Drug · CHEMBL465

DRONABINOL

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. DRONABINOL. Drugs and targets, record CHEMBL465. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL465

On this page

Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: DRONABINOL; ChEMBL
ChEMBL ID: CHEMBL465; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Dronabinol component of ad-313, Dronabinol component of ad313, Dronabinol component of sci-110, Marinol, Syndros; ChEMBL
Other names: .delta.-9-tetrahydrocannabinol, .delta.1-thc, .delta.9-tetrahydrocannabinol, .delta.9-thc, ABBOTT 40566, ABBOTT-40566, Delta-9-tetrahydrocannabinol, Delta-9-thc, J882F, NSC-134454, QCD 84924, QCD-84924, SP 104, SP-104, Tetrahydrocannabinol, Tetrahydrocannabinols (-)-trans-.delta.9-form; ChEMBL
DrugBank: DB00470; DrugBank
InChIKey: CYQFCXCEBYINGO-IAGOWNOFSA-N; ChEMBL
Open Targets' highest stage: Approval, for 4 of its 98 diseases, from ATC and DailyMed; Open Targets

Targets1

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
CNR1	Cannabinoid receptor 1	Cannabinoid CB1 receptor agonist	AGONIST	https://conductscience.org/library/genes/1268

Source ChEMBL

Diseases98

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Phase 3	ClinicalTrials.gov	23	23	https://conductscience.org/library/drugs?q=HP_0012531
multiple sclerosis symptom measurement	Phase 3	ClinicalTrials.gov	12	12	https://conductscience.org/library/drugs?q=EFO_0803536
Chronic pain	Phase 2/3	ClinicalTrials.gov	10	10	https://conductscience.org/library/drugs?q=HP_0012532
post-traumatic stress disorder	Phase 2	ClinicalTrials.gov	8	8	https://conductscience.org/library/drugs?q=MONDO_0005146
cannabis dependence	Phase 2/3	ClinicalTrials.gov	7	7	https://conductscience.org/library/drugs?q=MONDO_0005689
dementia	Phase 2/3	ClinicalTrials.gov	7	7	https://conductscience.org/library/drugs?q=MONDO_0001627
Agitation	Phase 2	ClinicalTrials.gov	6	6	https://conductscience.org/library/drugs?q=HP_0000713
cancer pain	Phase 3	ClinicalTrials.gov	6	6	https://conductscience.org/library/drugs?q=EFO_0801084
fibromyalgia	Phase 2/3	ClinicalTrials.gov	6	6	https://conductscience.org/library/drugs?q=MONDO_0005546
neuropathic pain	Phase 3	ClinicalTrials.gov	6	6	https://conductscience.org/library/drugs?q=EFO_0005762

1 to 10 of 98Source Open Targets

See all 98 diseases

Trials305

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 19 more rest on that reading alone and are shown because the trials' posted result groups or NLM's indexing of their papers name the drug. 83 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT01606137	A Study of the Long-term Safety of Sativex Use	Phase 3	507	2012-08-23	tetrahydrocannabinol	Its name	ClinicalTrials.gov
NCT05820685	Dronabinol On the Pain Experience	Phase 4	484	2025-06-11	dronabinol	Its name	ClinicalTrials.gov
NCT00391079	Sativex Versus Placebo When Added to Existing Treatment for Central Neuropathic Pain in MS	Phase 3	339	2012-07-04	delta-9-tetrahydrocannabinol	Its name	ClinicalTrials.gov
NCT03655717	Using Imaging to Assess Effects of THC on Brain Activity		316	2022-07-28	dronabinol	Its name	ClinicalTrials.gov
NCT01964404	Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?	Phase 1	263	2025-12-09	dronabinol	Its name	ClinicalTrials.gov
NCT00710554	A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia	Phase 3	246	2012-09-14	delta-9-tetrahydrocannabinol/cannabidiol	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT00757822	Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients		216	2016-05-13	dronabinol	Its name	ClinicalTrials.gov
NCT02849587	The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking	Phase 1/2	199	2022-01-04	cannabis	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT00711646	A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis.	Phase 3	189	2012-09-14	tetrahydrocannabinol	Its name	ClinicalTrials.gov
NCT00674609	A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy	Phase 3	177	2012-08-13	tetrahydrocannabinol extract, tetrahydrocannabinol:cannabidiol extract	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov

1 to 10 of 305

See all 305 trials

Comparisons in its trials54

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Standard of Care + Dronabinol vs Standard of Care: Number of Participants Discharged Form Hospital With a Prescription for an Opioid Medication	144 of 234	133 of 235	469	NCT05820685	Trial comparisons
Standard of Care + Dronabinol vs Standard of Care: Number of Participants That Have Incidences of Opioid-related Complications, Such as Ileus, Aspiration, Unplanned Intubation, Unplanned Admission to an Intensive Care Unit, and Use of an Opioid-reversal Agent.	13 of 234	10 of 235	469	NCT05820685	Trial comparisons
Standard of Care + Dronabinol vs Standard of Care: Number of Participants Discharged Form Hospital Without a Prescription for an Opioid Medication	90 of 234	102 of 235	469	NCT05820685	Trial comparisons
Standard of Care + Dronabinol vs Standard of Care: deaths from any cause	4 of 234	5 of 235	469	NCT05820685	Trial comparisons
Standard of Care + Dronabinol vs Standard of Care: serious adverse events	13 of 234	10 of 235	469	NCT05820685	Trial comparisons
Sativex vs Placebo: Number of Patients With at Least 30% Improvement in Numerical Rating Scale (NRS) Pain Score From Baseline	84 of 167	77 of 172	339	NCT00391079	Trial comparisons
Sativex vs Placebo: serious adverse events	3 of 167	2 of 172	339	NCT00391079	Trial comparisons
Sativex vs Placebo: Incidence of Adverse Events as a Measure of Subject Safety	102 of 124	46 of 65	189	NCT00711646	Trial comparisons
Sativex vs Placebo: serious adverse events	4 of 124	3 of 65	189	NCT00711646	Trial comparisons
Dronabinol- Experimental Therapy vs Ondansetron-control Therapy: serious adverse events	13 of 92	10 of 88	180	NCT00757822	Trial comparisons

1 to 10 of 54

See all 54 comparisons in its trials

Papers from its trials109

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42032682	RESULT	1	PubMed
33730032	RESULT	1	PubMed
31333569	RESULT	1	PubMed
28576350	RESULT	1	PubMed
27403414	RESULT	1	PubMed
26883879	RESULT	1	PubMed
26858214	RESULT	1	PubMed
25733754	RESULT	1	PubMed
24420962	RESULT	1	PubMed
23220273	RESULT	1	PubMed

1 to 10 of 109

See all 109 papers from its trials

Tests in its trials57

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Verbal Learning	20	8	ConductCognition
Symbol Coding	17	5	ConductCognition
Paced Visual Serial Addition Test	9	4	ConductCognition
Continuous Performance Test	6	2	ConductCognition
1-Back Task	6	6	ConductCognition
2-Back Task	6	6	ConductCognition
Digit Span Test	4	1	ConductCognition
Psychomotor Vigilance Task	3	1	ConductCognition
Dot-Probe Task	2	1	ConductCognition
Go/No-Go Task	2	2	ConductCognition

1 to 10 of 57

See all 57 tests in its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL465

GET https://conductscience.org/api/drugs/v1/CHEMBL465/diseases?page=2

API reference For AI assistants