Gene · 1196
CLK2: CDC like kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CLK2: CDC like kinase 2. Genes, record 1196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1196
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49760 | Dual specificity protein kinase CLK2 | 499 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 40729 | P49760 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40731 | P49760 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8441 | P49760 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8610 | P49760 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8610 | P49760 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8441 | P49760 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13434 | P49760 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13437 | P49760 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 116405 | P49760 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 116408 | P49760 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LORECIVIVINT | CHEMBL4297639 | Dual specificity protein kinase CLK2 inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05603754 | LORECIVIVINT | PHASE3 | ClinicalTrials.gov | |
| NCT04931667 | LORECIVIVINT | PHASE3 | ClinicalTrials.gov | |
| NCT04520607 | LORECIVIVINT | PHASE3 | ClinicalTrials.gov | |
| NCT04385303 | LORECIVIVINT | PHASE3 | 2026-02-04 | ClinicalTrials.gov |
| NCT03928184 | LORECIVIVINT | PHASE3 | 2026-02-13 | ClinicalTrials.gov |
| NCT03727022 | LORECIVIVINT | PHASE2 | 2026-01-12 | ClinicalTrials.gov |
| NCT03706521 | LORECIVIVINT | PHASE2 | 2026-03-04 | ClinicalTrials.gov |
| NCT03246399 | LORECIVIVINT | PHASE1 | ClinicalTrials.gov | |
| NCT03122860 | LORECIVIVINT | PHASE2 | 2021-05-18 | ClinicalTrials.gov |
| NCT02536833 | LORECIVIVINT | PHASE2 | 2020-09-16 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants437
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CLK2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| R01HL128239 | Genetic and molecular basis for SRSF2 mutations in myelodysplasia | 3 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 2 | 2025 |
| P01CA269043 | Targeting the Epigenetic and Metabolic Control of EBV-Epithelial Cancers | 2 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 2 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 2 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 2 | 2025 |
1 to 10 of 437Source NIH's project files
See all 437 nih grantsPapers648
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative multi-omics analysis identifies histone methyltransferase SUV420H2 as a prognostic biomarker in clear cell renal cell carcinoma. | Discov Oncol | 2026 | 42449034 | PubTator, text mining | PubMed |
| Integrative phosphoproteomic analysis identifies functional roles of TRPM7 phosphosites in oncogenesis. | Front Bioinform | 2026 | 42305666 | PubTator, text mining | PubMed |
| A risk stratification framework based on ammonia-induced cell death signatures for prognostic assessment and therapeutic insights in colorectal cancer. | Discov Oncol | 2026 | 42223795 | PubTator, text mining | PubMed |
| Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients. | Sci Rep | 2026 | 42098349 | PubTator, text mining | PubMed |
| Integrated network toxicology and multi-omics analysis reveals Benzo(a)pyrene-driven molecular networks and prognostic biomarkers in colon cancer. | Int J Environ Health Res | 2026 | 42017488 | PubTator, text mining | PubMed |
| Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases. | J Med Chem | 2026 | 41837733 | PubTator, text mining | PubMed |
| Systematic Examination of Gene Expression and Proteomic Evidence Across Tissues Supports the Role of Mitochondrial Dysregulation in ME/CFS. | Int J Mol Sci | 2026 | 41752134 | PubTator, text mining | PubMed |
| CLK1 is a potential tumor suppressor for NSCLC by regulating cell proliferation and immune infiltration. | Front Cell Dev Biol | 2026 | 41737282 | PubTator, text mining | PubMed |
| Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. | Cell Oncol (Dordr) | 2026 | 41636961 | PubTator, text mining | PubMed |
| White Rabbit in radio interferometry. | Exp Astron (Dordr) | 2026 | 41492437 | PubTator, text mining | PubMed |
1 to 10 of 648
See all 648 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1196
GET https://conductscience.org/api/genes/v1/1196/patents?page=2