Drug · CHEMBL686
MEFENAMIC ACID
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. MEFENAMIC ACID. Drugs and targets, record CHEMBL686. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL686
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Brand names
- Contraflam, Dysman-250, Dysman-500, Meflam 250, Meflam 500, Mendys, Opustan 250, Opustan 500, Ponstan, Ponstan fte, Ponstel
- ChEMBL
- Other names
- Acide mefenamique, Acido mefenamico, CI-473, CN-35355, Gardan, INF-3355, J2.344B, M01AG01, Mefenamate, Mefenaminic acid, Mephenamic acid, Mephenaminic acid, NSC-94437
- ChEMBL
- Open Targets' highest stage
- Approval, for 2 of its 5 diseases, from ATC, DailyMed and TTD
- Open Targets
Targets2
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| PTGS1 | Cyclooxygenase | Cyclooxygenase inhibitor | INHIBITOR | https://conductscience.org/library/genes/5742 |
| PTGS2 | Cyclooxygenase | Cyclooxygenase inhibitor | INHIBITOR | https://conductscience.org/library/genes/5743 |
Source ChEMBL
Diseases5
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| Dysmenorrhea | Approval | DailyMed and TTD | 10 | 2 | https://conductscience.org/library/drugs?q=HP_0100607 |
| Menorrhagia | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0000132 |
| Pain | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0012531 |
| hemorrhage | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MP_0001914 |
| rheumatic disorder | Approval | ATC | 1 | 0 | https://conductscience.org/library/drugs?q=MONDO_0005554 |
Source Open Targets
Trials13
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT05064449 | A Study of Soticlestat With Itraconazole and Mefenamic Acid in Healthy Adults | Phase 1 | 28 | 2023-10-03 | mefenamic acid | Its name | ClinicalTrials.gov |
| NCT02183025 | Efficacy and Safety Study of Meloxicam Versus Mefenamic Acid in Patients With Dysmenorrhea | Phase 2 | 337 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT02943655 | Treatment of Heavy and/or Prolonged Menstrual Bleeding Without Organic Cause | Phase 3 | 240 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT01295294 | Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA) | Phase 4 | 187 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT02417337 | Efficacy of Different Drugs to Control Post Root Canal Treatment Pain | Phase 2 | 185 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT01060696 | Efficacy of Mefenamic Acid and Hyoscine for Pain Relief During Saline Infusion Sonohysterography in Infertile Women | 138 | mefenamic acid | Its name | ClinicalTrials.gov | ||
| NCT06369012 | Management of Abnormal Uterine Bleeding | 130 | mefenamic acid | Its name | ClinicalTrials.gov | ||
| NCT03323671 | Preemptive Analgesia for Primary Dysmenorrhoea | Phase 2/3 | 84 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT07466342 | Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women | Phase 4 | 60 | mefenamic acid | Its name | ClinicalTrials.gov | |
| NCT04902105 | Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active Metabolite | Phase 1 | 38 | mefenamic acid | Its name | ClinicalTrials.gov |
1 to 10 of 13
See all 13 trialsComparisons in its trials0
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
None in this release.
Papers from its trials8
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL686
GET https://conductscience.org/api/drugs/v1/CHEMBL686/targets