy of Therapy in Patients With Acute Myeloid Leukemia and Down Syndrome in Russia | Phase 3 | 100 | AML (Acute Myelogenous Leukemia), Down Syndrome (DS) | CYTARABINE, DAUNORUBICIN, ETOPOSIDE, IDARUBICIN | Its record names the disease | ClinicalTrials.gov | |
| NCT07598643 | Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1 | Phase 2 | 92 | Down Syndrome | TOFACITINIB | Its record names the disease | ClinicalTrials.gov | |
| NCT06465823 | Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome | Phase 2 | 64 | Down Syndrome | BUMETANIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT03783338 | Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome | Not applicable | 59 | Children With Down Syndrome | CHOLECALCIFEROL | Its record names the disease | ClinicalTrials.gov | |
| NCT04390646 | GnRH Therapy on Cognition in Down Syndrome | Phase 2/3 | 56 | Down Syndrome, Cognitive Decline, Alzheimer Disease, Early Onset, Olfaction Disorders | GONADORELIN ACETATE | Its record names the disease | ClinicalTrials.gov | |
| NCT02484703 | A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age | Phase 2 | 45 | Down Syndrome | BASMISANIL | Its record names the disease | ClinicalTrials.gov | |
| NCT02094053 | A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. | Phase 2 | 36 | Down Syndrome | DONEPEZIL HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT01436955 | A Study of RG1662 in Individuals With Down Syndrome | Phase 1 | 35 | Down Syndrome | BASMISANIL | Its record names the disease | ClinicalTrials.gov | |
| NCT07531940 | Escalating Doses of Memantine in Down Syndrome (MEDS-123) | Phase 1 | 25 | Down Syndrome, Intellectual Disability, Alzheimer Dementia (AD) | MEMANTINE | Its record names the disease | ClinicalTrials.gov | |
| NCT00748007 | Efficacy of Rivastigmine in Patients With Down Syndrome | Not applicable | 14 | Down Syndrome | RIVASTIGMINE | Its record names the disease | ClinicalTrials.gov | |
| NCT05482334 | Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome | Phase 2 | 0 | Down Syndrome | SARGRAMOSTIM | Its record names the disease | ClinicalTrials.gov | |
| NCT00378456 | Vitamins and Minerals for Children With Downs Syndrome | Not applicable | Trisiomy 21 (Down Syndrome) | FOLINIC ACID | Its record names the disease | ClinicalTrials.gov |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
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GET https://conductscience.org/api/diseases/v1/MONDO_0008608/trials