Gene · 2222
FDFT1: farnesyl-diphosphate farnesyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FDFT1: farnesyl-diphosphate farnesyltransferase 1. Genes, record 2222. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2222
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P37268 | Squalene synthase | 417 | 32 | Ensembl, GeneID, HGNC |
Source UniProt
Patents64
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4726050 A2 | 2026-04-15 | 200 | P37268 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 45864 | P37268 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 475 | P37268 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 17 | P37268 | Espacenet |
| US 12416034 B2 | 2025-09-16 | 200 | P37268 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1564 | P37268 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1564 | P37268 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 475 | P37268 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28330 | P37268 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28344 | P37268 | Espacenet |
1 to 10 of 64
See all 64 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LAPAQUISTAT ACETATE | CHEMBL435224 | Squalene synthetase inhibitor | INHIBITOR |
Source ChEMBL
Trials14
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT00868127 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00865228 | LAPAQUISTAT ACETATE | PHASE2 | ClinicalTrials.gov | |
| NCT00864643 | LAPAQUISTAT ACETATE | PHASE2 | ClinicalTrials.gov | |
| NCT00813527 | LAPAQUISTAT ACETATE | PHASE2 | ClinicalTrials.gov | |
| NCT00532558 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00532311 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00286481 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00268697 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00263081 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov | |
| NCT00256178 | LAPAQUISTAT ACETATE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 14
See all 14 trialsNIH grants1,363
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FDFT1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 3 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 3 | 2025 |
| P30DK026743 | UCSF Liver Center | 3 | 2025 |
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 3 | 2025 |
| P01CA117969 | Genetics and Biology of Pancreatic Ductal Adenocarcinoma | 2 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,363Source NIH's project files
See all 1,363 nih grantsPapers2,006
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| FDFT1 is associated with ovarian reserve and regulates proliferation and steroidogenesis in the human granulosa cell line KGN via the AKT/mTOR signaling pathway. | J Steroid Biochem Mol Biol | 2027 | 42705556 | PubTator, text mining | PubMed |
| Combined Analysis of Metabolome and Transcriptome Reveals Bauhinia variegata-Specific Floral Scent Profile and Key Aroma Components. | Metabolites | 2026 | 42783736 | PubTator, text mining | PubMed |
| Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis. | Drug Dev Res | 2026 | 42750477 | PubTator, text mining | PubMed |
| GhSQS1-mediated squalene accumulation coordinates cotton development and stress resilience. | J Exp Bot | 2026 | 42717800 | PubTator, text mining | PubMed |
| Postzygotic biallelic inactivation of FDFT1 underlies solitary lesion formation in porokeratosis of Mibelli. | J Dermatol Sci | 2026 | 42716848 | PubTator, text mining | PubMed |
| Brusatol Triggers Cell Cycle Arrest and Apoptosis, Disrupts Sterol Biosynthesis, and Enhances the Anti-Leukemic Activity of Venetoclax in AML Cells. | Cell Biochem Biophys | 2026 | 42711651 | PubTator, text mining | PubMed |
| Enantioselective Total Synthesis of (+)-Bisabosqual A and Studies on Late-Stage C(sp3)-H Functionalization Approaches to Bisabosquals. | J Org Chem | 2026 | 42681704 | PubTator, text mining | PubMed |
| Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study. | Front Genet | 2026 | 42626419 | PubTator, text mining | PubMed |
| Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis. | Mol Med Rep | 2026 | 42596822 | PubTator, text mining | PubMed |
| Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis. | Front Immunol | 2026 | 42488674 | PubTator, text mining | PubMed |
1 to 10 of 2,006
See all 2,006 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2222
GET https://conductscience.org/api/genes/v1/2222/patents?page=2