Gene · 187
APLNR: apelin receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. APLNR: apelin receptor. Genes, record 187. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/187
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35414 | Apelin receptor | 380 | 39 | Ensembl, GeneID, HGNC |
Source UniProt
Patents119
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 1231 | P35414 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 412 | P35414 | Espacenet |
| EP 4606428 A2 | 2025-08-27 | 18 | P35414 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 412 | P35414 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1231 | P35414 | Espacenet |
| EP 4541896 A1 | 2025-04-23 | 270 | P35414 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5606 | P35414 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5607 | P35414 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5608 | P35414 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24562 | P35414 | Espacenet |
1 to 10 of 119
See all 119 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| APELIN | CHEMBL4650373 | Apelin receptor agonist | AGONIST |
Source ChEMBL
Trials8
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06277336 | APELIN | ClinicalTrials.gov | ||
| NCT03449251 | APELIN | PHASE2 | ClinicalTrials.gov | |
| NCT02724566 | APELIN | PHASE1 | ClinicalTrials.gov | |
| NCT01457170 | APELIN | ClinicalTrials.gov | ||
| NCT01179061 | APELIN | ClinicalTrials.gov | ||
| NCT01049646 | APELIN | ClinicalTrials.gov | ||
| NCT00901888 | APELIN | ClinicalTrials.gov | ||
| NCT00901719 | APELIN | ClinicalTrials.gov |
NIH grants941
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | APLNR papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P51OD011106 | Wisconsin National Primate Research Center Support | 5 | 2025 |
| P30CA006516 | Dana-Farber/Harvard Cancer Center | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01DA008863 | Regulation Of Opioid Receptor Signaling by Endogenous Peptides | 3 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 2 | 2025 |
| P30AI064518 | Center for AIDS Research | 2 | 2025 |
| P30DK116074 | Stanford Diabetes Research Center | 2 | 2025 |
| P30EY003039 | UAB Core Grant for Vision Research | 2 | 2025 |
| P51OD011104 | Tulane National Primate Research Center | 2 | 2025 |
1 to 10 of 941Source NIH's project files
See all 941 nih grantsPapers2,018
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Agonist Binding Reshapes the Kinetic Landscape and Allosteric Communication of APLNR Toward Activation-Competent States. | Int J Mol Sci | 2026 | 42737571 | PubTator, text mining | PubMed |
| A 3D in vitro co-culture model to investigate tumor-endothelial interactions in Neurofibromatosis type 2-associated meningiomas. | Neurooncol Adv | 2026 | 42730193 | PubTator, text mining | PubMed |
| The Role of High Serum Apelin Levels Within the First 24 h in Predicting 28-Day and Long-Term Mortality in Ischemic Cerebrovascular Disease. | J Clin Med | 2026 | 42652872 | PubTator, text mining | PubMed |
| The apelin/APJ signaling axis in ocular neurovascular disorders: Molecular mechanisms and therapeutic strategies for angiogenesis and neurodegeneration. | Biomed Pharmacother | 2026 | 42623845 | PubTator, text mining | PubMed |
| A Novel Ocular Fibrosis Signature for AMD Using the Two-Stage Laser-Induced Subretinal Fibrosis Mouse Model. | Invest Ophthalmol Vis Sci | 2026 | 42615798 | PubTator, text mining | PubMed |
| Structure-based design of non-hypertrophic apelin receptor modulator. | Cell | 2026 | 42561932 | PubTator, text mining | PubMed |
| The Apelin-APJ Axis in Heart Failure: Mechanistic Insights, Clinical Evidence, and Translational Challenges. | Cardiovasc Drugs Ther | 2026 | 42455245 | PubTator, text mining | PubMed |
| Apelin, Cortisol, and Doxorubicin-Induced Cardiotoxicity: A Triangle of Actions. | Cells | 2026 | 42439664 | PubTator, text mining | PubMed |
| The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling. | Br J Pharmacol | 2026 | 42399569 | PubTator, text mining | PubMed |
| Apelin-APLNR pathway across development, inflammation, and vascular remodeling: an endothelial perspective. | Exp Mol Med | 2026 | 42393311 | PubTator, text mining | PubMed |
1 to 10 of 2,018
See all 2,018 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/187
GET https://conductscience.org/api/genes/v1/187/patents?page=2