ConductScience.org, home

Gene · 1129

CHRM2: cholinergic receptor muscarinic 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CHRM2: cholinergic receptor muscarinic 2. Genes, record 1129. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1129

On this page

Gene

Symbol
CHRM2
HGNC
Name
cholinergic receptor muscarinic 2
HGNC
NCBI Gene ID
1129
NCBI Gene
HGNC ID
HGNC:1951
HGNC
Ensembl
ENSG00000181072
NCBI Gene
Aliases
HM2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08172Muscarinic acetylcholine receptor M246617Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1040P08172Espacenet
JP 2026004568 A2026-01-1441211P08172Espacenet
JP 2026004568 A2026-01-1441212P08172Espacenet
JP 2026004568 A2026-01-1441213P08172Espacenet
JP 2026004568 A2026-01-1441214P08172Espacenet
JP 2026004568 A2026-01-1441215P08172Espacenet
JP 2026004568 A2026-01-1441216P08172Espacenet
EP 4641201 A22025-10-294870P08172Espacenet
JP 2025529142 A2025-09-04927P08172Espacenet
US 12371689 B22025-07-29927P08172Espacenet

1 to 10 of 78

See all 78 patents

Drugs31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
ALCURONIUMCHEMBL3305985Muscarinic acetylcholine receptor M2 positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
ASM-024CHEMBL3707249Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL
ATROPINECHEMBL517712Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL
ATROPINE SULFATECHEMBL2146146Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL
BATEFENTEROLCHEMBL3039518Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL
BETHANECHOLCHEMBL1482Muscarinic acetylcholine receptor M2 agonistAGONISTChEMBL
BETHANECHOL CHLORIDECHEMBL1768Muscarinic acetylcholine receptor M2 agonistAGONISTChEMBL
DARIFENACINCHEMBL1346Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL
DARIFENACIN HYDROBROMIDECHEMBL1200935Muscarinic acetylcholine receptor M2 antagonistANTAGONISTChEMBL

1 to 10 of 31

See all 31 drugs

Trials500

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07577661OXYBUTYNINPHASE1/PHASE2ClinicalTrials.gov
NCT07571148TROSPIUM CHLORIDEClinicalTrials.gov
NCT07541378GLYCOPYRRONIUMClinicalTrials.gov
NCT07537166ATROPINEClinicalTrials.gov
NCT07525375GLYCOPYRRONIUMPHASE2ClinicalTrials.gov
NCT07494799ATROPINEClinicalTrials.gov
NCT07489911GLYCOPYRRONIUMClinicalTrials.gov
NCT07473310SOLIFENACIN SUCCINATEPHASE4ClinicalTrials.gov
NCT07456488ATROPINEPHASE2ClinicalTrials.gov
NCT07429734SOLIFENACINPHASE3ClinicalTrials.gov

1 to 10 of 500

See all 500 trials

NIH grants1,251

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRM2 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).342025
R01EY011500Structure-function studies of visual arrestin62025
P50AA012870Center for the Translational Neuroscience of Alcoholism52025
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol52025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIAAA000301Integrative genetics of behavior with high throughput technologies42025
R01AA006059Effects of alcohol on sleep/activity rhythms: Focus on Hypocretin/Orexin32025
P30AG066507Johns Hopkins Alzheimer's Disease Research Center22025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
P60AA010760Behavioral Genomics of Alcohol Neuroadaptation22025

1 to 10 of 1,251Source NIH's project files

See all 1,251 nih grants

Papers1,659

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Delayed late ventricular depolarization is associated with inflammation in epicardial Fat Among females: a New avenue in cardiac electrophysiology.Front Cardiovasc Med202642769221PubTator, text miningPubMed
Molecular mechanisms of phytochemicals from Zanthoxylum nitidum (Roxb.) DC. against hepatocellular carcinoma: insights from network pharmacology, molecular docking, and bioinformatics.Artif Cells Nanomed Biotechnol202642498300PubTator, text miningPubMed
SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands.ACS Chem Biol202642258302PubTator, text miningPubMed
Multivalent antibody-based conjugates as new tools for tailored modulation of G protein-coupled receptors.Br J Pharmacol202642225334PubTator, text miningPubMed
Pan-cancer neurotransmitter receptor alterations define neuroregulatory subtypes with prognostic significance.Cell Rep202642096332PubTator, text miningPubMed
Autonomic Receptor Autoantibodies in Complex Regional Pain Syndrome and Other Chronic Pain Conditions: A Cross-Sectional Analysis.Biomedicines202642072485PubTator, text miningPubMed
Phosphorylation site topology governs the functional dynamics of arrestin recruitment to GPCRs.Res Sq202642040930PubTator, text miningPubMed
Genetic Variants Associated with Life Expectancy in Patients with Chagas Disease.Med Sci (Basel)202641892852PubTator, text miningPubMed
Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Commun Biol202641857244PubTator, text miningPubMed
b -Hurwitz numbers from refined topological recursion.Math Ann202641841125PubTator, text miningPubMed

1 to 10 of 1,659

See all 1,659 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1129

GET https://conductscience.org/api/genes/v1/1129/patents?page=2