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Gene · 1022

CDK7: cyclin dependent kinase 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDK7: cyclin dependent kinase 7. Genes, record 1022. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1022

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Gene

Symbol
CDK7
HGNC
Name
cyclin dependent kinase 7
HGNC
NCBI Gene ID
1022
NCBI Gene
HGNC ID
HGNC:1778
HGNC
Ensembl
ENSG00000134058
NCBI Gene
Aliases
CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50613Cyclin-dependent kinase 734654Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US RE050776 E12026-02-03274P50613Espacenet
EP 4650780 A22025-11-191580P50613Espacenet
JP 2025517970 A2025-06-121580P50613Espacenet
US 12168663 B22024-12-174P50613Espacenet
US 12098154 B22024-09-24274P50613Espacenet
JP 2024123008 A2024-09-105794P50613Espacenet
US 11932625 B22024-03-191P50613Espacenet
JP 2023052006 A2023-04-11274P50613Espacenet
US 11504404 B22022-11-22186P50613Espacenet
US 11446398 B22022-09-2021320P50613Espacenet

1 to 10 of 66

See all 66 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALVOCIDIBCHEMBL428690Cyclin-dependent kinase 7 inhibitorINHIBITORChEMBL
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
BMS-387032CHEMBL296468Cyclin-dependent kinase 7 inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RGB-286638CHEMBL3545083Cyclin-dependent kinase 7 inhibitorINHIBITORChEMBL
RONICICLIBCHEMBL4442620Cyclin-dependent kinase inhibitorINHIBITORChEMBL
SELICICLIBCHEMBL14762Cyclin-dependent kinase 7 inhibitorINHIBITORChEMBL
ZOTIRACICLIBCHEMBL1944698Cyclin-dependent kinase 7 inhibitorINHIBITORChEMBL

Trials70

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04493099ALVOCIDIBPHASE1/PHASE2ClinicalTrials.gov
NCT03969420ALVOCIDIBPHASE22022-10-19ClinicalTrials.gov
NCT03904628ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03774446SELICICLIBPHASE2ClinicalTrials.gov
NCT03738111ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03593915ALVOCIDIBPHASE1/PHASE22022-10-21ClinicalTrials.gov
NCT03563560ALVOCIDIBPHASE1ClinicalTrials.gov
NCT03441555ALVOCIDIBPHASE1ClinicalTrials.gov
NCT03298984ALVOCIDIBPHASE12021-05-24ClinicalTrials.gov
NCT03224104ZOTIRACICLIBPHASE12025-11-26ClinicalTrials.gov

1 to 10 of 70

See all 70 trials

NIH grants2,514

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDK7 papersNewest fiscal year
P30CA016672Cancer Center Support Grant302025
P30CA008748Cancer Center Support Grant292025
P30CA076292Moffitt Cancer Center Support Grant152025
P30CA014051Cancer Center Support (Core) Grant122025
P30CA021765Cancer Center Support Grant (CCSG)122025
P01CA092584Structural Cell Biology of DNA Repair Machines112025
P30CA046934University of Colorado Cancer Center Support Grant102025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant92025
R35GM139550Mechanisms of RNA polymerase II transcription regulation92025
P30CA016059Massey Cancer Center - Cancer Center Support Grant82025

1 to 10 of 2,514Source NIH's project files

See all 2,514 nih grants

Papers3,996

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Machine learning-guided discovery of a novel natural CDK7 inhibitor for triple-negative breast cancer.Comput Biol Chem202642826577PubTator, text miningPubMed
CDK7, CDK9, or CDK11 inhibition reduces neutrophil-driven inflammation and tissue damage in experimental autoimmune models.Cell Commun Signal202642823736PubTator, text miningPubMed
Sensitizing tumor response to topoisomerase I antibody-drug conjugate by selective CDK7 inhibition.Sci Adv202642814835PubTator, text miningPubMed
Association of miR-199a-3p and CDK7 expression with clinicopathological features of breast cancer.Mol Biol Rep202642804014PubTator, text miningPubMed
Transcriptomic Plasticity and Its Spatial Architecture Shape Melanoma Response to Immunotherapy and Its Combination With BRAF/MEKi.J Clin Oncol202642771837PubTator, text miningPubMed
Correction: Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax.J Exp Clin Cancer Res202642760550PubTator, text miningPubMed
MNAT1 in gastrointestinal cancers: mechanistic insights and therapeutic strategies-a narrative review.J Gastrointest Oncol202642703445PubTator, text miningPubMed
FAIMS-GPF XL-MS: crosslinking-mass spectrometry based on gas-phase fractionation.Nat Commun202642642374PubTator, text miningPubMed
Targeting CDK7 to overcome hypomethylating agent resistance in acute myeloid leukemia.Blood Res202642635915PubTator, text miningPubMed
Cell cycle regulators contribute to extravillous trophoblast cell differentiation and function.Hum Reprod202642630068PubTator, text miningPubMed

1 to 10 of 3,996

See all 3,996 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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