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Gene · 1583

CYP11A1: cytochrome P450 family 11 subfamily A member 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. CYP11A1: cytochrome P450 family 11 subfamily A member 1. Genes, record 1583. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1583

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
CYP11A1
HGNC
Name
cytochrome P450 family 11 subfamily A member 1
HGNC
NCBI Gene ID
1583
NCBI Gene
HGNC ID
HGNC:2590
HGNC
Ensembl
ENSG00000140459
NCBI Gene
Aliases
CYP11A, CYPXIA1, P450SCC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05108Cholesterol side-chain cleavage enzyme, mitochondrial5214Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082924 A2026-05-194P05108Espacenet
US 12545918 B22026-02-106P05108Espacenet
EP 4641201 A22025-10-292221P05108Espacenet
JP 2025517969 A2025-06-122221P05108Espacenet
JP 2023515302 A2023-04-135P05108Espacenet
US 11612619 B22023-03-286P05108Espacenet
KR 1020220169238 A2022-12-272P05108Espacenet
US 11446398 B22022-09-2021889P05108Espacenet
JP 2022524081 A2022-04-27124860P05108Espacenet
JP 2021175409 A2021-11-0463P05108Espacenet

1 to 10 of 16

See all 16 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOGLUTETHIMIDECHEMBL488Cytochrome P450 11A1 inhibitorINHIBITORChEMBL
LEVOKETOCONAZOLECHEMBL295698Cytochrome P450 11A1 inhibitorINHIBITORChEMBL
MITOTANECHEMBL1670Cytochrome P450 11A1 inhibitorINHIBITORChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06831175MITOTANEPHASE2ClinicalTrials.gov
NCT05913427MITOTANEPHASE2ClinicalTrials.gov
NCT05634577MITOTANEPHASE22025-06-19ClinicalTrials.gov
NCT05344027MITOTANEClinicalTrials.gov
NCT03723941MITOTANEPHASE3ClinicalTrials.gov
NCT03621280LEVOKETOCONAZOLEPHASE32025-06-19ClinicalTrials.gov
NCT03583710MITOTANEPHASE3ClinicalTrials.gov
NCT03277690LEVOKETOCONAZOLEPHASE32022-11-08ClinicalTrials.gov
NCT02057237MITOTANEPHASE12015-12-17ClinicalTrials.gov
NCT01838551LEVOKETOCONAZOLEPHASE32021-04-19ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

NIH grants1,708

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin412025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer332025
R01DK043140Mechanisms Leading to Adrenal Zonation262025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5162025
P50CA097186The Pacific Northwest Prostate Cancer SPORE132025
ZIAES101586Nuclear receptors: action, functions, and roles in disease132025
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology122025
P30ES013508Center of Excellence in Environmental Toxicology112025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer72025
P30CA013148Comprehensive Cancer Center Support Grant72025

1 to 10 of 1,708Source NIH's project files

See all 1,708 nih grants

Papers4,318

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42813264PubTator, text miningPubMed
42794732PubTator, text miningPubMed
42792964PubTator, text miningPubMed
42777289PubTator, text miningPubMed
42772605PubTator, text miningPubMed
42737821PubTator, text miningPubMed
42737662PubTator, text miningPubMed
42721119PubTator, text miningPubMed
42710202PubTator, text miningPubMed
42644839PubTator, text miningPubMed

1 to 10 of 4,318

See all 4,318 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1583

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