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Gene · 2222

FDFT1: farnesyl-diphosphate farnesyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FDFT1: farnesyl-diphosphate farnesyltransferase 1. Genes, record 2222. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2222

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Gene

Symbol
FDFT1
HGNC
Name
farnesyl-diphosphate farnesyltransferase 1
HGNC
NCBI Gene ID
2222
NCBI Gene
HGNC ID
HGNC:3629
HGNC
Ensembl
ENSG00000079459
NCBI Gene
Aliases
DGPT, ERG9, SQS, SQSD, SS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P37268Squalene synthase41732Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4726050 A22026-04-15200P37268Espacenet
JP 2026004568 A2026-01-1445864P37268Espacenet
EP 4650780 A22025-11-19475P37268Espacenet
EP 4641202 A22025-10-2917P37268Espacenet
US 12416034 B22025-09-16200P37268Espacenet
JP 2025529142 A2025-09-041564P37268Espacenet
US 12371689 B22025-07-291564P37268Espacenet
JP 2025517970 A2025-06-12475P37268Espacenet
JP 2025032204 A2025-03-1128330P37268Espacenet
JP 2025032204 A2025-03-1128344P37268Espacenet

1 to 10 of 64

See all 64 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LAPAQUISTAT ACETATECHEMBL435224Squalene synthetase inhibitorINHIBITOR

Source ChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00868127LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00865228LAPAQUISTAT ACETATEPHASE2ClinicalTrials.gov
NCT00864643LAPAQUISTAT ACETATEPHASE2ClinicalTrials.gov
NCT00813527LAPAQUISTAT ACETATEPHASE2ClinicalTrials.gov
NCT00532558LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00532311LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00286481LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00268697LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00263081LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov
NCT00256178LAPAQUISTAT ACETATEPHASE3ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants1,363

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFDFT1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30DK063491Diabetes Research Center (DRC)52025
P50AA011999Southern California Research Center for ALPD and Cirrhosis52025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA023168Cancer Center Support Grant32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
P30DK026743UCSF Liver Center32025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease32025
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma22025
P30CA016056Roswell Park Cancer Center Support Grant22025

1 to 10 of 1,363Source NIH's project files

See all 1,363 nih grants

Papers2,006

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
FDFT1 is associated with ovarian reserve and regulates proliferation and steroidogenesis in the human granulosa cell line KGN via the AKT/mTOR signaling pathway.J Steroid Biochem Mol Biol202742705556PubTator, text miningPubMed
Combined Analysis of Metabolome and Transcriptome Reveals Bauhinia variegata-Specific Floral Scent Profile and Key Aroma Components.Metabolites202642783736PubTator, text miningPubMed
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.Drug Dev Res202642750477PubTator, text miningPubMed
GhSQS1-mediated squalene accumulation coordinates cotton development and stress resilience.J Exp Bot202642717800PubTator, text miningPubMed
Postzygotic biallelic inactivation of FDFT1 underlies solitary lesion formation in porokeratosis of Mibelli.J Dermatol Sci202642716848PubTator, text miningPubMed
Brusatol Triggers Cell Cycle Arrest and Apoptosis, Disrupts Sterol Biosynthesis, and Enhances the Anti-Leukemic Activity of Venetoclax in AML Cells.Cell Biochem Biophys202642711651PubTator, text miningPubMed
Enantioselective Total Synthesis of (+)-Bisabosqual A and Studies on Late-Stage C(sp3)-H Functionalization Approaches to Bisabosquals.J Org Chem202642681704PubTator, text miningPubMed
Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Front Genet202642626419PubTator, text miningPubMed
Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis.Mol Med Rep202642596822PubTator, text miningPubMed
Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis.Front Immunol202642488674PubTator, text miningPubMed

1 to 10 of 2,006

See all 2,006 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2222

GET https://conductscience.org/api/genes/v1/2222/patents?page=2