Disease · MONDO_0018872
acute megakaryoblastic leukemia
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. acute megakaryoblastic leukemia. Diseases, record MONDO_0018872. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0018872
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
AMKL, AML M7, FAB M7, acute M7 myeloid leukaemia, acute M7 myeloid leukemia, acute megakaryoblastic leukaemia, acute megakaryoblastic leukaemia (FAB type M7), acute megakaryoblastic leukaemia, FAB M7, acute megakaryoblastic leukemia (FAB type M7), acute megakaryoblastic leukemia, FAB M7, acute megakaryocytic leukaemia, acute megakaryocytic leukemia, acute megakaryocytic leukemias, acute myeloid leukaemia M7, acute myeloid leukemia M7, leukemia, megakaryocytic, malignant, megakaryocytic myelosis, thrombocytic leukaemia, thrombocytic leukemia
- Open Targets
Drugs1
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here |
|---|---|---|---|---|---|---|---|
| ALISERTIB | CHEMBL483158 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 |
Source Drugs and targets
Targets1
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes |
|---|---|---|---|---|---|
| AURKA | Aurora kinase A | 1 | Serine/threonine-protein kinase Aurora-A inhibitor | Unknown | https://conductscience.org/library/genes/6790 |
Source Drugs and targets
Trials1
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by |
|---|---|---|---|---|---|---|---|
| NCT02530619 | Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia | Not applicable | 26 | 2020-12-19 | Acute Megakaryoblastic Leukemia, Myelofibrosis, Primary Myelofibrosis | ALISERTIB | Its record names the disease |
Source ClinicalTrials.gov
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials0
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
None in this release.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0018872
GET https://conductscience.org/api/diseases/v1/MONDO_0018872/drugs