Gene · 2053
EPHX2: epoxide hydrolase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EPHX2: epoxide hydrolase 2. Genes, record 2053. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2053
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P34913 | Bifunctional epoxide hydrolase 2 | 555 | 141 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45144 | P34913 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 18273 | P34913 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 18273 | P34913 | Espacenet |
| US 11690837 B2 | 2023-07-04 | 40 | P34913 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 27819 | P34913 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 130790 | P34913 | Espacenet |
| US 11123311 B2 | 2021-09-21 | 1 | P34913 | Espacenet |
| US 11047010 B2 | 2021-06-29 | 2244 | P34913 | Espacenet |
| US 10865447 B2 | 2020-12-15 | 2244 | P34913 | Espacenet |
| US 10369141 B2 | 2019-08-06 | 40 | P34913 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03486223 | GSK2256294 | PHASE2 | 2023-03-23 | ClinicalTrials.gov |
| NCT03318783 | GSK2256294 | PHASE1/PHASE2 | 2021-01-22 | ClinicalTrials.gov |
| NCT00847899 | AR9281 | PHASE2 | ClinicalTrials.gov |
NIH grants1,549
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EPHX2 papers | Newest fiscal year |
|---|---|---|---|
| R35ES030443 | Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases | 102 | 2025 |
| ZIAES025034 | Characterization And Functional Significance Of P450 Arachidonate Epoxygenases | 38 | 2025 |
| T32ES007059 | Advanced Training in Environmental Health Sciences | 25 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 14 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 10 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 9 | 2025 |
| U54NS127758 | UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication | 9 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 5 | 2025 |
1 to 10 of 1,549Source NIH's project files
See all 1,549 nih grantsPapers2,484
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Distinct lipid mediator profiles in brain and liver tissues in Alzheimer's disease. | medRxiv | 2026 | 42818430 | PubTator, text mining | PubMed |
| Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma. | J Environ Sci Health B | 2026 | 42811799 | PubTator, text mining | PubMed |
| Soluble epoxide hydrolase research, international collaboration, and translational capacity in Brazil: the scientific legacy of Bruce D. Hammock. | Drug Metab Dispos | 2026 | 42805148 | PubTator, text mining | PubMed |
| Anti-Inflammatory Activity of Monoterpene Phenol Dimers from Satureja bachtiarica. | ACS Omega | 2026 | 42799005 | PubTator, text mining | PubMed |
| EPHX2 Loss Promotes CRC Migration via EET-Dependent Chemokine Elevation and Mitochondrial Defect. | Cancer Sci | 2026 | 42732782 | PubTator, text mining | PubMed |
| Altered Epoxyeicosatrienoic Acid Signaling in Advanced-Stage Alzheimer's Disease (Investigation of Epoxyeicosatrienoic Acid Levels in Patients with Advanced Alzheimer's Disease). | Curr Alzheimer Res | 2026 | 42725525 | PubTator, text mining | PubMed |
| The Roles of EETs in Neurological Disorders. | CNS Neurosci Ther | 2026 | 42711888 | PubTator, text mining | PubMed |
| Design, synthesis, and biological evaluation of novel pyrimidine-sulfonamide derivatives as multi-targeted COX-2/5-LOX/sEH inhibitors with potential antiproliferative properties. | RSC Adv | 2026 | 42662511 | PubTator, text mining | PubMed |
| EPHX2 Expression and Its Association with Prognosis, Metabolic Regulation, and Metastasis-Related Pathways in Lung Adenocarcinoma. | Genes (Basel) | 2026 | 42650154 | PubTator, text mining | PubMed |
Retraction notice to "Reducing degradation of EETs by sEH protein macromolecule depletion prevents MCAO and inhibits microglia-mediated inflammatory response" [Int. J. Biol. Macromol. 317 (2025) 144820]. | Int J Biol Macromol | 2026 | 42613210 | PubTator, text mining | PubMed |
1 to 10 of 2,484
See all 2,484 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2053
GET https://conductscience.org/api/genes/v1/2053/patents?page=2