Drug · CHEMBL189
MILRINONE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. MILRINONE. Drugs and targets, record CHEMBL189. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL189
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| PDE3A | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | Phosphodiesterase 3A inhibitor | INHIBITOR | https://conductscience.org/library/genes/5139 |
Source ChEMBL
Diseases18
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| heart failure | Phase 1/2 | ClinicalTrials.gov | 6 | 6 | https://conductscience.org/library/drugs?q=MONDO_0005252 |
| pulmonary hypertension | Phase 3 | ClinicalTrials.gov | 6 | 6 | https://conductscience.org/library/drugs?q=MONDO_0005149 |
| acute kidney injury | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0002492 |
| acute myocardial infarction | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0004781 |
| aortic stenosis | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=EFO_0000266 |
| congenital diaphragmatic hernia | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005711 |
| congenital heart disease | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005453 |
| coronary artery disorder | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005010 |
| intracranial vasospasm | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0006812 |
| ischemia reperfusion injury | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005203 |
1 to 10 of 18Source Open Targets
See all 18 diseasesTrials51
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02726620 | Decision Support for Intraoperative Low Blood Pressure | 22,435 | 2019-05-16 | milrinone | Its name | ClinicalTrials.gov | |
| NCT00543309 | Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery | Phase 2 | 106 | 2018-06-25 | milrinone | Its name | ClinicalTrials.gov |
| NCT02951130 | Milrinone in Congenital Diaphragmatic Hernia | Phase 2 | 66 | 2025-11-06 | milrinone | Its name | ClinicalTrials.gov |
| NCT01088997 | Pharmacokinetic Study of Milrinone in Babies With Persistent Pulmonary Hypertension of the Newborn | 12 | 2016-07-12 | milrinone | Its name | ClinicalTrials.gov | |
| NCT02712788 | Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage | Phase 2 | 4 | 2019-07-02 | milrinone | Its name | ClinicalTrials.gov |
| NCT03823781 | Prophylactic Use of Milrinone After Congenital Heart Surgery in Infants | Phase 3 | 520 | milrinone | Its name | ClinicalTrials.gov | |
| NCT04362527 | Milrinone Infusion for VAsospam Treatment in Subarachnoid hemoRrhage | Phase 3 | 370 | milrinone | Its name | ClinicalTrials.gov | |
| NCT05267886 | CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock | Phase 4 | 346 | milrinone | Its name | ClinicalTrials.gov | |
| NCT06679855 | Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial | Phase 3 | 316 | milrinone | Its name | ClinicalTrials.gov | |
| NCT04282629 | Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia | Phase 2 | 234 | milrinone | Its name | ClinicalTrials.gov |
1 to 10 of 51
See all 51 trialsComparisons in its trials23
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Hypotension Decision Support vs Usual Care Group: deaths from any cause | 158 of 4,972 | 534 of 17,463 | 22,435 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: serious adverse events | 541 of 4,972 | 1,811 of 17,463 | 22,435 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 20 Minutes | 85 of 4,328 | 304 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Glycopyrrolate | 1,257 of 4,328 | 11,093 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Ephinephrine | 409 of 4,328 | 1,215 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 60 mmHg | 3,798 of 4,328 | 13,779 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 50 mmHg for > 10 Minutes | 326 of 4,328 | 1,159 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Usage Frequency of Cardiovascular Drugs: Phenylephrine | 3,685 of 4,328 | 12,211 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: In-hospital Mortality | 137 of 4,328 | 487 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
| Hypotension Decision Support vs Usual Care Group: Incidence of a MAP < 55 mmHg | 3,045 of 4,328 | 10,991 of 15,624 | 19,952 | NCT02726620 | Trial comparisons |
1 to 10 of 23
See all 23 comparisons in its trialsPapers from its trials44
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL189
GET https://conductscience.org/api/drugs/v1/CHEMBL189/trials?page=2