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Gene · 187

APLNR: apelin receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APLNR: apelin receptor. Genes, record 187. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/187

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Gene

Symbol
APLNR
HGNC
Name
apelin receptor
HGNC
NCBI Gene ID
187
NCBI Gene
HGNC ID
HGNC:339
HGNC
Ensembl
ENSG00000134817
NCBI Gene
Aliases
AGTRL1, APJ, APJR, FLJ90771, HG11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35414Apelin receptor38039Ensembl, GeneID, HGNC

Source UniProt

Patents119

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-291231P35414Espacenet
JP 2025529142 A2025-09-04412P35414Espacenet
EP 4606428 A22025-08-2718P35414Espacenet
US 12371689 B22025-07-29412P35414Espacenet
JP 2025517969 A2025-06-121231P35414Espacenet
EP 4541896 A12025-04-23270P35414Espacenet
JP 2025062604 A2025-04-145606P35414Espacenet
JP 2025062604 A2025-04-145607P35414Espacenet
JP 2025062604 A2025-04-145608P35414Espacenet
JP 2025032204 A2025-03-1124562P35414Espacenet

1 to 10 of 119

See all 119 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
APELINCHEMBL4650373Apelin receptor agonistAGONIST

Source ChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPLNR papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P51OD011106Wisconsin National Primate Research Center Support52025
P30CA006516Dana-Farber/Harvard Cancer Center32025
P30CA016672Cancer Center Support Grant32025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides32025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology22025
P30AI064518Center for AIDS Research22025
P30DK116074Stanford Diabetes Research Center22025
P30EY003039UAB Core Grant for Vision Research22025
P51OD011104Tulane National Primate Research Center22025

1 to 10 of 941Source NIH's project files

See all 941 nih grants

Papers2,018

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Agonist Binding Reshapes the Kinetic Landscape and Allosteric Communication of APLNR Toward Activation-Competent States.Int J Mol Sci202642737571PubTator, text miningPubMed
A 3D in vitro co-culture model to investigate tumor-endothelial interactions in Neurofibromatosis type 2-associated meningiomas.Neurooncol Adv202642730193PubTator, text miningPubMed
The Role of High Serum Apelin Levels Within the First 24 h in Predicting 28-Day and Long-Term Mortality in Ischemic Cerebrovascular Disease.J Clin Med202642652872PubTator, text miningPubMed
The apelin/APJ signaling axis in ocular neurovascular disorders: Molecular mechanisms and therapeutic strategies for angiogenesis and neurodegeneration.Biomed Pharmacother202642623845PubTator, text miningPubMed
A Novel Ocular Fibrosis Signature for AMD Using the Two-Stage Laser-Induced Subretinal Fibrosis Mouse Model.Invest Ophthalmol Vis Sci202642615798PubTator, text miningPubMed
Structure-based design of non-hypertrophic apelin receptor modulator.Cell202642561932PubTator, text miningPubMed
The Apelin-APJ Axis in Heart Failure: Mechanistic Insights, Clinical Evidence, and Translational Challenges.Cardiovasc Drugs Ther202642455245PubTator, text miningPubMed
Apelin, Cortisol, and Doxorubicin-Induced Cardiotoxicity: A Triangle of Actions.Cells202642439664PubTator, text miningPubMed
The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling.Br J Pharmacol202642399569PubTator, text miningPubMed
Apelin-APLNR pathway across development, inflammation, and vascular remodeling: an endothelial perspective.Exp Mol Med202642393311PubTator, text miningPubMed

1 to 10 of 2,018

See all 2,018 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/187

GET https://conductscience.org/api/genes/v1/187/patents?page=2