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Gene · 1196

CLK2: CDC like kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLK2: CDC like kinase 2. Genes, record 1196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1196

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Gene

Symbol
CLK2
HGNC
Name
CDC like kinase 2
HGNC
NCBI Gene ID
1196
NCBI Gene
HGNC ID
HGNC:2069
HGNC
Ensembl
ENSG00000176444
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49760Dual specificity protein kinase CLK24996Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440729P49760Espacenet
JP 2026004568 A2026-01-1440731P49760Espacenet
EP 4650780 A22025-11-198441P49760Espacenet
EP 4641201 A22025-10-298610P49760Espacenet
JP 2025517969 A2025-06-128610P49760Espacenet
JP 2025517970 A2025-06-128441P49760Espacenet
US 11446398 B22022-09-2013434P49760Espacenet
US 11446398 B22022-09-2013437P49760Espacenet
JP 2022524081 A2022-04-27116405P49760Espacenet
JP 2022524081 A2022-04-27116408P49760Espacenet

1 to 10 of 28

See all 28 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LORECIVIVINTCHEMBL4297639Dual specificity protein kinase CLK2 inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05603754LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04931667LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04520607LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04385303LORECIVIVINTPHASE32026-02-04ClinicalTrials.gov
NCT03928184LORECIVIVINTPHASE32026-02-13ClinicalTrials.gov
NCT03727022LORECIVIVINTPHASE22026-01-12ClinicalTrials.gov
NCT03706521LORECIVIVINTPHASE22026-03-04ClinicalTrials.gov
NCT03246399LORECIVIVINTPHASE1ClinicalTrials.gov
NCT03122860LORECIVIVINTPHASE22021-05-18ClinicalTrials.gov
NCT02536833LORECIVIVINTPHASE22020-09-16ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants437

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLK2 papersNewest fiscal year
P30CA014051Cancer Center Support (Core) Grant32025
P30CA076292Moffitt Cancer Center Support Grant32025
R01HL128239Genetic and molecular basis for SRSF2 mutations in myelodysplasia32025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes22025
P01CA269043Targeting the Epigenetic and Metabolic Control of EBV-Epithelial Cancers22025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA008748Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30CA044579University of Virginia Cancer Center Support Grant22025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)22025

1 to 10 of 437Source NIH's project files

See all 437 nih grants

Papers648

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative multi-omics analysis identifies histone methyltransferase SUV420H2 as a prognostic biomarker in clear cell renal cell carcinoma.Discov Oncol202642449034PubTator, text miningPubMed
Integrative phosphoproteomic analysis identifies functional roles of TRPM7 phosphosites in oncogenesis.Front Bioinform202642305666PubTator, text miningPubMed
A risk stratification framework based on ammonia-induced cell death signatures for prognostic assessment and therapeutic insights in colorectal cancer.Discov Oncol202642223795PubTator, text miningPubMed
Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.Sci Rep202642098349PubTator, text miningPubMed
Integrated network toxicology and multi-omics analysis reveals Benzo(a)pyrene-driven molecular networks and prognostic biomarkers in colon cancer.Int J Environ Health Res202642017488PubTator, text miningPubMed
Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases.J Med Chem202641837733PubTator, text miningPubMed
Systematic Examination of Gene Expression and Proteomic Evidence Across Tissues Supports the Role of Mitochondrial Dysregulation in ME/CFS.Int J Mol Sci202641752134PubTator, text miningPubMed
CLK1 is a potential tumor suppressor for NSCLC by regulating cell proliferation and immune infiltration.Front Cell Dev Biol202641737282PubTator, text miningPubMed
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies.Cell Oncol (Dordr)202641636961PubTator, text miningPubMed
White Rabbit in radio interferometry.Exp Astron (Dordr)202641492437PubTator, text miningPubMed

1 to 10 of 648

See all 648 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1196

GET https://conductscience.org/api/genes/v1/1196/patents?page=2