Drug · CHEMBL985
UREA
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. UREA. Drugs and targets, record CHEMBL985. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL985
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Brand names
Aquadrate, Balneum plus, Calmurid, Eucerin, Flexifoot, Flexitol, Hydromol intensive, Nutraplus, Sential e, St.james balm, Sterile urea, Urea component of alphaderm, Urea component of calmurid hc, Urea component of carmol hc, Urea component of u-cort, Ureaphil
- ChEMBL
- Other names
- Azodicarboxylic acid-diamide, Carbamide, E-927A, E927b, INS NO.927A, INS-927A, NSC-34375
- ChEMBL
Targets0
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
None in this release.
Diseases13
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 13Source Open Targets
See all 13 diseasesTrials32
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 1 more rests on that reading alone and is shown because the trial's posted result groups or NLM's indexing of its papers name the drug. 19 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT00296036 | Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer | Phase 3 | 137 | 2017-03-16 | urea | Its name | ClinicalTrials.gov |
| NCT02905825 | Urea Breath Test (UBT) With Breath Hp System /BreathID Hp Lab System Pediatrics | Phase 3 | 54 | 2018-07-05 | urea | Its name | ClinicalTrials.gov |
| NCT03901144 | A NOVel Moisturiser for Atopic Dermatitis: Effect on the Skin Barrier | Phase 2 | 50 | 2021-12-20 | urea | Its name | ClinicalTrials.gov |
| NCT01065714 | A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis | Phase 4 | 20 | 2013-04-25 | eucerin lotion | Open Targets' reading, confirmed by the trial's result groups | ClinicalTrials.gov |
| NCT00667589 | Sorafenib-induced Hand- Foot Skin Reaction Treatment | Phase 2 | 6 | 2013-05-27 | urea | Its name | ClinicalTrials.gov |
| NCT04588207 | Urea for Chronic Hyponatremia | Phase 2 | 2 | 2024-05-20 | urea | Its name | ClinicalTrials.gov |
| NCT01934829 | Urea Cream Treatment Sorafenib-Associated HSFR in HCC | Phase 2 | 871 | urea | Its name | ClinicalTrials.gov | |
| NCT03212625 | The Effect of Urea Cream on Sorafenib-associated Hand-Foot Skin Reaction | Phase 4 | 288 | urea | Its name | ClinicalTrials.gov | |
| NCT05348278 | Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome | Phase 2/3 | 214 | urea | Its name | ClinicalTrials.gov | |
| NCT06391034 | Magnetic Resonance (MR) Imaging With Hyperpolarized 13C-Pyruvate +/- 13C,15N-Urea in Patients With Prostate Cancer | Phase 2 | 161 | urea | Its name | ClinicalTrials.gov |
1 to 10 of 32
See all 32 trialsComparisons in its trials7
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Urea/Lactic Acid Cream vs Placebo Cream: serious adverse events | 0 of 67 | 0 of 63 | 130 | NCT00296036 | Trial comparisons |
| Urea vs No Urea: Number and Proportion of Participants Who Thought the Medication Was Acceptable | 1 of 2 | 0 of 2 | 4 | NCT04588207 | Trial comparisons |
| Urea vs No Urea: Number and Percentage of Participants Enrolled Who Completed the Study | 2 of 2 | 2 of 2 | 4 | NCT04588207 | Trial comparisons |
| Urea vs No Urea: Number and Percentage of Participants Who Met Inclusion/Exclusion Criteria and Were Enrolled in the Study | 2 of 2 | 2 of 2 | 4 | NCT04588207 | Trial comparisons |
| Urea vs No Urea: Number and Proportion of Participants Enrolled in the Study With Adverse Events Related to the Use of Urea | 1 of 2 | 0 of 2 | 4 | NCT04588207 | Trial comparisons |
| Urea vs No Urea: deaths from any cause | 0 of 2 | 0 of 2 | 4 | NCT04588207 | Trial comparisons |
| Urea vs No Urea: serious adverse events | 0 of 2 | 0 of 2 | 4 | NCT04588207 | Trial comparisons |
Papers from its trials11
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials1
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome |
|---|---|---|
| Go/No-Go Task | 1 | 1 |
Source ConductCognition
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL985
GET https://conductscience.org/api/drugs/v1/CHEMBL985/trials?page=2