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Gene · 10280

SIGMAR1: sigma receptor chaperone 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIGMAR1: sigma receptor chaperone 1. Genes, record 10280. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10280

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Gene

Symbol
SIGMAR1
HGNC
Name
sigma receptor chaperone 1
HGNC
NCBI Gene ID
10280
NCBI Gene
HGNC ID
HGNC:8157
HGNC
Ensembl
ENSG00000147955
NCBI Gene
Aliases
ALS16, DSMA2, HMNR2, OPRS1, S1R, SIG-1R, SIGMA1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99720Sigma non-opioid intracellular receptor 12235Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463534Q99720Espacenet
EP 4650780 A22025-11-192987Q99720Espacenet
JP 2025147176 A2025-10-0612287Q99720Espacenet
JP 2025529142 A2025-09-043965Q99720Espacenet
JP 2025529142 A2025-09-047720Q99720Espacenet
US 12371689 B22025-07-293965Q99720Espacenet
US 12371689 B22025-07-297720Q99720Espacenet
JP 2025517970 A2025-06-122987Q99720Espacenet
JP 2025028160 A2025-02-2812287Q99720Espacenet
KR 1020250010750 A2025-01-2112287Q99720Espacenet

1 to 10 of 39

See all 39 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CARBETAPENTANECHEMBL73234Sigma opioid receptor agonistAGONISTChEMBL
CARBETAPENTANE CITRATECHEMBL1256696Sigma opioid receptor agonistAGONISTChEMBL
DEXTROMETHORPHANCHEMBL52440Sigma opioid receptor agonistAGONISTChEMBL
DEXTROMETHORPHAN HYDROBROMIDECHEMBL1256818Sigma opioid receptor agonistAGONISTChEMBL
DEXTROMETHORPHAN POLISTIREXCHEMBL1201461Sigma opioid receptor agonistAGONISTChEMBL
FENFLURAMINECHEMBL87493Sigma opioid receptor antagonistANTAGONISTChEMBL
FENFLURAMINE HYDROCHLORIDECHEMBL2106217Sigma opioid receptor antagonistANTAGONISTChEMBL
PENTAZOCINECHEMBL100116Sigma opioid receptor modulatorMODULATORChEMBL
PENTAZOCINE HYDROCHLORIDECHEMBL3989510Sigma opioid receptor modulatorMODULATORChEMBL
PENTAZOCINE LACTATECHEMBL3989509Sigma opioid receptor modulatorMODULATORChEMBL

Trials87

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07593222DEXTROMETHORPHANPHASE1/PHASE2ClinicalTrials.gov
NCT07583589DEXTROMETHORPHANPHASE2ClinicalTrials.gov
NCT07555171FENFLURAMINEClinicalTrials.gov
NCT07523048DEXTROMETHORPHANPHASE2ClinicalTrials.gov
NCT07503444FENFLURAMINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT07112365FENFLURAMINEPHASE4ClinicalTrials.gov
NCT06958692DEXTROMETHORPHANPHASE3ClinicalTrials.gov
NCT06957223DEXTROMETHORPHANClinicalTrials.gov
NCT06716645DEXTROMETHORPHANPHASE42026-02-20ClinicalTrials.gov
NCT06598449FENFLURAMINEPHASE4ClinicalTrials.gov

1 to 10 of 87

See all 87 trials

NIH grants971

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIGMAR1 papersNewest fiscal year
ZIADA000206Biological And Biochemical Characterization Of Sigma Receptors332025
ZIADA000549Neurobiological Basis of Neuronal Survival132025
P20GM121307Center for Redox Biology and Cardiovascular Disease52025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)52025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.42025
P30EY016665Core Grant for Vision Research42025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens32025
P30CA056036Translational Research in Cancer32025
P40OD010440Caenorhabditis Genetics Center32025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism32025

1 to 10 of 971Source NIH's project files

See all 971 nih grants

Papers1,549

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of novel dual μOR/σ1R ligands as potent analgesics with reduced tolerance liability and improved safety profiles.Eur J Med Chem202642826517PubTator, text miningPubMed
Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation.Ren Fail202642785975PubTator, text miningPubMed
The Sigma-1 Receptor as a Novel Target in the Neuroprotective Effects of Cannabidiol and Cannabigerol Against Mitochondrial Damage in Cultured Cerebellar Granule Neurons.ChemMedChem202642785968PubTator, text miningPubMed
Intracellular Crosstalk Between NMDA and Sigma-1 Receptors: A Novel Mechanistic Insight Relevant to Neuropsychiatric Pharmacotherapy.Cells202642782789PubTator, text miningPubMed
A neuroprotective target in the shadows: a scoping review of pharmacological gaps in σ1R agonists for glutamate-induced neurotoxicity.Front Pharmacol202642769292PubTator, text miningPubMed
Pharmacological insights into fluvoxamine maleate: σ1 receptor agonism, multimodal mechanisms, and therapeutic repositioning.Curr Opin Pharmacol202642753377PubTator, text miningPubMed
Investigating oral blarcamesine for treatment of early Alzheimer's disease.Expert Opin Pharmacother202642745524PubTator, text miningPubMed
Biallelic SIGMAR1 variants in early-onset distal hereditary motor neuropathy: A Japanese case series.J Neuromuscul Dis202642641169PubTator, text miningPubMed
Anticonvulsant effects, safety, and sex-dependent molecular signatures of cannabidiol treatment in a preclinical model of audiogenic epilepsy.Front Pharmacol202642630256PubTator, text miningPubMed
Involvement of NLRP3 Inflammasome in Methamphetamine Augmentation of SARS-CoV-2 N-Protein-Induced Neuroinflammation in Rat Microglial Cells.Int J Mol Sci202642589614PubTator, text miningPubMed

1 to 10 of 1,549

See all 1,549 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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