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Gene · 136

ADORA2B: adenosine A2b receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADORA2B: adenosine A2b receptor. Genes, record 136. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/136

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Gene

Symbol
ADORA2B
HGNC
Name
adenosine A2b receptor
HGNC
NCBI Gene ID
136
NCBI Gene
HGNC ID
HGNC:264
HGNC
Ensembl
ENSG00000170425
NCBI Gene
Aliases
ADORA2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29275Adenosine receptor A2b3324Ensembl, GeneID, HGNC

Source UniProt

Patents84

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436624P29275Espacenet
EP 4650780 A22025-11-194283P29275Espacenet
EP 4641202 A22025-10-29225P29275Espacenet
JP 2025529142 A2025-09-04329P29275Espacenet
US 12371689 B22025-07-29329P29275Espacenet
JP 2025517970 A2025-06-124283P29275Espacenet
JP 2025062604 A2025-04-142683P29275Espacenet
JP 2025032204 A2025-03-1124229P29275Espacenet
KR 1020250017231 A2025-02-04225P29275Espacenet
EP 4461818 A22024-11-1324229P29275Espacenet

1 to 10 of 84

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Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADENOSINECHEMBL477Adenosine receptor agonistAGONISTChEMBL
AMINOPHYLLINECHEMBL1370561Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINECHEMBL113Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINE CITRATECHEMBL1200569Adenosine receptor antagonistANTAGONISTChEMBL
DEFIBROTIDECHEMBL2108396Adenosine A2 receptor agonistAGONISTChEMBL
ETRUMADENANTCHEMBL4740383Adenosine A2b receptor antagonistANTAGONISTChEMBL
GS 6201CHEMBL260933Adenosine A2b receptor antagonistANTAGONISTChEMBL
LAS101057CHEMBL1672627Adenosine A2b receptor antagonistANTAGONISTChEMBL
OXTRIPHYLLINECHEMBL1200434Adenosine receptor antagonistANTAGONISTChEMBL
PENTOXIFYLLINECHEMBL628Adenosine A2 receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

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Trials295

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07469852CAFFEINEPHASE1/PHASE2ClinicalTrials.gov
NCT07466732CAFFEINEEARLY_PHASE1ClinicalTrials.gov
NCT07456670CAFFEINEPHASE2ClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07262060CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07216365CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov

1 to 10 of 295

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NIH grants855

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADORA2B papersNewest fiscal year
R01DK095491Indole dysbiosis and mucosal inflammation142025
I01BX002182Metabolic Regulation of Mucosal Inflammation82025
R01DK104713Metabolic Regulation of Inflammation by Microbial SCFA82025
ZIADK031117Development of Drugs Acting at Adenosine Receptors52025
P30DK056338Texas Medical Center Digestive Diseases Center42025
R01HL155950Targeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress Syndrome42025
R01HL146442The role of ferroptosis in red cell aging in vivo and in vitro32025
R01HL161004The paradoxical response to iron in pulmonary hypertension of sickle cell disease32025
T32GM135118Research Training of Anesthesiology Physician-Scientists32025
P01CA013106Targeting Transcription and Splicing in Cancer22025

1 to 10 of 855Source NIH's project files

See all 855 nih grants

Papers1,219

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Stromal spatial signatures of the classical adenosine pathway dictate prognosis in hepatocellular carcinoma.Immunol Lett202642815694PubTator, text miningPubMed
TRPV4-driven ATP release activates CFTR through ADORA2B and P2RY2 receptors in the airway epithelium.iScience202642707181PubTator, text miningPubMed
Increased ADORA1 expression in pancreatic islets coincides with insulin secretory defects in human type 2 diabetes.J Biol Chem202642660457PubTator, text miningPubMed
CD73 is associated with glycolysis-related metabolic features in head and neck squamous cell carcinoma.Eur J Oral Sci202642605821PubTator, text miningPubMed
Adenosine-A Regulator of Human Testicular Peritubular Cells.Andrology202642444403PubTator, text miningPubMed
Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose.bioRxiv202642427683PubTator, text miningPubMed
Clemastine alleviates cognitive dysfunction after SAH by targeting neuronal CNTN1 to regulate the ADA-adenosine pathway.Acta Pharmacol Sin202642337055PubTator, text miningPubMed
Expression of adenosine A1, A2A, A2B, and A3 receptors in ovarian cancer: their clinical potential in diagnosis and prognosis.Mol Biol Rep202642234312PubTator, text miningPubMed
Integration of network toxicology, WGCNA, and explainable machine learning to decipher the toxic molecular basis underlying DEGDB plasticizer-induced clear cell renal cell carcinoma (ccRCC) progression.
Comput Biol Chem202642224996PubTator, text miningPubMed
Targeting purinergic signaling and MTAP-associated metabolism in cancer: A functional immunometabolic convergence framework.Biochem Pharmacol202642082122PubTator, text miningPubMed

1 to 10 of 1,219

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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