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Gene · 1131

CHRM3: cholinergic receptor muscarinic 3

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. CHRM3: cholinergic receptor muscarinic 3. Genes, record 1131. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1131

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
CHRM3
HGNC
Name
cholinergic receptor muscarinic 3
HGNC
NCBI Gene ID
1131
NCBI Gene
HGNC ID
HGNC:1952
HGNC
Ensembl
ENSG00000133019
NCBI Gene
Aliases
EGBRS, HM3, PBS, m3AChR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20309Muscarinic acetylcholine receptor M35905Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1041P20309Espacenet
JP 2026004568 A2026-01-1441217P20309Espacenet
EP 4641201 A22025-10-291162P20309Espacenet
JP 2025529142 A2025-09-04928P20309Espacenet
JP 2025118768 A2025-08-133P20309Espacenet
US 12371689 B22025-07-29928P20309Espacenet
JP 2025517969 A2025-06-121162P20309Espacenet
JP 2025032204 A2025-03-1126358P20309Espacenet
JP 2025032204 A2025-03-1126360P20309Espacenet
EP 4461818 A22024-11-1326358P20309Espacenet

1 to 10 of 61

See all 61 patents

Drugs82

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLCHOLINECHEMBL667Muscarinic acetylcholine receptor M3 agonistAGONISTChEMBL
ACETYLCHOLINE CHLORIDECHEMBL1184Muscarinic acetylcholine receptor M3 agonistAGONISTChEMBL
ACLIDINIUMCHEMBL1194325Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
ACLIDINIUM BROMIDECHEMBL551466Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
AFACIFENACINCHEMBL3545165Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
ANISOTROPINECHEMBL1186610Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
ANISOTROPINE METHYLBROMIDECHEMBL1578Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
ASM-024CHEMBL3707249Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
ATROPINECHEMBL517712Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL
ATROPINE SULFATECHEMBL2146146Muscarinic acetylcholine receptor M3 antagonistANTAGONISTChEMBL

1 to 10 of 82

See all 82 drugs

Trials1,177

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07595796GLYCOPYRRONIUM BROMIDEClinicalTrials.gov
NCT07577661OXYBUTYNINPHASE1/PHASE2ClinicalTrials.gov
NCT07571148TROSPIUM CHLORIDEClinicalTrials.gov
NCT07546981GLYCOPYRRONIUM BROMIDEPHASE3ClinicalTrials.gov
NCT07541378UMECLIDINIUMClinicalTrials.gov
NCT07541378GLYCOPYRRONIUMClinicalTrials.gov
NCT07541378TIOTROPIUMClinicalTrials.gov
NCT07537166ATROPINEClinicalTrials.gov
NCT07525375GLYCOPYRRONIUMPHASE2ClinicalTrials.gov
NCT07494799ATROPINEClinicalTrials.gov

1 to 10 of 1,177

See all 1,177 trials

NIH grants3,784

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA047904Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025
P30ES006694Southwest Environmental Health Sciences Center62025
ZIADK031129Molecular basis of G protein-coupled receptor function62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA021765Cancer Center Support Grant (CCSG)52025

1 to 10 of 3,784Source NIH's project files

See all 3,784 nih grants

Papers4,237

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42795812PubTator, text miningPubMed
42769221PubTator, text miningPubMed
42738155PubTator, text miningPubMed
42735701PubTator, text miningPubMed
42711953PubTator, text miningPubMed
42700788PubTator, text miningPubMed
42688638PubTator, text miningPubMed
42561497PubTator, text miningPubMed
42511759PubTator, text miningPubMed
42497870PubTator, text miningPubMed

1 to 10 of 4,237

See all 4,237 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1131

GET https://conductscience.org/api/genes/v1/1131/patents?page=2