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Gene · 1584

CYP11B1: cytochrome P450 family 11 subfamily B member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP11B1: cytochrome P450 family 11 subfamily B member 1. Genes, record 1584. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1584

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Gene

Symbol
CYP11B1
HGNC
Name
cytochrome P450 family 11 subfamily B member 1
HGNC
NCBI Gene ID
1584
NCBI Gene
HGNC ID
HGNC:2591
HGNC
Ensembl
ENSG00000160882
NCBI Gene
Aliases
CPN1, CYP11B, FHI, P450C11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15538Cytochrome P450 11B1, mitochondrial5032Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442838P15538Espacenet
EP 4641201 A22025-10-293084P15538Espacenet
JP 2025517969 A2025-06-123084P15538Espacenet
US 11446398 B22022-09-2021896P15538Espacenet
JP 2022524081 A2022-04-27124867P15538Espacenet
US 11078247 B22021-08-032798P15538Espacenet
JP 2019054813 A2019-04-11223273P15538Espacenet
JP 2017121241 A2017-07-13223273P15538Espacenet
WO 2016164476 A22016-10-132P15538Espacenet
WO 2015111155 A2015-07-3068P15538Espacenet

1 to 10 of 17

See all 17 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LEVOKETOCONAZOLECHEMBL295698Cytochrome P450 11B1 inhibitorINHIBITORChEMBL
METYRAPONECHEMBL934Cytochrome P450 11B1, mitochondrial inhibitorINHIBITORChEMBL
MITOTANECHEMBL1670Cytochrome P450 11B1 inhibitorINHIBITORChEMBL
OSILODROSTATCHEMBL3099695Cytochrome P450 11B1 inhibitorINHIBITORChEMBL
OSILODROSTAT PHOSPHATECHEMBL3707393Cytochrome P450 11B1 inhibitorINHIBITORChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants869

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP11B1 papersNewest fiscal year
R01DK043140Mechanisms Leading to Adrenal Zonation322025
U54GM115428Mississippi Center for Clinical and Translational Research202025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b5192025
R01DK062027Mechanisms of Adrenal Differentiation82025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P50CA097186The Pacific Northwest Prostate Cancer SPORE52025
R35GM133375Structural regulation of Class-I and Class-II cytochrome P450 enzymes42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 869Source NIH's project files

See all 869 nih grants

Papers2,770

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension.Life (Basel)202642795360PubTator, text miningPubMed
Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells.Biochem Biophys Res Commun202642777615PubTator, text miningPubMed
18F-CETO in adrenocortical carcinoma: first clinical-translational study of an adrenocortical-targeting PET tracer.Endocr Relat Cancer202642775908PubTator, text miningPubMed
Persistent Müllerian structures in an infant with complete androgen insensitivity syndrome.JCEM Case Rep202642756908PubTator, text miningPubMed
[Clinical analysis of two cases of 11β-hydroxylase deficiency diagnosed after adrenal mass resection].Zhonghua Nei Ke Za Zhi202642733267PubTator, text miningPubMed
Incidental discovery of neglected 11β-hydroxylase deficiency causing 46,XX disorder of sex development in a 35-year-old adult: A radiologically driven diagnosis.Radiol Case Rep202642707067PubTator, text miningPubMed
APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial.JCO Precis Oncol202642628007PubTator, text miningPubMed
Bilateral adrenal adenomas presenting with ACTH-independent Cushing's syndrome and primary aldosteronism: diagnostic insights from multi-steroid adrenal venous sampling.Front Endocrinol (Lausanne)202642609288PubTator, text miningPubMed
[A follow-up study of 10 Uyghur children with 11β-hydroxylase deficiency in the Xinjiang region].Zhongguo Dang Dai Er Ke Za Zhi202642608305PubTator, text miningPubMed
Clinical and genetic characteristics of patients with complete androgen insensitivity syndrome: an experience from a tertiary care centre of Kashmir Valley.Endocrine202642545618PubTator, text miningPubMed

1 to 10 of 2,770

See all 2,770 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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