Gene · 10733
PLK4: polo like kinase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLK4: polo like kinase 4. Genes, record 10733. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10733
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00444 | Serine/threonine-protein kinase PLK4 | 970 | 19 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 106 | O00444 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4637 | O00444 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4637 | O00444 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 106 | O00444 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7748 | O00444 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64478 | O00444 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167449 | O00444 | Espacenet |
| US 10752612 B2 | 2020-08-25 | 2 | O00444 | Espacenet |
| JP 2020062004 A | 2020-04-23 | 1137 | O00444 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 7748 | O00444 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04730258 | CFI-400945 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04176848 | CFI-400945 | PHASE2 | 2024-08-09 | ClinicalTrials.gov |
| NCT03624543 | CFI-400945 | PHASE2 | ClinicalTrials.gov | |
| NCT03385655 | CFI-400945 | PHASE2 | ClinicalTrials.gov | |
| NCT03187288 | CFI-400945 | PHASE1 | ClinicalTrials.gov |
NIH grants1,134
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLK4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 13 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 11 | 2025 |
| ZIABC011459 | Control of centrosome biogenesis | 11 | 2025 |
| R01GM074207 | Analysis of Centrosome Dynamics | 9 | 2025 |
| R01GM088253 | Template-based replication of the centriole organelle | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| U54CA163071 | (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership # | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,134Source NIH's project files
See all 1,134 nih grantsPapers2,106
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Skeletal muscle dedifferentiation requires centrosomes. | NPJ Regen Med | 2026 | 42786221 | PubTator, text mining | PubMed |
| The Centriole Biogenesis Cycle: Temporal Mechanisms, Autonomy and Coupling to the Cell Cycle and Other Cellular Clocks. | Adv Exp Med Biol | 2026 | 42782439 | PubTator, text mining | PubMed |
| CD20 targeted nanomedicine enhances anti-tumor immunity in diffuse large B-cell lymphoma by activating cGAS/STING pathway. | Cancer Lett | 2026 | 42762966 | PubTator, text mining | PubMed |
| Divergent microtubule-organizing center strategies in mammalian gametogenesis. | Trends Open | 2026 | 42761981 | PubTator, text mining | PubMed |
| Design, Synthesis, and Biological Activity Evaluation of Quinazoline-Based PLK4 Inhibitors. | Biomedicines | 2026 | 42652193 | PubTator, text mining | PubMed |
| Centriolar satellites regulate CEP350 mRNA stability and centrosome amplification. | Mol Biol Cell | 2026 | 42555824 | PubTator, text mining | PubMed |
| Discovery of ZSL-M028: A Potent, Selective and Orally Available Quinazoline-Based PLK4 Inhibitor Targeting TRIM37-Amplified Neuroblastoma. | J Med Chem | 2026 | 42463132 | PubTator, text mining | PubMed |
| Comprehensive multi-omic dissection and AI-prioritized target identification in inverted papilloma-associated sinonasal squamous cell carcinoma. | NPJ Precis Oncol | 2026 | 42432132 | PubTator, text mining | PubMed |
| Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification. | Cancer Cell Int | 2026 | 42316241 | PubTator, text mining | PubMed |
| Two distinct causes contribute to the low efficiency of human pre-implantation development. | Cell | 2026 | 42276044 | PubTator, text mining | PubMed |
1 to 10 of 2,106
See all 2,106 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10733
GET https://conductscience.org/api/genes/v1/10733/patents