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Gene · 1132

CHRM4: cholinergic receptor muscarinic 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRM4: cholinergic receptor muscarinic 4. Genes, record 1132. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1132

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Gene

Symbol
CHRM4
HGNC
Name
cholinergic receptor muscarinic 4
HGNC
NCBI Gene ID
1132
NCBI Gene
HGNC ID
HGNC:1953
HGNC
Ensembl
ENSG00000180720
NCBI Gene
Aliases
HM4, M4R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08173Muscarinic acetylcholine receptor M447938Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441219P08173Espacenet
JP 2025529142 A2025-09-04929P08173Espacenet
US 12371689 B22025-07-29929P08173Espacenet
EP 4541896 A12025-04-23267P08173Espacenet
JP 2025010185 A2025-01-20267P08173Espacenet
JP 2024519329 A2024-05-102P08173Espacenet
JP 2024041871 A2024-03-2710P08173Espacenet
JP 2024041871 A2024-03-2711P08173Espacenet
JP 2023184465 A2023-12-28267P08173Espacenet
WO 2023243495 A2023-12-21267P08173Espacenet

1 to 10 of 30

See all 30 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
DAROTROPIUMCHEMBL2365940Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
DAROTROPIUM BROMIDECHEMBL2308782Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
GLYCOPYRRONIUMCHEMBL1201335Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
GLYCOPYRRONIUM TOSYLATECHEMBL3707243Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
SOFPIRONIUMCHEMBL3707224Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
SOFPIRONIUM BROMIDECHEMBL3707223Muscarinic acetylcholine receptor inhibitorINHIBITORChEMBL
TERODILINECHEMBL363295Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
TERODILINE HYDROCHLORIDECHEMBL539770Muscarinic acetylcholine receptor antagonistANTAGONISTChEMBL
XANOMELINECHEMBL21536Muscarinic acetylcholine receptor M4 agonistAGONISTChEMBL

1 to 10 of 11

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Trials123

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 123

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NIH grants458

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRM4 papersNewest fiscal year
ZIADK075020Muscarinic acetylcholine receptor subtypes: physiological roles52025
T32MH065215Postdoctoral Program in Functional Neurogenomics42025
P30CA086862Cancer Center Support Grant22025
R01MH062646Regulation of Signaling by mGluR522025
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes22025
R37NS034696Dopaminergic and Muscarinic Signaling in the Striatum22025
ZIAHL005801Genome-wide analysis of chromatin modifications22025
ZIAHL006030Epigenetic Regulation of T cell differentiation22025
K12CA090628Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic12025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens12025

1 to 10 of 458Source NIH's project files

See all 458 nih grants

Papers540

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Receptor Contribution Reallocation After Removal of Literature-Derived Weights: A Secondary Sensitivity Analysis of the Integrated Ki-DDD-TWAS Pipeline for Antipsychotic Lipid-Trait Prioritization.Cureus202642540671PubTator, text miningPubMed
The Design, Synthesis and Pharmacological Characterization of Potent Xanomeline-Based M1 and M4 mAChR Bitopic Ligands.J Med Chem202642503676PubTator, text miningPubMed
Uncovering G Protein-Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis.Ann Clin Transl Neurol202642163039PubTator, text miningPubMed
b -Hurwitz numbers from refined topological recursion.Math Ann202641841125PubTator, text miningPubMed
Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis.Front Immunol202641789083PubTator, text miningPubMed
The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study.PLoS Med202641770756PubTator, text miningPubMed
Prevalence of Circulating Autoantibodies Against G-Protein-Coupled Receptors as Potential Biomarkers for Long COVID: Preliminary Investigations.Int J Mol Sci202641751924PubTator, text miningPubMed
The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth.Int J Mol Sci202641751811PubTator, text miningPubMed
The "Immune Rebellion" from the Intestines to the Liver: A Vicious Cycle That Causes the Liver to Collapse.Metabolites202641745575PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed

1 to 10 of 540

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1132

GET https://conductscience.org/api/genes/v1/1132/patents?page=2