Disease · MONDO_0008633
Muckle-Wells syndrome
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Muckle-Wells syndrome. Diseases, record MONDO_0008633. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0008633
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs3
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| CANAKINUMAB | CHEMBL1201834 | Antibody | Approval | DailyMed | 5 | 4 | 4 | Drugs and targets |
| RILONACEPT | CHEMBL1201830 | Protein | Approval | DailyMed | 3 | 2 | 2 | Drugs and targets |
| GEVOKIZUMAB | CHEMBL1743026 | Antibody | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets1
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes |
|---|---|---|---|---|---|
| IL1B | Interleukin-1 beta | 3 | Interleukin-1 beta inhibitor; Interleukin-1 beta negative allosteric modulator | Approval | https://conductscience.org/library/genes/3553 |
Source Drugs and targets
Trials7
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00685373 | Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease | Phase 3 | 166 | 2011-05-27 | Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease | CANAKINUMAB | Its record names the disease | ClinicalTrials.gov |
| NCT00465985 | Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome | Phase 3 | 35 | 2011-02-11 | Muckle Wells Syndrome | CANAKINUMAB | Its record names the disease | ClinicalTrials.gov |
| NCT00094900 | Interleukin-1 Trap to Treat Autoinflammatory Diseases | Phase 2 | 11 | 2013-07-10 | Inflammation, Familial Mediterranean Fever, Still's Disease, Adult-Onset | RILONACEPT | Its record names the disease | ClinicalTrials.gov |
| NCT00487708 | Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms | Phase 2 | 34 | NALP3 Mutation | CANAKINUMAB | Its record names the disease | ClinicalTrials.gov | |
| NCT00991146 | Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase | Phase 3 | 19 | Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease | CANAKINUMAB | Its record names the disease | ClinicalTrials.gov | |
| NCT01045772 | Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) | Phase 2 | 10 | Muckle-Wells Syndrome, Schnitzler Syndrome | RILONACEPT | Its record names the disease | ClinicalTrials.gov | |
| NCT01211977 | A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease | Phase 1/2 | 0 | Muckle Wells Syndrome, Autoinflammatory, Behcet's Disease | GEVOKIZUMAB | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| ACZ885 vs Placebo: Number of Participants Who Experienced a Disease Flare in Part II | 0 of 15 | 13 of 16 | 31 | NCT00465985 |
Source Trial comparisons
Papers from its trials7
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0008633
GET https://conductscience.org/api/diseases/v1/MONDO_0008633/drugs