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Gene · 140

ADORA3: adenosine A3 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADORA3: adenosine A3 receptor. Genes, record 140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/140

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Gene

Symbol
ADORA3
HGNC
Name
adenosine A3 receptor
HGNC
NCBI Gene ID
140
NCBI Gene
HGNC ID
HGNC:268
HGNC
Ensembl
ENSG00000282608
NCBI Gene
Aliases
A3AR, AD026
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P0DMS8Adenosine receptor A33185Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436625P0DMS8Espacenet
JP 2025062604 A2025-04-142684P0DMS8Espacenet
US 11673938 B22023-06-137P0DMS8Espacenet
US 11584923 B22023-02-21537P0DMS8Espacenet
US 11446398 B22022-09-202684P0DMS8Espacenet
US 11400116 B22022-08-02192P0DMS8Espacenet
JP 2022524081 A2022-04-27105655P0DMS8Espacenet
US 10772934 B22020-09-15978P0DMS8Espacenet
US 10292374 B22019-05-21264P0DMS8Espacenet
JP 2019054813 A2019-04-11217060P0DMS8Espacenet

1 to 10 of 60

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Drugs12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADENOSINECHEMBL477Adenosine receptor agonistAGONISTChEMBL
AMINOPHYLLINECHEMBL1370561Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINECHEMBL113Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINE CITRATECHEMBL1200569Adenosine receptor antagonistANTAGONISTChEMBL
NAMODENOSONCHEMBL431733Adenosine A3 receptor agonistAGONISTChEMBL
OXTRIPHYLLINECHEMBL1200434Adenosine receptor antagonistANTAGONISTChEMBL
PICLIDENOSONCHEMBL3989873Adenosine A3 receptor agonistAGONISTChEMBL
QAF805CHEMBL3545204Adenosine A3 receptor antagonistANTAGONISTChEMBL
THEOPHYLLINECHEMBL1355736Adenosine receptor antagonistANTAGONISTChEMBL
THEOPHYLLINE ANHYDROUSCHEMBL190Adenosine receptor antagonistANTAGONISTChEMBL

1 to 10 of 12

See all 12 drugs

Trials172

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07469852CAFFEINEPHASE1/PHASE2ClinicalTrials.gov
NCT07466732CAFFEINEEARLY_PHASE1ClinicalTrials.gov
NCT07456670CAFFEINEPHASE2ClinicalTrials.gov
NCT07410455PICLIDENOSONPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07262060CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07216365CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07086560ADENOSINEClinicalTrials.gov
NCT06972849CAFFEINE CITRATEClinicalTrials.gov
NCT06972108CAFFEINE CITRATEPHASE2ClinicalTrials.gov

1 to 10 of 172

See all 172 trials

NIH grants933

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADORA3 papersNewest fiscal year
ZIADK031117Development of Drugs Acting at Adenosine Receptors1322025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors372025
ZIADK031115Functionalized Congeners of Bioactive Compounds272025
ZIADK031116Development of P2Y Receptor Ligands132025
P30DK056338Texas Medical Center Digestive Diseases Center32025
P30EY001583P30 Core Grant For Vision Research32025
R01HL155950Targeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress Syndrome32025
R35GM128840Discovering and Exploiting Selectivity within Tandem Bromodomains32025
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury32025
ZIADK031127Development of Drugs Acting at Ion Channels32025

1 to 10 of 933Source NIH's project files

See all 933 nih grants

Papers1,628

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cannabinoids as context-dependent modulators of the adenosine A3 receptors: Potential orthosteric and allosteric mechanisms.Pharmacol Res202642785538PubTator, text miningPubMed
Increased ADORA1 expression in pancreatic islets coincides with insulin secretory defects in human type 2 diabetes.J Biol Chem202642660457PubTator, text miningPubMed
Correction: Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury.J Neuroinflammation202642608691PubTator, text miningPubMed
4'-Thionucleosides as adenosine A3 receptor ligands: a medicinal chemistry perspective.Med Chem Res202642446536PubTator, text miningPubMed
From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of A1 and A3 adenosine receptors.Med Chem Res202642446533PubTator, text miningPubMed
Neuropathic pain in traumatic brain injury: consequences, mechanisms, and therapeutic avenues.Inflammopharmacology202642406251PubTator, text miningPubMed
A3 Adenosine Receptor Agonists as Multisystem Disease Modifiers: From Molecular Signaling to Clinical Translation.Biomolecules202642352373PubTator, text miningPubMed
Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.Sci Rep202642265358PubTator, text miningPubMed
Expression of adenosine A1, A2A, A2B, and A3 receptors in ovarian cancer: their clinical potential in diagnosis and prognosis.Mol Biol Rep202642234312PubTator, text miningPubMed
Adenosine receptors in blood cells: Biomarkers and beyond.Pharmacol Res202642219091PubTator, text miningPubMed

1 to 10 of 1,628

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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