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Gene · 2166

FAAH: fatty acid amide hydrolase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FAAH: fatty acid amide hydrolase. Genes, record 2166. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2166

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Gene

Symbol
FAAH
HGNC
Name
fatty acid amide hydrolase
HGNC
NCBI Gene ID
2166
NCBI Gene
HGNC ID
HGNC:3553
HGNC
Ensembl
ENSG00000117480
NCBI Gene
Aliases
FAAH-1, FAAH1, PSAB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00519Fatty-acid amide hydrolase 15790Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445922O00519Espacenet
JP 2025536211 A2025-11-053O00519Espacenet
JP 2025535021 A2025-10-225O00519Espacenet
JP 2025529142 A2025-09-041471O00519Espacenet
US 12371689 B22025-07-291471O00519Espacenet
US 12241066 B22025-03-0440O00519Espacenet
US 11446398 B22022-09-2030851O00519Espacenet
US 11400116 B22022-08-022375O00519Espacenet
JP 2022524081 A2022-04-27133822O00519Espacenet
JP 2021512929 A2021-05-2040O00519Espacenet

1 to 10 of 34

See all 34 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETAMINOPHENCHEMBL112Anandamide amidohydrolase inhibitorINHIBITORChEMBL
JNJ-42165279CHEMBL4297294Anandamide amidohydrolase inhibitorINHIBITORChEMBL
REDAFAMDASTATCHEMBL1651534Anandamide amidohydrolase inhibitorINHIBITORChEMBL

Trials299

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,032

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFAAH papersNewest fiscal year
P01DA009158Endocannabinoid Active Sites as Therapeutic Targets282025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology132025
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury122025
ZIAAA000301Integrative genetics of behavior with high throughput technologies92025
R37DA015648Modulating Signaling Endocannabinoids and Fatty Acid Amides82025
T32DA007027Training in the pharmacology of abused drugs82025
UL1TR001863Yale Clinical and Translational Science Award82025
ZIAAA000411Mouse models of stress disorders and addiction82025
ZIAAA000351Endocannabinoids and the Control Of Behavior and Cardiovascular Function72025
R35ES030443Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases62025

1 to 10 of 2,032Source NIH's project files

See all 2,032 nih grants

Papers3,784

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural optimization of donepezil-like hybrids toward an improved multi-target and ADME-related profile.Bioorg Chem202642826663PubTator, text miningPubMed
Tryptamide (nicotredole) revisited: re-examining a forgotten anti-inflammatory agent by large-scale target profiling and ADMET studies.Pharmacol Rep202642811266PubTator, text miningPubMed
In Vivo Characterization of Fatty Acid Amide Hydrolase in Posttraumatic Stress Disorder: A [11C]CURB Positron Emission Tomography Study.Biol Psychiatry202642772587PubTator, text miningPubMed
Tai Chi exercise of short duration alters circulating oxylipins in postmenopausal women: a pilot study.Front Med (Lausanne)202642740961PubTator, text miningPubMed
N-Arachidonoyl-phosphatidylethanolamide phospholipase D activation by muscarinic receptors.J Physiol202642687141PubTator, text miningPubMed
Fatty acid amide hydrolase (FAAH) inhibitor design and preclinical studies: lessons learned from BIA 10-2474 and the challenges ahead.Expert Opin Drug Discov202642615850PubTator, text miningPubMed
Mechanistic Insights into the Analgesic Action of Acetaminophen: Its Bioactive Metabolite Induces Peripheral Analgesia in Addition to Central Analgesia.Med Princ Pract202642607026PubTator, text miningPubMed
Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review.Front Psychiatry202642602360PubTator, text miningPubMed
Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha-Fatty-Acid Amide Hydrolase 1 Signaling Pathway.MedComm (2020)202642558980PubTator, text miningPubMed
Quantification of [11C]CURB PET using an irreversible reference tissue model with a cluster-derived pseudo-reference region.Front Neurosci202642548758PubTator, text miningPubMed

1 to 10 of 3,784

See all 3,784 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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