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Gene · 1859

DYRK1A: dual specificity tyrosine phosphorylation regulated kinase 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DYRK1A: dual specificity tyrosine phosphorylation regulated kinase 1A. Genes, record 1859. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1859

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Gene

Symbol
DYRK1A
HGNC
Name
dual specificity tyrosine phosphorylation regulated kinase 1A
HGNC
NCBI Gene ID
1859
NCBI Gene
HGNC ID
HGNC:3091
HGNC
Ensembl
ENSG00000157540
NCBI Gene
Aliases
DYRK, DYRK1, HP86, MNB, MNBH, MRD7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13627Dual specificity tyrosine-phosphorylation-regulated kinase 1A76392Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4727938 A12026-04-221Q13627Espacenet
JP 2026004568 A2026-01-1444351Q13627Espacenet
EP 4641201 A22025-10-296280Q13627Espacenet
JP 2025517969 A2025-06-126280Q13627Espacenet
WO 2024259116 A12024-12-191Q13627Espacenet
WO 2024259121 A12024-12-191Q13627Espacenet
US 11976334 B22024-05-07136Q13627Espacenet
US 11446398 B22022-09-2025833Q13627Espacenet
JP 2022524081 A2022-04-27128804Q13627Espacenet
US 11078247 B22021-08-033343Q13627Espacenet

1 to 10 of 36

See all 36 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LORECIVIVINTCHEMBL4297639Dual specificity tyrosine-phosphorylation-regulated kinase 1A inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05603754LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04931667LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04520607LORECIVIVINTPHASE3ClinicalTrials.gov
NCT04385303LORECIVIVINTPHASE32026-02-04ClinicalTrials.gov
NCT03928184LORECIVIVINTPHASE32026-02-13ClinicalTrials.gov
NCT03727022LORECIVIVINTPHASE22026-01-12ClinicalTrials.gov
NCT03706521LORECIVIVINTPHASE22026-03-04ClinicalTrials.gov
NCT03246399LORECIVIVINTPHASE1ClinicalTrials.gov
NCT03122860LORECIVIVINTPHASE22021-05-18ClinicalTrials.gov
NCT02536833LORECIVIVINTPHASE22020-09-16ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants2,474

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDYRK1A papersNewest fiscal year
R01MH101221Rare Mutations and Autism Spectrum Disorders322025
P30CA016672Cancer Center Support Grant152025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)152025
P30CA008748Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)72025
P30DK020593Vanderbilt Diabetes Research Center72025
T32HG000035Interdisciplinary Training in Genome Sciences62025
P30CA014051Cancer Center Support (Core) Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA068485Cancer Center Support Grant52025

1 to 10 of 2,474Source NIH's project files

See all 2,474 nih grants

Papers3,825

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic architecture and molecular pathogenesis of Parkinson's disease: emerging mechanisms and therapeutic targets.Metab Brain Dis202642803978PubTator, text miningPubMed
Targeting DYRK1A with rationally designed pyrazine-guanidine hybrids for Alzheimer's disease: design, synthesis, and biological evaluation.RSC Adv202642780659PubTator, text miningPubMed
Harmine selectively enhances human beta cell identity markers and function via protein kinase A pathways.Diabetologia202642766004PubTator, text miningPubMed
Network modeling predicts how DYRK1A inhibition promotes cardiomyocyte cycling after ischemia/reperfusion injury.JCI Insight202642752366PubTator, text miningPubMed
DYRK kinases phosphorylate IL-17RA at S801.Serican J Med202642746556PubTator, text miningPubMed
Baseline cellular state shapes the molecular impact of mutant Kirsten rat sarcoma viral oncogene homologue (KRAS) alleles in reconstituted pancreatic cancer cells.Mol Omics202642720273PubTator, text miningPubMed
Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome.Med Res Arch202642677302PubTator, text miningPubMed
In silico structure-based design of superior DYRK1A enzyme inhibitors.Comput Biol Chem202642673670PubTator, text miningPubMed
Small-molecule DYRK1A Inhibitors for β-Cell Regeneration in Diabetes: Structural Insights and Medicinal Chemistry Advances.Mini Rev Med Chem202642634309PubTator, text miningPubMed
Design, synthesis and biological evaluation of quinazoline-carbazole derivatives as dual TXNIP/DYRK1A inhibitors for the treatment of type 2 diabetes mellitus.Mol Divers202642631845PubTator, text miningPubMed

1 to 10 of 3,825

See all 3,825 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/1859/patents?page=2