ConductScience.org, home

Gene · 134

ADORA1: adenosine A1 receptor

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ADORA1: adenosine A1 receptor. Genes, record 134. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/134

On this page

Gene

Symbol
ADORA1
HGNC
Name
adenosine A1 receptor
HGNC
NCBI Gene ID
134
NCBI Gene
HGNC ID
HGNC:262
HGNC
Ensembl
ENSG00000163485
NCBI Gene
Aliases
RDC7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30542Adenosine receptor A13265Ensembl, GeneID, HGNC

Source UniProt

Patents88

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1017P30542Espacenet
JP 2026004568 A2026-01-1436613P30542Espacenet
JP 2026004568 A2026-01-1436614P30542Espacenet
JP 2026004568 A2026-01-1436616P30542Espacenet
JP 2025529142 A2025-09-04327P30542Espacenet
US 12371689 B22025-07-29327P30542Espacenet
JP 2025062604 A2025-04-142669P30542Espacenet
JP 2025062604 A2025-04-142670P30542Espacenet
JP 2025062604 A2025-04-142672P30542Espacenet
JP 2025032204 A2025-03-1124223P30542Espacenet

1 to 10 of 88

See all 88 patents

Drugs26

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADENOSINECHEMBL477Adenosine receptor agonistAGONISTChEMBL
AMINOPHYLLINECHEMBL1370561Adenosine receptor antagonistANTAGONISTChEMBL
AMP579CHEMBL3545163Adenosine A1 receptor agonistAGONISTChEMBL
BAY1067197CHEMBL5314392Adenosine A1 receptor agonistAGONISTChEMBL
CAFFEINECHEMBL113Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINE CITRATECHEMBL1200569Adenosine receptor antagonistANTAGONISTChEMBL
CAPADENOSONCHEMBL3235279Adenosine A1 receptor partial agonistPARTIAL AGONISTChEMBL
DEFIBROTIDECHEMBL2108396Adenosine A1 receptor agonistAGONISTChEMBL
DERENOFYLLINECHEMBL592435Adenosine A1 receptor antagonistANTAGONISTChEMBL
FK453CHEMBL440115Adenosine A1 receptor antagonistANTAGONISTChEMBL

1 to 10 of 26

See all 26 drugs

Trials187

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07469852CAFFEINEPHASE1/PHASE2ClinicalTrials.gov
NCT07466732CAFFEINEEARLY_PHASE1ClinicalTrials.gov
NCT07456670CAFFEINEPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07262060CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07216365CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07086560ADENOSINEClinicalTrials.gov
NCT06972849CAFFEINE CITRATEClinicalTrials.gov
NCT06972108CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT06855108CAFFEINE CITRATEPHASE3ClinicalTrials.gov

1 to 10 of 187

See all 187 trials

NIH grants1,396

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADORA1 papersNewest fiscal year
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS122025
ZIADK031117Development of Drugs Acting at Adenosine Receptors102025
P30CA086862Cancer Center Support Grant42025
P20GM103395Alaska INBRE 5 One Health32025
P30CA008748Cancer Center Support Grant32025
P30DK056338Texas Medical Center Digestive Diseases Center32025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation32025
R01NS034773ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTION32025
R01NS127846Therapies for Epilepsy Prevention - Focus on Adenosine32025
R35GM128641Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation32025

1 to 10 of 1,396Source NIH's project files

See all 1,396 nih grants

Papers2,244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ADORA1 inhibition suppresses colon cancer development via hippo tumor suppressor pathway.Cell Death Differ202642763325PubTator, text miningPubMed
From phenotypic screening to target and compound prioritization for autosomal dominant polycystic kidney disease.SLAS Discov202642744122PubTator, text miningPubMed
Increased ADORA1 expression in pancreatic islets coincides with insulin secretory defects in human type 2 diabetes.J Biol Chem202642660457PubTator, text miningPubMed
Integrating single-cell transcriptomics and network pharmacology identifies ADORA1 as a candidate receptor for gastrodin derivatives in lung adenocarcinoma.Biomed Pharmacother202642659805PubTator, text miningPubMed
Targeting ERO1A Enhances Antitumor Immune Response by Recruiting CD8+ T Cells and Synergizing with PD-L1 Blockade in Liver Cancer.Cancer Immunol Res202642644613PubTator, text miningPubMed
Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility.Proc Natl Acad Sci U S A202642636369PubTator, text miningPubMed
Anticonvulsant effects, safety, and sex-dependent molecular signatures of cannabidiol treatment in a preclinical model of audiogenic epilepsy.Front Pharmacol202642630256PubTator, text miningPubMed
Delta-Band Dynamics of CaMKI-Positive Preoptic Neurons Encode Thermal Homeostatic Information.Neurosci Bull202642587252PubTator, text miningPubMed
Potential Gastric Cancer Biomarker in Gastric Juice: Adenosine and Its Role in the Immune Evasion Mechanism of Gastric Cancer.J Interferon Cytokine Res202642455003PubTator, text miningPubMed
Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors.Beilstein J Org Chem202642445721PubTator, text miningPubMed

1 to 10 of 2,244

See all 2,244 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/134

GET https://conductscience.org/api/genes/v1/134/patents?page=2